{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:23:15Z","timestamp":1790029395058,"version":"4.0.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Incidence of traumatic brain injury (TBI) is rising in older adults. Dementia is a common comorbidity and may worsen post-TBI outcomes, but its effects have not been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare all-cause mortality following TBI or non-TBI trauma (NTT) and quantify the impacts of age, deprivation and dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Population-based retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Linked primary and secondary care electronic health records from the Secure Anonymised Information Linkage Databank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>Adult residents in Wales aged 18\u2013100 with hospitalised TBI or NTT recorded between January 2000 and December 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cox proportional hazard models were used to estimate survival within 1, 6 and 12\u00a0months of hospitalised TBI\/NTT in those with and without pre-injury dementia diagnosis. Groups were propensity-matched by age, sex and morbidities. Models were stratified by age, sex and deprivation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 23\u00a0428 TBIs (n\u2009=\u200918\u00a0940) and 589\u00a0169 NTTs (n\u2009=\u2009421\u00a0259) were identified. TBIs were associated with higher mortality than NTT at all timepoints. Older age was associated with higher mortality after TBI, with 16.9% 1-month mortality in patients aged 65\u201379, and 31% in patients aged 80\u2013100. In TBI patients, 30-day mortality was significant irrespective of dementia. About 6- and 12-month mortality were higher in those with than without pre-injury dementia diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TBI is associated with higher all-cause mortality than NTT, particularly in older age. Among those with TBI, patients with pre-injury dementia had particularly high chronic mortality. There is an urgent need to understand the reasons for poor outcomes in older adult TBI populations, especially those with dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afaf341","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T12:57:10Z","timestamp":1763297830000},"source":"Crossref","is-referenced-by-count":5,"title":["Traumatic brain injury and mortality in older adults with and without pre-injury dementia"],"prefix":"10.1093","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-8440","authenticated-orcid":false,"given":"Helen","family":"Lai","sequence":"first","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Soreq","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall J","family":"Bourke","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Centre for Neuroimaging Sciences , King's College London, London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-6087","authenticated-orcid":false,"given":"Claire","family":"Baker","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Dyson School of Design Engineering, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]},{"name":"Department of Bioengineering, Imperial College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J C","family":"Daniels","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W","family":"Gregg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Imperial College London , London ,","place":["UK"]},{"name":"School of Population Health , Royal College of Surgeons, Dublin, Leinster ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sharp","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia M","family":"Li","sequence":"additional","affiliation":[{"name":"Brain Sciences, Imperial College London , London ,","place":["UK"]},{"name":"Care Research and Technology Centre, UK Dementia Research Institute , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"2025120408285377200_ref1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, 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