{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:07:41Z","timestamp":1779912461802,"version":"3.53.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inclusion of older adults in research ensures both equity and relevance. We used National Institute of Health and Care Research Year of Birth data to describe inclusion of older adults in contemporary UK clinical research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We worked with English research networks to collect individual participant level data on recruits into National Institute of Health and Care Research portfolio studies. We used data from 2022\u20132023 to 2023\u20132024 to assess participation. We described data in terms of geography, primary speciality managing the study and study characteristics. In subgroup analyses, we assessed inclusion of the \u2018oldest old\u2019 (aged over 85\u00a0years) and inclusion in research from three exemplars: heart failure, Parkinson\u2019s disease and palliative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 455\u00a0734 participants were included in the analyses. The most common age group included in UK research was 65\u201374\u00a0years (15.5%). People aged over 85\u00a0years were 3.2% of all recruits, and this proportion decreased over time. There was modest geographical variation in participant age but marked variation by recruiting speciality. People aged over 85\u00a0years accounted for less than 5% of the total participants recruited in 9 of 14 specialities assessed. Older adults were less likely to be recruited into commercial studies. For three conditions of interest, recruitment did not match population epidemiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This project has demonstrated feasibility of collecting participant age data at scale and provides important metrics for understanding study participation. While there is scope to improve older adult participation across all the study portfolio, there are major equity issues around inclusion in certain speciality areas and commercial research. To complement this abstract, a video abstract is available online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afag143","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:40:14Z","timestamp":1778067614000},"source":"Crossref","is-referenced-by-count":0,"title":["Inclusion of older adults in UK clinical research\u2014the National Institute for Health and Care Research Year of Birth Project"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9313-3894","authenticated-orcid":false,"given":"Martyn","family":"Patel","sequence":"first","affiliation":[{"name":"Norfolk and Norwich University Hospitals NHS Foundation Trust, Older Peoples Medicine , 7 Colney Lane, Norwich NR4 7UY ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Tiwari","sequence":"additional","affiliation":[{"name":"University Hospitals Dorset NHS Foundation Trust, Poole , Bournemouth, Christchurch ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamaila","family":"Anwar","sequence":"additional","affiliation":[{"name":"NIHR\u2014RDN Coordinating Centre , Leeds ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Evans","sequence":"additional","affiliation":[{"name":"University of Exeter, Medical School (Primary Care) , Exeter ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Meersschaert","sequence":"additional","affiliation":[{"name":"Universite de Poitiers , Faculte de Sciences, Poitiers, Nouvelle-Aquitaine ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-9105","authenticated-orcid":false,"given":"Jatinder S","family":"Minhas","sequence":"additional","affiliation":[{"name":"University of Leicester , Division of Cardiovascular Sciences, Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-7065","authenticated-orcid":false,"given":"Jane A H","family":"Masoli","sequence":"additional","affiliation":[{"name":"University of Exeter, Epidemiology and Public Health, University of Exeter Medical School, College House, University of Exeter Medical School , St Luke's Campus Heavitree Road, Exeter EX4 4QJ ,","place":["UK"]},{"name":"Royal Devon and Exeter NHS Foundation Trust, Healthcare for Older Adults , Barrack Road, Exeter EX2 5DW ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-0181","authenticated-orcid":false,"given":"Terence J","family":"Quinn","sequence":"additional","affiliation":[{"name":"University of Glasgow, Cardiovascular and Medical Sciences, Glasgow Royal Infirmary , Walton Building, Glasgow G4 0SF ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"2026052715433222800_ref1","doi-asserted-by":"publisher","first-page":"e674","DOI":"10.1016\/S2666-7568(22)00186-6","article-title":"Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43\u2008895 trials and 5\u2008685\u2008738 individuals across 989 unique drugs and 286 conditions in England","volume":"3","author":"Tan","year":"2022","journal-title":"Lancet Healthy Longev"},{"key":"2026052715433222800_ref2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12916-020-01555-4","article-title":"Is health research undertaken where the burden of disease is greatest? 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