{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:43:29Z","timestamp":1792673009596,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic subdural haematoma (cSDH) is common in older adults, and medication exposures may influence postoperative outcomes. We assessed whether pre-surgery statin use is associated with short- and long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide registry study of adults undergoing surgical evacuation of traumatic or non-traumatic cSDH (6\/2004\u201312\/2018) in Finnish university hospitals. Pre-surgery statin use was defined from national prescription records using a pill-counting approach. The primary outcome was 30-day all-cause mortality. Secondary outcomes were 30-day reoperation and length of hospital stay. Tertiary outcomes were 1-year mortality and reoperation. Mortality was analysed using Cox regression; reoperation with Fine\u2013Gray models accounting for competing risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort included 9001 patients, of whom 2450 (27.2%) used statins. Thirty-day mortality was 3.3% in statin users and 4.5% in non-users, with lower adjusted mortality among statin users (HR 0.57; 95% CI 0.44\u20130.73). Reoperation within 30\u00a0days (n\u00a0=\u2009897) was similar between groups (sub-distribution HR 1.08; 95% CI 0.97\u20131.21). Hospital stay was shorter in statin users (22.1\u2009\u00b1\u200962.7 vs 26.3\u2009\u00b1\u200977.5\u00a0days; adjusted P\u00a0=\u2009.002). At 1 year, mortality remained lower in statin users (13.3% vs 15.4%; HR 0.66; 95% CI 0.58\u20130.75), with no difference in reoperation (sub-distribution HR 1.09; 95% CI 0.96\u20131.22).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this nationwide cohort of surgically treated cSDH patients, pre-surgery statin use was associated with lower short- and long-term mortality and shorter hospital stay, while reoperation rates were similar between statin users and non-users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ageing\/afag296","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:53:07Z","timestamp":1792669987000},"source":"Crossref","is-referenced-by-count":0,"title":["Pre-surgery statin use and outcomes in operated chronic subdural haematomas: a nationwide cohort study"],"prefix":"10.1093","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-5193","authenticated-orcid":false,"given":"Jussi P","family":"Posti","sequence":"first","affiliation":[{"name":"Neurocenter, Department of Neurosurgery, Turku University Hospital , Turku ,","place":["Finland"]},{"name":"Neurosurgery, Clinical Neurosciences, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksi","family":"Tornio","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Turku , Turku ,","place":["Finland"]},{"name":"Unit of Clinical Pharmacology, Turku University Hospital , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jori O","family":"Ruuskanen","sequence":"additional","affiliation":[{"name":"Neurocenter, Department of Neurology, Turku University Hospital , Turku ,","place":["Finland"]},{"name":"Neurology, Clinical Neurosciences, University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-9591","authenticated-orcid":false,"given":"Rahul","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Luoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tampere University Hospital, Tampere University , Tampere ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-1946","authenticated-orcid":false,"given":"Pihla","family":"Tommiska","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Helsinki University Hospital and University of Helsinki , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-1093","authenticated-orcid":false,"given":"Ville","family":"Kyt\u00f6","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Turku University Hospital , Turku ,","place":["Finland"]},{"name":"Heart Centre, Turku University Hospital and University of Turku , Turku ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"2026102207530142400_ref1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.wneu.2022.07.079","article-title":"The effect of statins on the recurrence of chronic subdural hematomas: a systematic review and meta-analysis","volume":"166","author":"Monteiro","year":"2022","journal-title":"World 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