{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:40:01Z","timestamp":1791988801254,"version":"4.4.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The National Osteoporosis Society (NOS) published its document, Vitamin D and Bone Health: A Practical Clinical Guideline for Patient Management, in 2013 as a practical clinical guideline on the management of vitamin D deficiency in adult patients with, or at risk of developing, bone disease. There has been no clear consensus in the UK on vitamin D deficiency its assessment and treatment, and clinical practice is inconsistent. This guideline is aimed at clinicians, including doctors, nurses and dieticians. It recommends the measurement of serum 25 (OH) vitamin D (25OHD) to estimate vitamin D status in the following clinical scenarios: bone diseases that may be improved with vitamin D treatment; bone diseases, prior to specific treatment where correcting vitamin D deficiency is appropriate; musculoskeletal symptoms that could be attributed to vitamin D deficiency. The guideline also states that routine vitamin D testing is unnecessary where vitamin D supplementation with an oral antiresorptive treatment is already planned and sets the following serum 25OHD thresholds: &amp;lt;30 nmol\/l is deficient; 30\u201350 nmol\/l may be inadequate in some people; &amp;gt;50 nmol\/l is sufficient for almost the whole population.<\/jats:p>\n                  <jats:p>For treatment, oral vitamin D3 is recommended with fixed loading doses of oral vitamin D3 followed by regular maintenance therapy when rapid correction of vitamin D deficiency is required, although loading doses are not necessary where correction of deficiency is less urgent or when co-prescribing with an oral antiresorptive agent. For monitoring, serum calcium (adjusted for albumin) should be checked 1 month after completing a loading regimen, or after starting vitamin D supplementation, in case primary hyperparathyroidism has been unmasked. However, routine monitoring of serum 25OHD is generally unnecessary but may be appropriate in patients with symptomatic vitamin D deficiency or malabsorption and where poor compliance with medication is suspected.<\/jats:p>\n                  <jats:p>The guideline focuses on bone health as, although there are numerous putative effects of vitamin D on immunity modulation, cancer prevention and the risks of cardiovascular disease and multiple sclerosis, there remains considerable debate about the evaluation of extraskeletal factors and optimal vitamin D status in these circumstances.<\/jats:p>","DOI":"10.1093\/ageing\/afu093","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T21:20:43Z","timestamp":1406668843000},"page":"592-595","source":"Crossref","is-referenced-by-count":167,"title":["National Osteoporosis Society Vitamin D Guideline Summary"],"prefix":"10.1093","volume":"43","author":[{"given":"Terry J.","family":"Aspray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bowring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Gittoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kassim","family":"Javaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Selby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttan","family":"Tanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger M.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"2023022012282000500_","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1210\/er.2012-1000","article-title":"The non-skeletal effects of vitamin D: an endocrine society scientific statement","volume":"33","author":"Rosen","year":"2012","journal-title":"Endocr Rev"},{"key":"2023022012282000500_","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/ageing\/afi153","article-title":"Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey","volume":"34","author":"Hirani","year":"2005","journal-title":"Age Ageing"},{"key":"2023022012282000500_","volume-title":"Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. 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