{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:08:36Z","timestamp":1790345316786,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Association of Anaesthetists"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>anaemia following hip fracture is common and associated with worse outcomes. Intravenous iron is a potential non-transfusion treatment for this anaemia and has been found to reduce transfusion rates in previous observational studies. There is good evidence for its use in elective surgical populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>to examine the impact of intravenous iron on erythropoiesis following hip fracture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>two-centre, assessor-blinded, randomised, controlled trial of patients with primary hip fracture and no contra-indications to intravenous iron.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>the intervention group received three doses of 200 mg iron sucrose over 30 min (Venofer, Vifor Pharma, Bagshot Park, UK) on three separate days. Primary outcome was reticulocyte count at day 7 after randomisation. Secondary outcomes included haemoglobin concentration, complications and discharge destination. Eighty participants were randomised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>there was a statistically significantly greater absolute final reticulocyte count in the iron group (89.4 (78.9\u2013101.3) \u00d7 109 cells l\u22121 (n = 39) vs. the control (72.2 (63.9\u201386.4)) \u00d7 109 cells l\u22121 (n = 41); P = 0.019; (mean (95% confidence intervals) of log-transformed data). There were no differences in final haemoglobin concentration (99.9 (95.7\u2013104.2) vs. 102.0 (98.7\u2013105.3) P = 0.454) or transfusion requirements in the first week (11 (28%) vs. 12 (29%); P = 0.899). Functional and safety outcomes were not different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>although intravenous iron does stimulate erythropoiesis following hip fracture in older people, the effect is too small and too late to affect transfusion rates. Trial Registry Numbers: ISRCTN:76424792; EuDRACT: 2011-003233-34.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ageing\/afz049","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T20:08:29Z","timestamp":1557259709000},"page":"751-755","source":"Crossref","is-referenced-by-count":22,"title":["The effect of intravenous iron on erythropoiesis in older people with hip fracture"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3750-6067","authenticated-orcid":false,"given":"I K","family":"Moppett","sequence":"first","affiliation":[{"name":"Anaesthesia and Critical Care Research Group, Division of Clinical Neuroscience, Queen\u2019s Medical Centre, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rowlands","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Mannings","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Marufu","sequence":"additional","affiliation":[{"name":"Department of Healthcare of Older Life, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Sahota","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-4758","authenticated-orcid":false,"given":"J","family":"Yeung","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Warwick, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,25]]},"reference":[{"key":"2019090603050592700_afz049C1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/anae.12978","article-title":"A systematic review of pre-operative anaemia and blood transfusion in patients with fractured hips","volume":"70","author":"Potter","year":"2015","journal-title":"Anaesthesia"},{"key":"2019090603050592700_afz049C2","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMoa1012452","article-title":"Liberal or restrictive transfusion in high-risk patients after hip surgery","volume":"365","author":"Carson","year":"2011","journal-title":"N Engl J Med"},{"key":"2019090603050592700_afz049C3","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/anae.14358","article-title":"An international consensus statement on the management of postoperative anaemia after major surgical procedures","volume":"73","author":"Mu\u00f1oz","year":"2018","journal-title":"Anaesthesia"},{"key":"2019090603050592700_afz049C4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2106\/JBJS.I.00883","article-title":"Iron supplementation for anemia after hip fracture surgery: a randomized trial of 300 patients","volume":"92","author":"Parker","year":"2010","journal-title":"J Bone Joint Surg Am"},{"key":"2019090603050592700_afz049C5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/trf.12195","article-title":"Very\u2010short\u2010term perioperative intravenous iron administration and postoperative outcome in major orthopedic surgery: a pooled analysis of observational data from 2547 patients","volume":"54","author":"Mu\u00f1oz","year":"2014","journal-title":"Transfusion"},{"key":"2019090603050592700_afz049C6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.medcli.2012.09.029","article-title":"Preoperative intravenous iron as a strategy for blood saving in surgery for hip fracture","volume":"141","author":"Blanco Rubio","year":"2013","journal-title":"Med Cl\u00edn (Barc)"},{"key":"2019090603050592700_afz049C7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1423-0410.2005.00627.x","article-title":"Perioperative stimulation of erythropoiesis with intravenous iron and erythropoietin reduces transfusion requirements in patients with hip fracture. 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