{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:48:34Z","timestamp":1784674114958,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"crossref","award":["IIRG-09-133,014"],"award-info":[{"award-number":["IIRG-09-133,014"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ESPA-EU program Excellence Grant","award":["18910276\/8\/9\/2011"],"award-info":[{"award-number":["18910276\/8\/9\/2011"]}]},{"name":"Ministry for Health and Social Solidarity","award":["\u0394\u03a52\u03b2\/\u03bf\u03b9\u03ba0.51657\/14.4.2009"],"award-info":[{"award-number":["\u0394\u03a52\u03b2\/\u03bf\u03b9\u03ba0.51657\/14.4.2009"]}]},{"DOI":"10.13039\/501100003447","name":"State Scholarships Foundation","doi-asserted-by":"publisher","award":["MIS 5001552"],"award-info":[{"award-number":["MIS 5001552"]}],"id":[{"id":"10.13039\/501100003447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Apolipoprotein (APOE) \u03b54 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association between APOE \u03b54 allele and frailty syndrome. We operationalised Frailty according to the Fried definition, and we determined the APOE genotype in 1234 participants of the hellenic longitudinal investigation of ageing and diet study. Logistic regression analyses were performed to examine the association between APOE \u03b54 allele and frailty. Models were adjusted for age, education, sex, presence (or absence) of hypertension, diabetes, myocardial infraction, coronary disease, congestive heart failure, arrhythmia or other heart disease, family history of dementia and current smoking. The same models were performed after exclusion of patients with dementia and participants with APOE \u03b52\/\u03b54 genotype. In the fully adjusted model, carriers of APOE \u03b54 allele had 2.753 higher odds of frailty relative to non-carriers. After trichotomization of APOE genotype, APOE \u03b54 heterozygotes had 2.675 higher risk of frailty compared to non-carriers while exclusion of patients with dementia or\/and APOE \u03b52\/\u03b54 genotype did not alter the association. The APOE \u03b54 allele may be a significant biomarker of frailty with diagnostic and prognostic capacity.<\/jats:p>","DOI":"10.1093\/ageing\/afz098","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T15:09:28Z","timestamp":1562857768000},"page":"917-921","source":"Crossref","is-referenced-by-count":27,"title":["Apolipoprotein \u03b54 allele is associated with frailty syndrome: results from the hellenic longitudinal investigation of ageing and diet study"],"prefix":"10.1093","volume":"48","author":[{"given":"Niki","family":"Mourtzi","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ntanasi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"},{"name":"Department of Nutrition and Dietetics, Harokopio University, Athens, Greece"},{"name":"Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Yannakoulia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"Lab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"},{"name":"Department of Nutrition and Dietetics, Harokopio University, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Thessaly, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos","family":"Hadjigeorgiou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Sakka","sequence":"additional","affiliation":[{"name":"Athens Association of Alzheimer\u2019s Disease and Related Disorders, Marousi, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece"},{"name":"Department of Neurology, The Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer\u2019s Disease and the Aging Brain, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"key":"2019102510392898700_ref1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jamda.2013.03.022","article-title":"Frailty consensus: a call to action","volume":"14","author":"Morley","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"2019102510392898700_ref2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1017\/thg.2016.72","article-title":"The identification of hereditary and environmental determinants of frailty in a cohort of UK twins","volume":"19","author":"Young","year":"2016","journal-title":"Twin Res Hum Genet"},{"key":"2019102510392898700_ref3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1503\/cmaj.1031789","article-title":"Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging","volume":"171","author":"Hsiung","year":"2004","journal-title":"CMAJ"},{"key":"2019102510392898700_ref4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-141-2-200407200-00013","article-title":"Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease","volume":"141","author":"Song","year":"2004","journal-title":"Ann Intern Med"},{"key":"2019102510392898700_ref5","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1111\/j.1582-4934.2008.00270.x","article-title":"Apolipoprotein E-polymorphism, frailty and mortality in older adults","volume":"12","author":"Rockwood","year":"2008","journal-title":"J Cell Mol Med"},{"key":"2019102510392898700_ref6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000362723","article-title":"The hellenic longitudinal investigation of aging and diet (HELIAD): rationale, study design, and 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