{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:40:36Z","timestamp":1779374436087,"version":"3.53.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006544","name":"State of Israel Ministry Of Science & Technology","doi-asserted-by":"publisher","award":["3-12075"],"award-info":[{"award-number":["3-12075"]}],"id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>little is known on the clinical implications of vancomycin trough levels among older patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>to evaluate the association between vancomycin levels and outcomes among older versus younger patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>retrospective study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>patients aged 18\u201364 and\u2009\u226565\u00a0years treated with vancomycin for documented methicillin resistant Staphylococcus aureus (MRSA) infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>we compared the effectiveness and toxicity of vancomycin according to trough levels in older versus younger patients. Subgroup analysis of patients with glomerular filtration rate (GFR)\u2009&amp;gt;\u200960\u00a0ml\/min\/1.73\u00a0m2 was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>we included 181 patients aged \u226565\u00a0years and 104 younger patients. Mean age in the older group was 76.9\u2009\u00b1\u20098\u00a0years versus 50.9\u2009\u00b1\u200912.4 in the younger group. Vancomycin trough levels and 24-hours area under the curve to minimal inhibitory concentrations (AUC\/MIC) were significantly higher in older patients who were also significantly more likely to achieve trough levels of \u226515\u00a0mg\/l within 4\u00a0days, (98\/181 (54.1%) vs. 38\/104 (36.5%) in younger patients, P\u2009=\u20090.004). Results were similar among patients with GFR\u2009&amp;gt;\u200960. Thirty-day mortality was significantly higher in older (74\/181, 40.9% vs. 13\/104, 12.5%, respectively, P\u2009&amp;lt;\u20090.001). There was no association between vancomycin trough levels and mortality among older patients. No significant differences were demonstrated in clinical or microbiological success or nephrotoxicity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>applying uniform dosing recommendations across age groups among adults with MRSA infections results in higher vancomycin levels and AUC\/MIC in older versus younger patients. Yet, mortality rates remain higher among older adults. Prospective studies are needed to define the optimal approach for using this drug in older patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ageing\/afz135","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T15:23:55Z","timestamp":1569943435000},"page":"26-31","source":"Crossref","is-referenced-by-count":17,"title":["Attention to age: similar dosing regimens lead to different vancomycin levels among older and younger patients"],"prefix":"10.1093","volume":"49","author":[{"given":"Dafna","family":"Yahav","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Abbas","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Nassar","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"},{"name":"Section of Clinical Pharmacology and Toxicology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Ghrayeb","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Shepshelovich","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel"},{"name":"Medicine A, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kurnik","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"},{"name":"Section of Clinical Pharmacology and Toxicology, Rambam Health Care Campus, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Leibovici","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel"},{"name":"Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mical","family":"Paul","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel"},{"name":"Institute of Infectious Diseases, Rambam Health Care Campus, Haifa, 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