{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:49:33Z","timestamp":1762004973993,"version":"3.30.2"},"reference-count":65,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1968,6,1]],"date-time":"1968-06-01T00:00:00Z","timestamp":-50025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1968,6,1]],"date-time":"1968-06-01T00:00:00Z","timestamp":-50025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1968,6]]},"DOI":"10.1093\/ajcn\/21.6.693","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T03:46:42Z","timestamp":1517197602000},"page":"693-698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fructose Metabolism"],"prefix":"10.1016","volume":"21","author":[{"given":"ROBERT H.","family":"HERMAN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID","family":"ZAKIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/21.6.693_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000458127","article-title":"La lesion enzymatique de la fructosurie benigne.","volume":"1","author":"SCHAPIRA","year":"1961","journal-title":"Enzymol. Biol. Clin."},{"key":"10.1093\/ajcn\/21.6.693_bib2","first-page":"531","article-title":"Note preliminaire sur l\u2019etude clinique, biologique, histochimique et enzymatique de la fructosurie familiale essentielle.","volume":"7","author":"BAYLON","year":"1962","journal-title":"Rev. Franc. Etudes Clin. Biol."},{"key":"10.1093\/ajcn\/21.6.693_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1001\/archpedi.1942.02010020037004","article-title":"Essential fructosuria: its pathophysiology.","volume":"63","author":"SACHS","year":"1942","journal-title":"Am. J. Diseases Children"},{"key":"10.1093\/ajcn\/21.6.693_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0025-7125(16)35836-9","article-title":"Diagnosis of less common glycosurias, including pentosuria fructosuria.","volume":"31","author":"MARBLE","year":"1947","journal-title":"Med. Clin. N. Am."},{"key":"10.1093\/ajcn\/21.6.693_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1001\/archinte.1934.00160150099007","article-title":"Essential fructosuria: report of 3 cases with metabolic studies.","volume":"54","author":"SILVER","year":"1934","journal-title":"Arch. Internal Med."},{"key":"10.1093\/ajcn\/21.6.693_bib6","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0954-6820.1938.tb09989.x","article-title":"Etudes sur un cas de levulosurie essentielle.","volume":"97","author":"EDHEM","year":"1938","journal-title":"Acta Med. Scand."},{"key":"10.1093\/ajcn\/21.6.693_bib7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000197818","article-title":"Untersuchungen zur Pathologie des Fructose-Stoffwechsels: reine Fructosurie bei Beschwistern: Diabetes und Fructose-Stoffwechsel.","volume":"64","author":"STEINITZ","year":"1939","journal-title":"Gastroenterologia"},{"key":"10.1093\/ajcn\/21.6.693_bib8","first-page":"756","article-title":"ESsentiellc Fructosurie: Untersuchungen des intermediaren Stoffwechsels bei intravenoser Fructose-belastung.","volume":"93","author":"STEINITZ","year":"1963","journal-title":"Schweiz. Med. Wochschr."},{"key":"10.1093\/ajcn\/21.6.693_bib9","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0140-6736(67)90494-1","article-title":"Fructose-induced hyperuricemia.","volume":"2","author":"PERHEENTUPA","year":"1967","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib10","first-page":"328","article-title":"Uber Aldolasen. 4. Enzymaktivitaten in der Leber bei hereditarer Fructoseintoleranz.","volume":"337","author":"WOLF","year":"1963","journal-title":"Biochem. Z."},{"key":"10.1093\/ajcn\/21.6.693_bib11","first-page":"727","article-title":"Hereditary fructose intolerance, an inborn deficiency of liver aldolase complex.","volume":"11","author":"NIKKILA","year":"1962","journal-title":"Metab. Clin. Exptl."},{"key":"10.1093\/ajcn\/21.6.693_bib12","first-page":"486","article-title":"Hepatic aldolase in fructose intolerance.","volume":"12","author":"SCHAPIRA","year":"1967","journal-title":"Rev. Franc. Etudes Clin. Biol."},{"key":"10.1093\/ajcn\/21.6.693_bib13","first-page":"99","article-title":"Die hereditare Fructosein tolcranz.","volume":"14","author":"FROESCH","year":"1959","journal-title":"Helv. Paediat. Acta"},{"key":"10.1093\/ajcn\/21.6.693_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0002-9343(63)90050-0","article-title":"Hereditary fructose intolerance: Inborn defect of hepatic fructose-1-phosphate splitting aldolase.","volume":"34","author":"FROESCH","year":"1963","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/21.6.693_bib15","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1136\/adc.38.199.220","article-title":"Fructosaemia. An inborn error of fructose metabolism.","volume":"38","author":"LEVIN","year":"1963","journal-title":"Arch. Disease Childhood"},{"key":"10.1093\/ajcn\/21.6.693_bib16","first-page":"221","article-title":"Hereditary fructose intolerance. A clinical study of four cases.","volume":"8","author":"PERHEENTUPA","year":"1962","journal-title":"Ann. Paediat. Fenniae"},{"key":"10.1093\/ajcn\/21.6.693_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000458107","article-title":"Anomalie de l\u2019aldolase hepatique dans l\u2019intolerance au fructose.","volume":"1","author":"HERS","year":"1961","journal-title":"Enzymol. Biol. Clin."},{"key":"10.1093\/ajcn\/21.6.693_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3891\/acta.chem.scand.17s-0226","article-title":"Enzymic homolog}\u2019. Structural and catalytic differentiation of fructose diphosphate aldolase.","volume":"17","author":"RUTTER","year":"1963","journal-title":"Acta Chem. Scand."},{"key":"10.1093\/ajcn\/21.6.693_bib19","first-page":"236","article-title":"Ein bio-chemisches Studium uber zwei Faile von Fruktoseintoleranz.","volume":"8","author":"PITKANEN","year":"1962","journal-title":"Ann. Paediat. Fenniae"},{"key":"10.1093\/ajcn\/21.6.693_bib20","first-page":"49","article-title":"Technique nouvelle de misc en evidence d\u2019erreurs congenitales du metabolisme chez l\u2019homme.","volume":"13","author":"MILHAUD","year":"1964","journal-title":"Arquiv. Brasil. Endocrinol. Metabol."},{"key":"10.1093\/ajcn\/21.6.693_bib21","first-page":"317","article-title":"Zur Biochemie der hereditaren Fructoseintoleranz.","volume":"14","author":"SIDBURY","year":"1959","journal-title":"Helv. Paediat. Acta"},{"key":"10.1093\/ajcn\/21.6.693_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/bj1020753","article-title":"Inhibition of glucose phosphate isomerase by metabolic intermediates of fructose.","volume":"102","author":"ZALITIS","year":"1967","journal-title":"Biochem. J."},{"key":"10.1093\/ajcn\/21.6.693_bib23","first-page":"1168","article-title":"Die hereditare Fructoseintoleranz, einer bisher nicht bekannte kongenitale Stoffwechselstorung.","volume":"87","author":"FROESCH","year":"1957","journal-title":"Schu'eiz. Med. Wochschr."},{"key":"10.1093\/ajcn\/21.6.693_bib24","first-page":"90","article-title":"Etude d\u2019un cas d\u2019hypoglycemic fonctionelle par intolerance au fructose.","volume":"16","author":"DUBOIS","year":"1961","journal-title":"Helv. Paediat. Acta"},{"key":"10.1093\/ajcn\/21.6.693_bib25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0140-6736(62)92474-1","article-title":"Symptomless hereditary fructose intolerance.","volume":"1","author":"PERHEENTUPA","year":"1962","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib26","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1056\/NEJM196312122692401","article-title":"Hereditary fructose intolerance.","volume":"269","author":"CORNBLATH","year":"1963","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/21.6.693_bib27","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0140-6736(56)92196-1","article-title":"Idiosyncrasy to fructose.","volume":"2","author":"CHAMBERS","year":"1956","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib28","first-page":"605","article-title":"L\u2019intolerance hereditaire au fructose: A propos d\u2019un cas.","volume":"16","author":"JEUNE","year":"1961","journal-title":"Pediatrie"},{"key":"10.1093\/ajcn\/21.6.693_bib29","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(63)92367-5","article-title":"Insulin response to fructose and galactose.","volume":"1","author":"SAMOLS","year":"1963","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/bmj.4.5572.138","article-title":"Fructose intolerance.","volume":"4","author":"BLACK","year":"1967","journal-title":"Brit. Med. J."},{"key":"10.1093\/ajcn\/21.6.693_bib31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/BF01478217","article-title":"Angeborene hereditare Fructoseintoleranz.","volume":"37","author":"WOLF","year":"1959","journal-title":"Klin. Wochschr."},{"key":"10.1093\/ajcn\/21.6.693_bib32","first-page":"596","article-title":"Investigation of carbohydrate metabolism in hereditary intolerance to fructose: Attempt at interpretation of hypoglycemia.","volume":"9","author":"GENTIL","year":"1964","journal-title":"Rev. Franc. Etudes Clin. Biol."},{"key":"10.1093\/ajcn\/21.6.693_bib33","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0140-6736(62)92857-X","article-title":"Non-estcrified fatty acids and fatty liver in hereditary fructose intolerance.","volume":"2","author":"NIKKILA","year":"1962","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib34","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00000441-196605000-00003","article-title":"The association of hereditary fructose intolerance and renal tubular acidosis.","volume":"251","author":"MASS","year":"1966","journal-title":"Am. J. Med. Sci."},{"key":"10.1093\/ajcn\/21.6.693_bib35","first-page":"1076","article-title":"Fructoce-induccd disruption of renal acidification in patients with hereditary fructose intolerance.","volume":"44","author":"MORRIS","year":"1965","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/21.6.693_bib36","first-page":"1048","article-title":"Evidence for an acidification defect of the proximal renal tubule in experimental and clinical renal disease.","volume":"45","author":"MORRIS","year":"1966","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/21.6.693_bib37","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/214920b0","article-title":"Absence of renal fructose-1-phosphate aldolase activity in hereditary fructose intolerance.","volume":"214","author":"MORRIS","year":"1967","journal-title":"Nature"},{"key":"10.1093\/ajcn\/21.6.693_bib38","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0140-6736(61)91940-7","article-title":"Familial fructose and galactose intolerance.","volume":"1","author":"DORMANDY","year":"1961","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/21.6.693_bib39","first-page":"777","article-title":"Augmentation de l\u2019activitc de la glucose-6-phosphatase dans l\u2019intolerance au fructuose.","volume":"12","author":"HERS","year":"1962","journal-title":"Rev. Intern. Hepatol."},{"key":"10.1093\/ajcn\/21.6.693_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1172\/JCI104918","article-title":"Transient intolerance to exogenous fructose in the newborn.","volume":"43","author":"SCHWARTZ","year":"1964","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/21.6.693_bib41","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/214728a0","article-title":"Effect of intravenous infusion of fructose in newborn calves.","volume":"214","author":"EDWARDS","year":"1967","journal-title":"Nature"},{"key":"10.1093\/ajcn\/21.6.693_bib42","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/archsurg.1964.01320030098016","article-title":"Evaluation of the oral fructose test.","volume":"89","author":"KIRSH","year":"1964","journal-title":"Arch. Surg."},{"key":"10.1093\/ajcn\/21.6.693_bib43","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/2121490a0","article-title":"Activities of glycogen synthetase and UDPG-pyrophosphorylase in muscle of a patient with a new type of muscle glycogenolysis caused by phosphofructokinase deficiency.","volume":"212","author":"OKUNO","year":"1966","journal-title":"Nature"},{"key":"10.1093\/ajcn\/21.6.693_bib44","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/archneur.1967.00470290066009","article-title":"Muscle phosphofructokinase deficiency.","volume":"17","author":"LAYZER","year":"1967","journal-title":"Arch. Neurol."},{"key":"10.1093\/ajcn\/21.6.693_bib45","first-page":"13","article-title":"Myopathy due to a defect in muscle glycogen breakdown.","volume":"10","author":"MCARDLE","year":"1951","journal-title":"Cin. Sci."},{"key":"10.1093\/ajcn\/21.6.693_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archpedi.1966.02090080035001","article-title":"Glycogen storage disease, types II, III, VIII, and IX.","volume":"111","author":"HUG","year":"1966","journal-title":"Am. J. Diseases Children"},{"key":"10.1093\/ajcn\/21.6.693_bib47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1042\/bj1020035C","article-title":"Isolation of microsome-bound phosphofructokinase from frog skeletal muscle and its inhibition by calcium ions.","volume":"102","author":"MARGRETH","year":"1967","journal-title":"Biochem. J."},{"key":"10.1093\/ajcn\/21.6.693_bib48","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1098\/rspb.1964.0062","article-title":"The links between excitation and contraction.","volume":"160","author":"HUXLEY","year":"1964","journal-title":"Proc. Roy. Soc., London, Ser. B"},{"key":"10.1093\/ajcn\/21.6.693_bib49","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/2111032a0","article-title":"An electro-kinematic theory of muscle contraction.","volume":"211","author":"INGELS","year":"1966","journal-title":"Nature"},{"key":"10.1093\/ajcn\/21.6.693_bib50","first-page":"360","article-title":"Der Einfluss von Oxalat auf den Calcium-Transport isolierter Vesikel des sarkoplasmatischen Reticulum.","volume":"343","author":"MAKINOSE","year":"1965","journal-title":"Biochem. Z."},{"key":"10.1093\/ajcn\/21.6.693_bib51","first-page":"383","article-title":"Calcium-Akkumulation und Nucleosidtriphosphat-Spaltung durch die Vesikel des sarkoplasmatischen Reticulum.","volume":"343","author":"MAKINOSE","year":"1965","journal-title":"Biochem."},{"key":"10.1093\/ajcn\/21.6.693_bib52","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/bi00896a004","article-title":"Activation of skeletal muscle phosphorylase bkinase by Ca2+.","volume":"3","author":"MEYER","year":"1964","journal-title":"Biochemistry"},{"key":"10.1093\/ajcn\/21.6.693_bib53","series-title":"Control of Energy Metabolism","first-page":"299","article-title":"Control of Energy Metabolism","author":"HELMREICH","year":"1965"},{"key":"10.1093\/ajcn\/21.6.693_bib54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1083\/jcb.1.6.483","article-title":"The distribution of histochemically demonstrable succinic dehydrogenase and of mitochondria in tongue and skeletal muscles.","volume":"1","author":"WACHSTEIN","year":"1955","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1093\/ajcn\/21.6.693_bib55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1083\/jcb.4.1.47","article-title":"A histochemical study of normal denervated red and white muscles of the rat.","volume":"4","author":"NACHMIAS","year":"1958","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1093\/ajcn\/21.6.693_bib56","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/185701a0","article-title":"Reciprocal relationship of phosphorylase and oxidative enzymes in skeletal muscle.","volume":"185","author":"DUBOWITZ","year":"1960","journal-title":"Nature"},{"key":"10.1093\/ajcn\/21.6.693_bib57","first-page":"391","article-title":"Some applications of histochemistry to the study of skeletal muscle.","volume":"21","author":"BECKETT","year":"1962","journal-title":"Rev. Can. Biol."},{"key":"10.1093\/ajcn\/21.6.693_bib58","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1152\/ajplegacy.1966.210.5.1101","article-title":"Glycogen metabolism in red and white muscle.","volume":"210","author":"BOCEK","year":"1966","journal-title":"Am. J. Physiol."},{"key":"10.1093\/ajcn\/21.6.693_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1926.6.1.1","article-title":"Red and white muscle.","volume":"6","author":"NEEDHAM","year":"1926","journal-title":"Physiol. Rev."},{"key":"10.1093\/ajcn\/21.6.693_bib60","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1152\/ajplegacy.1963.205.6.1290","article-title":"Cell water, sodium, and potassium in red and white mammalian muscles.","volume":"205","author":"SRETER","year":"1963","journal-title":"Am. J. Physiol."},{"key":"10.1093\/ajcn\/21.6.693_bib61","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/bj1030391","article-title":"The activities of fructose-1, 6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle.","volume":"103","author":"OPIE","year":"1967","journal-title":"Biochem. J."},{"key":"10.1093\/ajcn\/21.6.693_bib62","first-page":"4","article-title":"Biochemical identification of the carrier state in Tay-Sachs disease.","volume":"64","author":"ARONSON","year":"1962","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"10.1093\/ajcn\/21.6.693_bib63","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1542\/peds.36.2.272","article-title":"Fructose tolerance in Tay-Sachs disease.","volume":"36","author":"SCHNECK","year":"1965","journal-title":"Pediatrics"},{"key":"10.1093\/ajcn\/21.6.693_bib64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0002-9343(64)90097-X","article-title":"Editorial: Fructose-1-phosphate aldolase deficiency in Tay-Sachs disease.","volume":"36","author":"VOLK","year":"1964","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/21.6.693_bib65","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/200995a0","article-title":"Anomaly of aldolase in primary liver cancer.","volume":"200","author":"SCHAPIRA","year":"1963","journal-title":"Nature"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523320987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523320987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/21\/6\/693\/24192291\/693.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:44:32Z","timestamp":1733964272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523320987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,6]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1968,6]]}},"alternative-id":["S0002916523320987"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/21.6.693","relation":{},"ISSN":["0002-9165"],"issn-type":[{"type":"print","value":"0002-9165"}],"subject":[],"published":{"date-parts":[[1968,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fructose Metabolism","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/21.6.693","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1968 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}