{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:52:43Z","timestamp":1773827563872,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[1972,11,1]],"date-time":"1972-11-01T00:00:00Z","timestamp":89424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1972,11]]},"DOI":"10.1093\/ajcn\/25.11.1193","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T11:42:18Z","timestamp":1516707738000},"page":"1193-1201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diagnosis and classification of reactive hypoglycemia based on hormonal changes in response to oral and intravenous glucose administration"],"prefix":"10.1016","volume":"25","author":[{"given":"Fred D.","family":"Hofeldt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Dippe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Forsham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/25.11.1193_bib1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1001\/jama.1940.02810460001001","article-title":"The spontaneous hypoglycemias. Importance of etiology in determining treatment.","volume":"115","author":"CONN","year":"1940","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/25.11.1193_bib2","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0002-9343(55)90130-3","article-title":"Spontaneous hypoglycemia.","volume":"19","author":"CONN","year":"1955","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib3","first-page":"7","article-title":"On spontaneous hypoglycemia.Current Concepts","author":"CONN","year":"1970","journal-title":"Scope Monograph, The Upjohn Company"},{"key":"10.1093\/ajcn\/25.11.1193_bib4","first-page":"3","article-title":"Pathophysiology and therapy of the fasting hypoglycemias.","author":"ARKY","year":"1968","journal-title":"Disease-A-Month"},{"key":"10.1093\/ajcn\/25.11.1193_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/0002-9610(63)90485-9","article-title":"The physiologic basis for evaluation of \u201cfasting hypoglycemias.\u201d","volume":"105","author":"FREINKEL","year":"1963","journal-title":"Am. J. Surg."},{"key":"10.1093\/ajcn\/25.11.1193_bib6","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJM196904102801508","article-title":"Oral glucose tolerance curve and hypoglycemias in the fed state.","volume":"280","author":"FREINKEL","year":"1969","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib7","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/ajcn\/22.5.646","article-title":"Classification of reactive hypoglycemia.","volume":"22","author":"ANDERSON","year":"1969","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/25.11.1193_bib8","first-page":"64","article-title":"Reactive hypoglycemia: mechanisms and management.","volume":"114","author":"KARAM","year":"1971","journal-title":"Calif. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2337\/diab.14.6.341","article-title":"Dynamics of insulin secretion in hypoglycemia.","volume":"14","author":"YALOW","year":"1965","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib10","first-page":"390","article-title":"Hypoglycemia.","volume":"41","author":"RandALL","year":"1966","journal-title":"Mayo Clinic Proc."},{"key":"10.1093\/ajcn\/25.11.1193_bib11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2337\/diab.17.11.684","article-title":"Early phase of insulin release.","volume":"17","author":"SIMPSON","year":"1968","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib12","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/bjs.1800560315","article-title":"The adrenocortical response to surgery and insulin-induced hypoglycemia in corticosteroid-treated and normal subjects.","volume":"56","author":"PLUMPTON","year":"1969","journal-title":"Brit. J. Surg."},{"key":"10.1093\/ajcn\/25.11.1193_bib13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1172\/JCI105357","article-title":"The plasma sugar, free fatty acid, cortisol and growth hormone response to insulin. I. In control subjects.","volume":"45","author":"GREENWOOD","year":"1966","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib14","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/jcp.19.3.284","article-title":"Assessment of hypothalamic pituitary function in endocrine disease.","volume":"19","author":"GREENWOOD","year":"1966","journal-title":"J. Clin. Pathol."},{"key":"10.1093\/ajcn\/25.11.1193_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1210\/jcem-32-2-188","article-title":"Further studies on the relation between growth hormone and corticotrophin secretion in insulin-induced hypoglycemia.","volume":"32","author":"NAKAGAWA","year":"1971","journal-title":"J. Clin. Endocrinol."},{"key":"10.1093\/ajcn\/25.11.1193_bib16","first-page":"448","article-title":"The photometric microdetermination of blood glucose oxidase.","volume":"51","author":"SAIFER","year":"1960","journal-title":"J. Lab. Clin. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib17","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1172\/JCI104122","article-title":"An immunochemical assay of total extractable insulin in man.","volume":"39","author":"GRODSKY","year":"1960","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/jcp.15.4.374","article-title":"A simple fluorometric method for the estimation of free 11-hydroxycorticoids in human plasma.","volume":"15","author":"MATTINGLY","year":"1962","journal-title":"J. Clin. Pathol."},{"key":"10.1093\/ajcn\/25.11.1193_bib19","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/archinte.1966.03870120028006","article-title":"Carbohydrate intolerance in postgastrectomy patients.","volume":"117","author":"ROBERTSON","year":"1966","journal-title":"Arch. Internal Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib20","first-page":"119","article-title":"Carbohydrate metabolism in subtotal gastrectomy patient.","volume":"46","author":"BERKOWITZ","year":"1966","journal-title":"Am. J. Gastroenterol."},{"key":"10.1093\/ajcn\/25.11.1193_bib21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/gut.10.10.825","article-title":"Insulin response to carbohydrate ingestion after gastric surgery with special reference to hypoglycemia.","volume":"10","author":"CAMERON","year":"1969","journal-title":"Gut"},{"key":"10.1093\/ajcn\/25.11.1193_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/00325481.1966.11695904","article-title":"Functional hypoglycemia and peptic ulcer.","volume":"40","author":"ZIEVE","year":"1966","journal-title":"Postgrad. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diab.15.1.1","article-title":"Plasma insulin levels during reactive hypoglycemia.","volume":"15","author":"SUSSMAN","year":"1966","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1749-6632.1968.tb27760.x","article-title":"Functional hypoglycemia in early latent diabetes.","volume":"148","author":"FALUDI","year":"1968","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1093\/ajcn\/25.11.1193_bib25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/00325481.1969.11697300","article-title":"Insights about diabetes and hyperinsulinism gained from the insulin immunoassay.","volume":"46","author":"SELTZER","year":"1969","journal-title":"Postgrad. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2337\/diab.5.6.437","article-title":"Spontaneous hypoglycemia as an early manifestation of diabetes mellitus.","volume":"5","author":"SELTZER","year":"1956","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib27","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/ajcn\/21.12.1445","article-title":"Insulin secretion in obesity: pseudodiabetes?","volume":"21","author":"KARAM","year":"1968","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/25.11.1193_bib28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1172\/JCI104130","article-title":"Immunoassay of endogenous plasma insulin in man.","volume":"39","author":"YALOW","year":"1960","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1172\/JCI105534","article-title":"Insulin secretion in response to glycemic stimulus: relation of delayed release to carbohydrate intolerance in mild diabetes mellitus.","volume":"46","author":"SELTZER","year":"1967","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0026-0495(69)90127-9","article-title":"Role of gastrointestinal factor in reactive hypoglycemia.","volume":"18","author":"VEVERBRANTS","year":"1969","journal-title":"Metab. Clin. Exptl."},{"key":"10.1093\/ajcn\/25.11.1193_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/gut.10.6.422","article-title":"The gut and oral glucose tolerance.","volume":"10","author":"HOLDSWORTH","year":"1969","journal-title":"Gut"},{"key":"10.1093\/ajcn\/25.11.1193_bib32","first-page":"131","article-title":"The effect of diabetes mellitus and insulin on glucose absorption by the small intestine in man.","volume":"66","author":"VINNIK","year":"1965","journal-title":"J. Lab. Clin. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/bmj.4.5678.257","article-title":"Pathophysiology of postgastrectomy hypoglycemia.","volume":"4","author":"HOLDSWORTH","year":"1969","journal-title":"Brit. Med. J."},{"key":"10.1093\/ajcn\/25.11.1193_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02346246","article-title":"The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones.","volume":"7","author":"HINZ","year":"1971","journal-title":"Diabetologia"},{"key":"10.1093\/ajcn\/25.11.1193_bib35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archinte.1969.00300130043007","article-title":"Enteroinsular axis.","volume":"123","author":"UNGER","year":"1969","journal-title":"Arch. Internal Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib36","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI106111","article-title":"The gastrointestinal stimulus to insulin release","volume":"48","author":"CHISHOLM","year":"1969","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib37","first-page":"30","article-title":"Gastrointestinal hormones and clinical gastroenterology.","volume":"56","author":"BROOKS","year":"1970","journal-title":"U. S. Navy Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib38","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(68)91081-7","article-title":"Secretin and pancreozymin-cholecystokinin after glucose.","volume":"2","author":"YOUNG","year":"1968","journal-title":"Lancet"},{"issue":"Suppl. 126","key":"10.1093\/ajcn\/25.11.1193_bib39","first-page":"115","article-title":"Alimentary hypoglycemia after stomach operations and influence of gastric emptying on glucose tolerance curve.","author":"EVENSEN","year":"1942","journal-title":"Acta Med. Scand."},{"issue":"Suppl. 126","key":"10.1093\/ajcn\/25.11.1193_bib40","first-page":"143","article-title":"Alimentary hypoglycemia after stomach operations and influence of gastric emptying on glucose tolerance curve. XI. Influence of gastric emptying on the rate of intestinal absorption.","author":"EVENSEN","year":"1942","journal-title":"Acta Med. Scand."},{"key":"10.1093\/ajcn\/25.11.1193_bib41","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0140-6736(68)90747-2","article-title":"Influence of gastric emptying rate and of insulin response on oral glucose tolerance in thyroid diseases.","volume":"2","author":"HOLDSWORTH","year":"1968","journal-title":"Lancet"},{"issue":"Suppl. 126","key":"10.1093\/ajcn\/25.11.1193_bib42","article-title":"Alimentary hypoglycemia after stomach operations and influence of gastric emptying on glucose tolerance curve. X. The tolerance curve after duodenal administration of glucose.","volume":"137","author":"EVENSEN","year":"1942","journal-title":"Acta Med. Scand."},{"key":"10.1093\/ajcn\/25.11.1193_bib43","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJM197005142822006","article-title":"Effect of gastrointestinal hormones on insulin and glucagon secretion.","volume":"282","author":"CREUTZFELDT","year":"1970","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib44","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(68)91820-5","article-title":"Effects of insulin on intestinal glucose absorption.","volume":"2","author":"LOVE","year":"1968","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/25.11.1193_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0002-9343(68)90037-5","article-title":"Hormonal genesis of glucose intolerance following hypoglycemia.","volume":"45","author":"MINTZ","year":"1968","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib46","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1172\/JCI104525","article-title":"Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion.","volume":"41","author":"UNGER","year":"1962","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/25.11.1193_bib47","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0002-9343(65)90131-2","article-title":"Significance of epinephrine in insulin hypoglycemia in man.","volume":"38","author":"WALLACE","year":"1965","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib48","first-page":"241","article-title":"The regulation of growth hormone secretion.","volume":"21","author":"GLICK","year":"1965","journal-title":"Recent Progr. Hormone Res."},{"key":"10.1093\/ajcn\/25.11.1193_bib49","series-title":"In: Textbook of Endocrinology","first-page":"803","article-title":"Hypoglycemia and hypoglycemosis.","author":"WILLIAMS","year":"1968"},{"key":"10.1093\/ajcn\/25.11.1193_bib50","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/jcem-22-9-873","article-title":"Secondary rise in plasma free fatty acids following glucose load.","volume":"22","author":"BOLINGER","year":"1962","journal-title":"J. Clin. Endocrinol."},{"key":"10.1093\/ajcn\/25.11.1193_bib51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2337\/diab.16.8.576","article-title":"Studies of substrate-regulation in fasting. I. Evidence for central regulation of lipolysis by plasma glucose mediated by the sympathetic nervous system.","volume":"16","author":"GOODNER","year":"1967","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib52","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/00325481.1970.11697483","article-title":"Psychosomatic aspects of endocrinologic disorders.","volume":"47","author":"WITTKOWER","year":"1970","journal-title":"Postgrad. Med."},{"key":"10.1093\/ajcn\/25.11.1193_bib53","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1001\/jama.1950.02910340027008","article-title":"Life situations, emotions and hyperinsulinism.","volume":"142","author":"PORTIS","year":"1950","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/25.11.1193_bib54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2337\/diab.14.4.186","article-title":"Observations on blood glucose concentration of human subjects during continuous sampling.","volume":"14","author":"BURNS","year":"1965","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib55","doi-asserted-by":"crossref","first-page":"428","DOI":"10.2337\/diab.20.6.428","article-title":"Reactive hypoglycemia in women: results of a health survey.","volume":"20","author":"JUNG","year":"1971","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib56","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1749-6632.1968.tb27750.x","article-title":"Combined sulfonylurea-phenformin therapy of the dysinsulinism of early diabetes mellitus.","volume":"148","author":"HORTON","year":"1962","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"Suppl. 2","key":"10.1093\/ajcn\/25.11.1193_bib57","first-page":"747","article-title":"A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes","year":"1970","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/25.11.1193_bib58","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00000441-197101000-00002","article-title":"Treatment of reactive hypoglycemia with sulfonylureas.","volume":"261","author":"ANDERSON","year":"1971","journal-title":"Am. J. Med. Sci."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523331472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523331472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/25\/11\/1193\/24187503\/1193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T13:47:25Z","timestamp":1698760045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523331472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,11]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1972,11]]}},"alternative-id":["S0002916523331472"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/25.11.1193","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1972,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis and classification of reactive hypoglycemia based on hormonal changes in response to oral and intravenous glucose administration","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/25.11.1193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1972 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}