{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:10:10Z","timestamp":1751242210823,"version":"3.41.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1972,2,1]],"date-time":"1972-02-01T00:00:00Z","timestamp":65750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1972,2]]},"DOI":"10.1093\/ajcn\/25.2.135","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T10:03:01Z","timestamp":1516701781000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of blood clearance of ethanol and tolbutamide and the activity of hepatic ethanol-oxidizing and drug-metabolizing enzymes in chronic alcoholic subjects"],"prefix":"10.1016","volume":"25","author":[{"given":"Madhukar N.","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L.","family":"Iber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/25.2.135_bib1","first-page":"532","article-title":"Differences in ethanol metabolism in alcoholic and nonalcoholic subjects.","volume":"21","author":"KATER","year":"1968","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/25.2.135_bib2","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/ajcn\/22.12.1608","article-title":"Differences in the rate of ethanol metabolism in recently drinking alcoholic and nondrinking subjects.","volume":"22","author":"KATER","year":"1969","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/25.2.135_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1001\/jama.1969.03150150075025","article-title":"Increased rate of tolbutamide metabolism in an alcoholic patient.","volume":"207","author":"KATER","year":"1969","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/25.2.135_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00000441-196907000-00005","article-title":"Increased rate of clearance of drugs from the circulation of alcoholics.","volume":"258","author":"KATER","year":"1969","journal-title":"Am. J. Med. Sci."},{"key":"10.1093\/ajcn\/25.2.135_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0031-6997(25)07146-7","article-title":"Pharmacological implications of microsomal enzyme induction.","volume":"19","author":"CONNEY","year":"1967","journal-title":"Pharmacol. Rev."},{"key":"10.1093\/ajcn\/25.2.135_bib6","unstructured":"ROGGIN, G., M. N. SHAH AND F. L. IBER. Rapid blood removal of tolbutamide in alcoholics\u2014duration after abstinence and production by alcohol ingestion. (Submitted for publication.)"},{"key":"10.1093\/ajcn\/25.2.135_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1126\/science.162.3856.917","article-title":"Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.","volume":"162","author":"LIEBER","year":"1968","journal-title":"Science"},{"key":"10.1093\/ajcn\/25.2.135_bib8","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.159.3822.1469","article-title":"Ethanol increases hepatic smooth endoplasmic reticulum and drug metabolizing enzymes.","volume":"159","author":"RUBIN","year":"1968","journal-title":"Science"},{"key":"10.1093\/ajcn\/25.2.135_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01480893","article-title":"\u00dcber eine M\u00f6glichkeit zur colorimetrischen Bestimmung von N-(4-Methyl-Benzoylsulfonyl)-N-Butyl-Hamstoff im Serum.","volume":"35","author":"SPINGLER","year":"1957","journal-title":"Klin. Wochschr."},{"key":"10.1093\/ajcn\/25.2.135_bib10","first-page":"240","article-title":"Ethanol alcohol in blood and tissue. VI. Enzymic methods.","volume":"7","author":"LUNDQUIST","year":"1959","journal-title":"Methods Biochem. Analy."},{"key":"10.1093\/ajcn\/25.2.135_bib11","first-page":"116","article-title":"Quantitative measurement of alcohol dehydrogenase in the lobule of normal livers. J.","volume":"70","author":"MORRISON","year":"1967","journal-title":"Lab. Clin. Med."},{"key":"10.1093\/ajcn\/25.2.135_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0006-291X(66)90643-7","article-title":"Activation and inhibition of microsomal hydroxylation by ethyl isocyanide.","volume":"25","author":"IMAI","year":"1966","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/ajcn\/25.2.135_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0022-3565(25)11824-7","article-title":"Enzymatic oxidation of pentobarbital and thiopental.","volume":"120","author":"COOPER","year":"1957","journal-title":"J. Pharmacol. Exptl. Therap."},{"key":"10.1093\/ajcn\/25.2.135_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0022-3565(25)05211-5","article-title":"Fate of pentobarbital in man and dog and a method for estimation in biological material.","volume":"109","author":"BRODIE","year":"1953","journal-title":"J. Pharmacol. Exptl. Therap."},{"key":"10.1093\/ajcn\/25.2.135_bib15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","article-title":"Tyrosine and tryptophane determinations in proteins. J.","volume":"73","author":"FOLIN","year":"1927","journal-title":"Biol. Chem."},{"key":"10.1093\/ajcn\/25.2.135_bib16","first-page":"626","article-title":"The kinetics of alcohol removal from the blood of man: comparison in recently drinking alcoholics and non-alcoholics.","volume":"28","author":"IBER","year":"1969","journal-title":"Federation Proc."},{"key":"10.1093\/ajcn\/25.2.135_bib17","first-page":"258","article-title":"Ethanol metabolism and ethanol oxidizing enzymes in chronic alcoholic patients.","volume":"58","author":"MEZEY","year":"1970","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/25.2.135_bib18","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/S0021-9258(18)63099-6","article-title":"Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo.","volume":"245","author":"LIEBER","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1093\/ajcn\/25.2.135_bib19","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0006-291X(70)90610-8","article-title":"Ethanol oxidation by liver microsomes: evidence against a separate and distinct enzyme system.","volume":"39","author":"ISSELBACHER","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/ajcn\/25.2.135_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0002-9343(70)80061-4","article-title":"Inhibition of drug metabolism by acute ethanol intoxication: a hepatic microsomal mechanism.","volume":"49","author":"RUBIN","year":"1970","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/25.2.135_bib21","first-page":"110","article-title":"Effect of ethanol administration on hepatic ethanol and drug metabolizing enzymes and the rate of ethanol degradation.","volume":"77","author":"TOBON","year":"1971","journal-title":"J. Lab. Clin. Med."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523329708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523329708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/25\/2\/135\/24187600\/135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T23:47:36Z","timestamp":1751240856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523329708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,2]]}},"alternative-id":["S0002916523329708"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/25.2.135","relation":{},"ISSN":["0002-9165"],"issn-type":[{"type":"print","value":"0002-9165"}],"subject":[],"published":{"date-parts":[[1972,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of blood clearance of ethanol and tolbutamide and the activity of hepatic ethanol-oxidizing and drug-metabolizing enzymes in chronic alcoholic subjects","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/25.2.135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1972 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}