{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:09:16Z","timestamp":1791162556732,"version":"4.1.0"},"reference-count":113,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1975,7]]},"DOI":"10.1093\/ajcn\/28.7.764","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T09:06:21Z","timestamp":1516611981000},"page":"764-774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":202,"title":["Coronary heart disease: the zinc\/copper hypothesis"],"prefix":"10.1016","volume":"28","author":[{"given":"LM","family":"Klevay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/28.7.764_bib1","series-title":"Vital Statistics of the United States 1967. Mortality","year":"1969"},{"key":"10.1093\/ajcn\/28.7.764_bib2","article-title":"Arteriosclerosis, a Report by the National Heart and Lung Institute Task Force on Arteriosclerosis","volume":"2","author":"NEWMAN","year":"1971","journal-title":"Arteriosclerosis, a Report by the National Heart and Lung Institute Task Force on Arteriosclerosis"},{"key":"10.1093\/ajcn\/28.7.764_bib3","article-title":"Snow on Cholera","author":"SNOW","year":"1965"},{"key":"10.1093\/ajcn\/28.7.764_bib4","article-title":"Goldberger on Pellagra","author":"GOLDBERGER","year":"1964"},{"key":"10.1093\/ajcn\/28.7.764_bib5","unstructured":"PLANCK, M. The Philosophy of Physics. New York: W. W. Norton, 1963, p. 57."},{"key":"10.1093\/ajcn\/28.7.764_bib6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/ajcn\/26.10.1060","article-title":"Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested.","volume":"26","author":"KLEVAY","year":"1973","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0021-9681(59)90114-6","article-title":"Statistical associations between international coronary heart disease death rates and certain environmental factors.","volume":"9","author":"JOLLIFFE","year":"1960","journal-title":"J. Chronic Diseases"},{"issue":"42 Suppl. I","key":"10.1093\/ajcn\/28.7.764_bib8","first-page":"1","article-title":"Coronary heart disease in seven countries.","volume":"41","author":"KEYS","year":"1970","journal-title":"Circulation"},{"key":"10.1093\/ajcn\/28.7.764_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/01.CIR.22.2.265","article-title":"Atherosclerosis and related factors in immigrants to Israel.","volume":"22","author":"TOOR","year":"1960","journal-title":"Circulation"},{"key":"10.1093\/ajcn\/28.7.764_bib10","doi-asserted-by":"crossref","unstructured":"HANKIN, J., D. REED, D. LABARTHE, M. NICHAMAN AND R. STALLONES. Dietary and disease patterns among Micronesians. Am. J. Clin. Nutr. 23: 346. 1970.","DOI":"10.1093\/ajcn\/23.3.346"},{"key":"10.1093\/ajcn\/28.7.764_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/000331976601700210","article-title":"Dietetic aspects of atherosclerosis","volume":"17","author":"YUDKIN","year":"1966","journal-title":"Angiology"},{"key":"10.1093\/ajcn\/28.7.764_bib12","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ajcn\/25.9.926","article-title":"Ischemic heart disease and dietary fiber.","volume":"25","author":"TROWELL","year":"1972","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/ajcn\/27.11.1202","article-title":"Coronary heart disease and dietary fiber.","volume":"27","author":"KLEVAY","year":"1974","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7326\/0003-4819-48-1-83","article-title":"Lessons from serum cholesterol studies in Japan, Hawaii and Los Angeles.","volume":"48","author":"KEYS","year":"1958","journal-title":"Ann. Intern. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJM196707272770405","article-title":"Dietary fats, carbohydrates and atherosclerotic vascular disease.","volume":"277","author":"MCGANDY","year":"1967","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib16","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/ja01414a027","article-title":"The phytin content of foodstuffs.","volume":"48","author":"AVERILL","year":"1926","journal-title":"J. Am. Chem. Soc."},{"key":"10.1093\/ajcn\/28.7.764_bib17","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1042\/bj0292694","article-title":"Phytin in human nutrition.","volume":"29","author":"MCCANCE","year":"1935","journal-title":"Biochem. J."},{"key":"10.1093\/ajcn\/28.7.764_bib18","series-title":"Metabolism","first-page":"225","article-title":"The availability of zinc from foodstuffs. In: Zinc","author":"OBERLEAS","year":"1966"},{"key":"10.1093\/ajcn\/28.7.764_bib19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3181\/00379727-120-30559","article-title":"Phytic acid-metal complexes.","volume":"120","author":"VOHRA","year":"1965","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib20","unstructured":"REINHOLD, J. G. The availability of zinc to man in diets rich in phytate and fiber. In: Trace Elements and Human Disease, edited by A. S. Prasad. New York: Academic. In press."},{"key":"10.1093\/ajcn\/28.7.764_bib21","first-page":"8A","article-title":"Effect of phytate on zinc absorption and faecal excretion and carcass retention of zinc, iron, copper and manganese.","volume":"33","author":"DAVIES","year":"1974","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/ajcn\/28.7.764_bib22","first-page":"426","article-title":"Zinc\/copper hypercholesterolemia: The effect of sodium phytate.","volume":"18","author":"KLEVAY","year":"1975","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib23","first-page":"393","article-title":"Inferences about the epidemiology of coronary heart disease.","volume":"9","author":"KLEVAY","year":"1974","journal-title":"Nutr. Rept. Intern."},{"key":"10.1093\/ajcn\/28.7.764_bib24","first-page":"237","article-title":"The ratio of zinc to copper of diets in the United States","volume":"11","author":"KLEVAY","year":"1975","journal-title":"Nutr. Rept. Intern."},{"key":"10.1093\/ajcn\/28.7.764_bib25","series-title":"Metabolism","first-page":"274","article-title":"Copper metabolism in human subjects. In: Copper","author":"CARTWRIGHT","year":"1950"},{"key":"10.1093\/ajcn\/28.7.764_bib26","first-page":"9","article-title":"Trace elements in human nutrition.","author":"DARBY","year":"1973","journal-title":"World Health Organ., Tech. Rept. Ser. no. 532"},{"key":"10.1093\/ajcn\/28.7.764_bib27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.0954-6820.1965.tb04329.x","article-title":"Trace elements in human myocardial infarction determined by neutron activation analysis","volume":"178","author":"WESTER","year":"1965","journal-title":"Acta Med. Scand."},{"key":"10.1093\/ajcn\/28.7.764_bib28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1152\/physrev.1973.53.3.535","article-title":"Copper homeostasis in the mammalian system","volume":"53","author":"EVANS","year":"1973","journal-title":"Physiol. Rev."},{"key":"10.1093\/ajcn\/28.7.764_bib29","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/ajplegacy.1967.213.5.1183","article-title":"Blood copper variation among species.","volume":"213","author":"EVANS","year":"1967","journal-title":"Am. J. Physiol."},{"key":"10.1093\/ajcn\/28.7.764_bib30","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/0006-291X(70)90201-9","article-title":"Induction of ceruloplasmin synthesis by copper.","volume":"41","author":"EVANS","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/ajcn\/28.7.764_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/geronj\/20.2.151","article-title":"The free radical theory of aging: Effect of age on serum copper levels","volume":"20","author":"HARMAN","year":"1965","journal-title":"J. Gerontol."},{"key":"10.1093\/ajcn\/28.7.764_bib32","series-title":"Le R\u00f4le de la Paroi Art\u00e9rielle dans L\u2019Ath\u00e9rog\u00e9n\u00e8se","first-page":"93","article-title":"Stages in development of coronary disease observed from 1, 500 young subjects","author":"OSBORN","year":"1968"},{"key":"10.1093\/ajcn\/28.7.764_bib33","series-title":"Proceedings of the 8th Annual Conference on Trace Substances in Environmental Health","first-page":"9","article-title":"The ratio of zinc to copper in milk and mortality due to coronary heart disease: An association","author":"KLEVAY","year":"1975"},{"key":"10.1093\/ajcn\/28.7.764_bib34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0002-8703(60)90192-7","article-title":"The low incidence of myocardial infarction in patients with portal cirrhosis of the liver: A review of 639 cases of cirrhosis of the liver from 17, 731 autopsies.","volume":"60","author":"HOWELL","year":"1960","journal-title":"Am. Heart J."},{"key":"10.1093\/ajcn\/28.7.764_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00000441-196502000-00003","article-title":"The effect of chronic alcoholism and cirrhosis of the liver on atherosclerosis.","volume":"249","author":"HIRST","year":"1965","journal-title":"Am. J. Med. Sci."},{"key":"10.1093\/ajcn\/28.7.764_bib36","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1056\/NEJM195711282572201","article-title":"Zinc metabolism in hepatic dysfunction. II Correlation of metabolic patterns with biochemical findings.","volume":"257","author":"VALLEE","year":"1957","journal-title":"New Engl. J. Med"},{"key":"10.1093\/ajcn\/28.7.764_bib37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(62)80054-7","article-title":"The relation of zincuria to water and electrolyte excretion in patients with hepatic cirrhosis","volume":"42","author":"SULLIVAN","year":"1962","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/28.7.764_bib38","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ajcp\/44.4.426","article-title":"Urine and serum zinc abnormalities in disease of the liver.","volume":"44","author":"KAHN","year":"1965","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1093\/ajcn\/28.7.764_bib39","first-page":"365","article-title":"The microchemical demonstration of copper in pigment cirrhosis.","volume":"7","author":"MALLORY","year":"1931","journal-title":"Am. J. Pathol."},{"key":"10.1093\/ajcn\/28.7.764_bib40","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJM197005142822005","article-title":"Regulation of cholesterol metabolism.","volume":"282","author":"DIETSCHY","year":"1970","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib41","unstructured":"HASLEWOOD, G. A. D. Bile salts. In: Comprehensive Biochemistry. Vol. 10, Sterols, Bile Acids and Steroids, edited by M. Florkin and E. H. Stotz. Amsterdam: Elsevier, 1963, p. 23."},{"key":"10.1093\/ajcn\/28.7.764_bib42","first-page":"178","article-title":"Exercise and heart disease.","volume":"21","year":"1963","journal-title":"Nutr. Rev."},{"key":"10.1093\/ajcn\/28.7.764_bib43","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(73)90128-1","article-title":"Vigorous exercise in leisure time and the incidence of coronary heart disease.","volume":"1","author":"MORRIS","year":"1973","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/28.7.764_bib44","first-page":"84","article-title":"Zinc, iron and nitrogen content of sweat in normal and deficient subjects.","volume":"62","author":"PRASAD","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9258(18)56964-7","article-title":"The dermal excretion under controlled environmental conditions of nitrogen and minerals in human subjects, with particular reference to calcium and iron.","volume":"178","author":"MITCHELL","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1093\/ajcn\/28.7.764_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00003086-196907000-00010","article-title":"Muscle and bone hypertrophy.","volume":"65","author":"SAVILLE","year":"1969","journal-title":"Clin. Orthopaed. Related Res."},{"key":"10.1093\/ajcn\/28.7.764_bib47","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00004032-196302000-00002","article-title":"Trace elements in human tissue. Part II. Adult subjects from the United States.","volume":"9","author":"TIPTON","year":"1963","journal-title":"Health Phys."},{"key":"10.1093\/ajcn\/28.7.764_bib48","first-page":"5","article-title":"Gamma-ray spectrometric analysis of some micro elements in human mandibular compact bone.","volume":"2","author":"SOREMARK","year":"1962","journal-title":"Acta Isotopic."},{"key":"10.1093\/ajcn\/28.7.764_bib49","first-page":"183","article-title":"Body composition changes in obese and lean men during physical conditioning.","volume":"3","author":"BOILEAU","year":"1971","journal-title":"Med. Sci. Sports"},{"key":"10.1093\/ajcn\/28.7.764_bib50","first-page":"210","article-title":"The effects of a jogging program on the body composition of normal & obese high school girls.","volume":"4","author":"MOODY","year":"1972","journal-title":"Med. Sci. Sports"},{"key":"10.1093\/ajcn\/28.7.764_bib51","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1749-6632.1963.tb15798.x","article-title":"Physical activity and body composition: Fitness and fatness","volume":"110","author":"JOKL","year":"1963","journal-title":"Ann. N; Y. Acad. Sci."},{"key":"10.1093\/ajcn\/28.7.764_bib52","series-title":"Recommended Dietary Allowances","first-page":"22","year":"1974"},{"key":"10.1093\/ajcn\/28.7.764_bib53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0002-9343(48)90370-2","article-title":"Effects of immobilization upon various metabolic and physiologic functions of normal men.","volume":"4","author":"DEITRICK","year":"1948","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib54","series-title":"Human Nutrition and Dietetics","first-page":"93","author":"DAVIDSON","year":"1972"},{"key":"10.1093\/ajcn\/28.7.764_bib55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJM197403282901301","article-title":"Accelerated atherosclerosis in prolonged maintenance hemodialysis.","volume":"290","author":"LINDNER","year":"1974","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib56","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1056\/NEJM197403282901311","article-title":"Cardiovascular disease in dialysis patients.","volume":"290","author":"LOWRIE","year":"1974","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib57","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2214\/ajr.101.4.915","article-title":"Roentgenographic manifestations of chronic renal disease treated by periodic hemodialysis.","volume":"101","author":"JOHNSON","year":"1967","journal-title":"Am. J. Roentgenol. Radium Therapy Nucl. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib58","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1152\/ajplegacy.1972.222.2.322","article-title":"Alleviation of teratogenic effects of zinc deficiency by simultaneous lack of calcium.","volume":"222","author":"HURLEY","year":"1972","journal-title":"Am. J. Physiol."},{"key":"10.1093\/ajcn\/28.7.764_bib59","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/ajpa.1330140405","article-title":"Estimation of skeleton weight in the living.","volume":"14","author":"MERZ","year":"1956","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1093\/ajcn\/28.7.764_bib60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ajpa.1330170106","article-title":"The weight of the dry fat-free skeleton of American Whites and Negroes.","volume":"17","author":"SEALE","year":"1959","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1093\/ajcn\/28.7.764_bib61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bmj.2.5650.141","article-title":"Active uptake of copper and zinc during haemodialysis.","volume":"2","author":"BLOMFIELD","year":"1969","journal-title":"Brit. Med. J."},{"key":"10.1093\/ajcn\/28.7.764_bib62","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0140-6736(70)90701-4","article-title":"Plasma-zinc in health and disease.","volume":"I","author":"HALSTED","year":"1970","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/28.7.764_bib63","unstructured":"WINTROBE, M. M., G. W. THORN, R. D. ADAMS, E. BRAUNWALD, K. J. ISSELBACHER AND R. G. PETERSDORF. In: Harrison's Principles of Internal Medicine (7th ed.). New York: McGraw-Hill, 1974, p. 2039."},{"key":"10.1093\/ajcn\/28.7.764_bib64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1464-410X.1972.tb10077.x","article-title":"Whole blood, red cell and plasma total and ultrafiltrable zinc levels in normal subjects and patients with chronic renal failure with and without haemodialysis.","volume":"44","author":"ROSE","year":"1972","journal-title":"Brit. J. Urol."},{"key":"10.1093\/ajcn\/28.7.764_bib65","first-page":"164","article-title":"Atherosclerosis and the hardness of drinking water.","volume":"25","year":"1967","journal-title":"Nutr. Rev."},{"key":"10.1093\/ajcn\/28.7.764_bib66","first-page":"295","article-title":"Cardiovascular mortality and soft drinking water.","volume":"26","year":"1968","journal-title":"Nutr. Rev."},{"key":"10.1093\/ajcn\/28.7.764_bib67","series-title":"Public water supplies of the 100 largest cities in the United States, 1962.","author":"DURFOR","year":"1964"},{"key":"10.1093\/ajcn\/28.7.764_bib68","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(68)90297-3","article-title":"Mortality and hardness of local water supplies.","volume":"1","author":"CRAWFORD","year":"1968","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/28.7.764_bib69","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1753-4887.1968.tb00862.x","article-title":"Present knowledge of calcium, phosphorus and magnesium.","volume":"26","author":"HEGSTED","year":"1968","journal-title":"Nutr. Rev."},{"key":"10.1093\/ajcn\/28.7.764_bib70","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/jn\/88.3.331","article-title":"Effect of calcium, phosphorus and zinc on zinc-65 absorption and turnover in rats fed semipurified diets.","volume":"88","author":"HETH","year":"1966","journal-title":"J. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib71","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0140-6736(73)91808-4","article-title":"Ischaemic-heart-disease mortality and dietary intake of calcium.","volume":"1","author":"KNOX","year":"1973","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/28.7.764_bib72","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/ajcn\/27.1.59","article-title":"Magnesium interrelationships in ischemic heart disease: A review.","volume":"27","author":"SEELIG","year":"1974","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib73","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1001\/jama.1960.03020170028007","article-title":"Relation between mortality from cardiovascular disease and treated water supplies","volume":"172","author":"SCHROEDER","year":"1960","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/28.7.764_bib74","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.1966.03100020069016","article-title":"Municipal drinking water and cardiovascular death rates","volume":"195","author":"SCHROEDER","year":"1966","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/28.7.764_bib75","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/00039896.1974.10666497","article-title":"Cardiovascular mortality, municipal water, and corrosion.","volume":"28","author":"SCHROEDER","year":"1974","journal-title":"Arch. Environ. Health"},{"key":"10.1093\/ajcn\/28.7.764_bib76","series-title":"Coronary Risk Handbook.","author":"INSULL","year":"1973"},{"key":"10.1093\/ajcn\/28.7.764_bib77","first-page":"68","article-title":"Urinary excretion of cadmium, zinc and copper in normo-tensive and hypertensive women.","volume":"79","author":"MCKENZIE","year":"1973","journal-title":"New Zealand Med. J."},{"key":"10.1093\/ajcn\/28.7.764_bib78","unstructured":"FREDRICKSON, D. S., AND R. I. LEVY. Familial hyperlipoproteinemia. In: The Metabolic Basis of Inherited Disease (3rd ed.), edited by J. B. Stanbury, J. B. Wyngaarden and D. S. Fredrickson. New York: McGraw-Hill, 1972, p. 545."},{"key":"10.1093\/ajcn\/28.7.764_bib79","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jama.1966.03100020074017","article-title":"Coronary heart disease in the Western Collaborative Group Study.","volume":"195","author":"ROSENMAN","year":"1966","journal-title":"J. Am. Med. Assoc."},{"key":"10.1093\/ajcn\/28.7.764_bib80","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJM197102042840506","article-title":"Psychologic and social precursors of coronary disease.","volume":"284","author":"JENKINS","year":"1971","journal-title":"New Engl. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib81","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/bmj.1.5446.1352","article-title":"Effects of oral calcium upon serum lipids in man.","volume":"I","author":"YACOWITZ","year":"1965","journal-title":"Brit. Med. J."},{"key":"10.1093\/ajcn\/28.7.764_bib82","first-page":"418","article-title":"Die Beeinflussung des Gesamtcholesterins, der \u03b2-Lipoproteide und Gesamtlipide des Serums durch orale und parenterale Calciumzufuhr","volume":"97","author":"MAIBACH","year":"1967","journal-title":"Schweiz. Med. Wochschr."},{"key":"10.1093\/ajcn\/28.7.764_bib83","first-page":"1059","article-title":"Uber die Beeinflussung des Gesamtcholesterins und der Gesamtlipide im Serum des Menschen durch orale Kalziumzufuhr","volume":"118","author":"MAIBACH","year":"1969","journal-title":"Wien. Med. Wochschr."},{"key":"10.1093\/ajcn\/28.7.764_bib84","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0021-9150(71)90067-0","article-title":"Effects of oral calcium upon serum cholesterol and triglycerides in patients with hyperlipidemia.","volume":"14","author":"CARLSON","year":"1971","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/28.7.764_bib85","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF02533064","article-title":"Long term human studies on the lipid effects of oral calcium.","volume":"7","author":"BIERENBAUM","year":"1972","journal-title":"Lipids"},{"key":"10.1093\/ajcn\/28.7.764_bib86","first-page":"119","article-title":"Effects of a calcium supplement on serum cholesterol, calcium, phosphorus and bone density of \u201cnormal, healthy\u201d elderly females.","volume":"8","author":"ALBANESE","year":"1973","journal-title":"Nutr. Rept. Intern."},{"key":"10.1093\/ajcn\/28.7.764_bib87","unstructured":"COTTON, F. A., AND G. WILKINSON. Advanced Inorganic Chemistry (3rd ed.). New York: Interscience, 1972, p. 206, 208, 513."},{"key":"10.1093\/ajcn\/28.7.764_bib88","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1172\/JCI103922","article-title":"Normal concentrations of some trace metals in human urine: Changes produced by ethylenediaminetetraacetate.","volume":"38","author":"PERRY","year":"1959","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/28.7.764_bib89","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0002-9343(57)90349-2","article-title":"Lesions resembling vitamin B complex deficiency and urinary loss of zinc produced by ethylenediamine tetra-acetate.","volume":"22","author":"PERRY","year":"1957","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib90","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/165453a0","article-title":"Stability of some metal complexes of histidine.","volume":"165","author":"MALEY","year":"1950","journal-title":"Nature"},{"key":"10.1093\/ajcn\/28.7.764_bib91","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/bj1210549","article-title":"The computed distribution of copper II and zinc (II) ions among seventeen amino acids present in human blood plasma.","volume":"121","author":"HALLMAN","year":"1971","journal-title":"Biochem. J."},{"key":"10.1093\/ajcn\/28.7.764_bib92","series-title":"Williams Obstetrics","first-page":"177","author":"HELLMAN","year":"1971"},{"key":"10.1093\/ajcn\/28.7.764_bib93","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0002-9378(15)30172-1","article-title":"The mechanism of histidinuria of pregnancy","volume":"51","author":"PAGE","year":"1946","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1093\/ajcn\/28.7.764_bib94","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0002-9378(54)90471-8","article-title":"The causes of histidinuria in normal pregnancy.","volume":"68","author":"PAGE","year":"1954","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1093\/ajcn\/28.7.764_bib95","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3181\/00379727-133-34446","article-title":"Plasma and tissue cholesterol and lipid levels in rabbits on L-histidine-supplemented diets.","volume":"133","author":"GEISON","year":"1970","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib96","unstructured":"LA DU, B. N. Histidinemia. In: The Metabolic Basis of Inherited Disease (3rd ed.), edited by J. B. Stanbury, J. B. Wyngaarden and D. S. Fredrickson. New York: McGraw-Hill, 1972, p. 338."},{"key":"10.1093\/ajcn\/28.7.764_bib97","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1542\/peds.29.5.714","article-title":"Inborn error of histidine metabolism.","volume":"29","author":"GHADIMI","year":"1962","journal-title":"Pediatrics"},{"key":"10.1093\/ajcn\/28.7.764_bib98","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1152\/ajplegacy.1970.218.3.613","article-title":"Mechanism for hormone-induced alterations in serum ceruloplasmin.","volume":"218","author":"EVANS","year":"1970","journal-title":"Am. J. Physiol."},{"key":"10.1093\/ajcn\/28.7.764_bib99","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/ajcn\/23.9.1194","article-title":"Hair as a biopsy material. II. Assessment of copper nutriture.","volume":"23","author":"KLEVAY","year":"1970","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/bmj.1.5330.571","article-title":"Diet and plasma cholesterol in 99 bank men.","volume":"1","author":"MORRIS","year":"1963","journal-title":"Brit. Med. J."},{"key":"10.1093\/ajcn\/28.7.764_bib101","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1079\/PNS19730034","article-title":"Why bread in the diet lowers serum cholesterol","volume":"32","author":"GROEN","year":"1973","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/ajcn\/28.7.764_bib102","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1079\/PNS19730033","article-title":"Dietary fibre, ischaemic heart disease and diabetes mellitus","volume":"32","author":"TROWELL","year":"1973","journal-title":"Proc. Nutr. Soc."},{"key":"10.1093\/ajcn\/28.7.764_bib103","first-page":"345","article-title":"Dietary fibre and coronary heart disease","volume":"17","author":"TROWELL","year":"1972","journal-title":"Rev. Eur. \u00a3tud. Clin. Biol."},{"key":"10.1093\/ajcn\/28.7.764_bib104","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1172\/JCI102939","article-title":"Studies on copper metabolism. XL Copper and iron metabolism in the nephrotic syndrome.","volume":"33","author":"CARTWRIGHT","year":"1954","journal-title":"J. Clin. Invest."},{"key":"10.1093\/ajcn\/28.7.764_bib105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/clinchem\/17.5.369","article-title":"Simultaneous direct estimation by atomic absorption spectrophotometry of copper and zinc in serum, urine and cerebrospinal fluid.","volume":"17","author":"MERET","year":"1971","journal-title":"Clin. Chem."},{"key":"10.1093\/ajcn\/28.7.764_bib106","unstructured":"KOFF, R. S., AND K. J. ISSELBACHER. Acute hepatitis. In: Harrison's Principles of Internal Medicine (7th ed.), edited by M. M. Wintrobe, G. W. Thorn, R. D. Adams, E. Braunwald, K. J. Isselbacher and R. G. Petersdorf. New York: McGraw-Hill, 1974, p. 1528."},{"key":"10.1093\/ajcn\/28.7.764_bib107","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00000441-197211000-00008","article-title":"Zinc and copper metabolism in acute viral hepatitis.","volume":"264","author":"HENKIN","year":"1972","journal-title":"Am. J. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib108","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1001\/archinte.1936.00170150097007","article-title":"Clinical significance of the cholesterol partition of the blood plasma in hepatic and in biliary diseases.","volume":"58","author":"EPSTEIN","year":"1936","journal-title":"Arch. Intern. Med."},{"key":"10.1093\/ajcn\/28.7.764_bib109","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0026-0495(72)90005-4","article-title":"Effects of an experimental viral infection on plasma lipid and lipoprotein metabolism.","volume":"21","author":"LEES","year":"1972","journal-title":"Metabolism"},{"key":"10.1093\/ajcn\/28.7.764_bib110","first-page":"193","article-title":"Redistribution and sequestering of essential trace elements during acute infection","volume":"2","author":"PEKAREK","year":"1975"},{"key":"10.1093\/ajcn\/28.7.764_bib111","first-page":"899","article-title":"Hypercholesterolemia in rats induced by ascorbic acid.","volume":"34","author":"KLEVAY","year":"1975","journal-title":"Federation Proc."},{"key":"10.1093\/ajcn\/28.7.764_bib112","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/ajcn\/27.10.1039","article-title":"Ascorbic acid and cholesterol levels in pastoral peoples in Kenya.","volume":"27","author":"DAVIES","year":"1974","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/ajcn\/28.7.764_bib113","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0140-6736(71)90601-5","article-title":"Atherosclerosis and vitamin C.","volume":"2","author":"SPITTLE","year":"1971","journal-title":"Lancet"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523338115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523338115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/28\/7\/764\/23558859\/764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T13:59:10Z","timestamp":1698760750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523338115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7]]},"references-count":113,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1975,7]]}},"alternative-id":["S0002916523338115"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/28.7.764","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1975,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coronary heart disease: the zinc\/copper hypothesis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/28.7.764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1972 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}