{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:03:24Z","timestamp":1774357404609,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1986,10,1]],"date-time":"1986-10-01T00:00:00Z","timestamp":528508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1986,10]]},"DOI":"10.1093\/ajcn\/44.4.453","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:00:08Z","timestamp":1515592808000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Changes in plasma amino acids during sobriety in alcoholic patients with and without liver disease"],"prefix":"10.1016","volume":"44","author":[{"given":"AME","family":"Diehl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MC","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HF","family":"Herlong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JJ","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wacker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Mezey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/44.4.453_bib1","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1136\/gut.19.11.1068","article-title":"Plasma ratio of valine, leucine, and isoleucine to phenylalanine and tyrosine in liver disease","volume":"19","author":"Morgan","year":"1978","journal-title":"Gut"},{"key":"10.1093\/ajcn\/44.4.453_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0016-5085(81)90486-8","article-title":"The nature and prognostic significance of serial amino acid determinations in severe chronic active liver disease","volume":"81","author":"McCullough","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/44.4.453_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0016-5085(78)90243-3","article-title":"Plasma amino acid abnormalities in the alcoholic. Respective role of alcohol, nutrition, and liver injury","volume":"74","author":"Shaw","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/44.4.453_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0003-9861(53)90409-3","article-title":"Studies on Vitamin Be and transamination in rat liver","volume":"45","author":"Caldwell","year":"1953","journal-title":"Arch Biochem Biophys"},{"key":"10.1093\/ajcn\/44.4.453_bib5","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1016\/S0021-9258(20)81341-6","article-title":"Pyridoxal phosphate requirement for intestinal absorption of L-tyrosine","volume":"235","author":"Jacobs","year":"1960","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/44.4.453_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0021-9258(18)70409-2","article-title":"Intestinal absorption of the methionine isomers as affected by deoxypyridoxine","volume":"232","author":"Jacobs","year":"1958","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/44.4.453_bib7","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S0021-9258(18)69414-1","article-title":"Influence of pyridoxine, pyridoxal phosphate, deoxypyridoxine, and 2,4-dinittophenol on methionine absorption","volume":"235","author":"Jacobs","year":"1960","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/44.4.453_bib8","first-page":"266","article-title":"Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease","volume":"52","author":"Majumdar","year":"1982","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/ajcn\/44.4.453_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7326\/0003-4819-77-2-249","article-title":"Criteria for the diagnosis of alcoholism","volume":"77","year":"1972","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/44.4.453_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hep.1840010607","article-title":"Alcoholic liver disease: I. Interrelationships among histologic features and the histologic effects of prednisolone therapy","volume":"1","author":"Boitnott","year":"1981","journal-title":"Hepatology"},{"key":"10.1093\/ajcn\/44.4.453_bib11","series-title":"Manual of nutrition therapeutics","first-page":"153","author":"Alpers","year":"1983"},{"key":"10.1093\/ajcn\/44.4.453_bib12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0016-5085(84)80110-9","article-title":"Relationship between pyridoxal 5-phosphate deficiency and aminotransferase levels in alcoholic hepatitis","volume":"86","author":"Diehl","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/44.4.453_bib13","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1021\/ac50047a019","article-title":"High-performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with o-phthalaldehyde","volume":"51","author":"Lindroth","year":"1979","journal-title":"Anal Chem"},{"key":"10.1093\/ajcn\/44.4.453_bib14","series-title":"Statistical methods","author":"Snedecor","year":"1967"},{"key":"10.1093\/ajcn\/44.4.453_bib15","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(63)90734-7","article-title":"The plasma aminogram in Kwashiorkor","volume":"2","author":"Holt","year":"1963","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/44.4.453_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF01311702","article-title":"Relationship of plasma amino acids to nitrogen balance and portal-systemic encephalopathy in alcoholic liver disease","volume":"27","author":"Weber","year":"1982","journal-title":"Dig Dis Sci"},{"key":"10.1093\/ajcn\/44.4.453_bib17","first-page":"554","article-title":"Serum amino acid concentrations in alcoholic hepatitis","volume":"70","author":"Ning","year":"1967","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/44.4.453_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1056\/NEJM197401312900502","article-title":"Hyperglucagonemia in Laennec\u2019s cirrhosis. The role of portal-systemic shunting","volume":"290","author":"Sherwin","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/44.4.453_bib19","first-page":"1092","article-title":"Protein turnover and amino add metabolism in the regulation of gluconeogenesis","volume":"33","author":"Felig","year":"1974","journal-title":"Fed Proc"},{"key":"10.1093\/ajcn\/44.4.453_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01312226","article-title":"Effects of insulin and glucagon on the uptake of amino adds from arterial blood by canine ileum","volume":"26","author":"Weber","year":"1981","journal-title":"Dig Dis Sci"},{"key":"10.1093\/ajcn\/44.4.453_bib21","series-title":"Amino add pools","first-page":"708","article-title":"The role of the liver and non-hepatic tissues in the regulation of free amino add levels in blood","author":"Miller","year":"1962"},{"key":"10.1093\/ajcn\/44.4.453_bib22","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.824734","article-title":"Plasma alpha amino-n-butyric add to leudne ratio: an empirical biochemical marker of alcoholism","volume":"194","author":"Shaw","year":"1976","journal-title":"Science"},{"key":"10.1093\/ajcn\/44.4.453_bib23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0016-5085(19)31661-0","article-title":"Plasma \u03b1-amino-n-butyric add to leudne ratio: non-spedfidty as a marker for alcoholism","volume":"75","author":"Deinstag","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/44.4.453_bib24","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0016-5085(76)80056-X","article-title":"Abnormal regulation of plasma pyridoxal-5\u2019-phosphate in patients with liver disease","volume":"71","author":"Mitchell","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/44.4.453_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/gut.18.1.23","article-title":"Vitamin Be defidendes in chronic liver disease\u2014evidence for increased degradation of pyridoxal-5-phosphate","volume":"18","author":"Labadarios","year":"1977","journal-title":"Gut"},{"key":"10.1093\/ajcn\/44.4.453_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1056\/NEJM197008272830901","article-title":"Studies on the pathogenesis of alcohol-induced sideroblastic bone marrow abnormalities","volume":"283","author":"Hines","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/44.4.453_bib27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1172\/JCI107607","article-title":"Vitamin Be metabolism in chronic alcohol abuse. Pyridoxal phosphate levels in plasma and the effects of acetaldehyde on pyridoxal phosphate synthesis and degradation of human erythrocytes","volume":"53","author":"Lumeng","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/44.4.453_bib28","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI108003","article-title":"Vitamin Be metabolism in chronic alcohol abuse. The effect of ethanol oxidation on hepatic pyridoxal 5-phosphate metabolism","volume":"55","author":"Vdtch","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/44.4.453_bib29","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.1975.tb19174.x","article-title":"Hematologic abnormalities involving Vitamin Be and folate metabolism in alcoholic subjects","volume":"252","author":"Hines","year":"1975","journal-title":"Ann NY Acad Sci"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523399660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523399660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/44\/4\/453\/24124727\/453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T07:52:10Z","timestamp":1686297130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523399660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["S0002916523399660"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/44.4.453","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1986,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in plasma amino acids during sobriety in alcoholic patients with and without liver disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/44.4.453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1986 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}