{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:40:48Z","timestamp":1760985648431},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1988,10]]},"DOI":"10.1093\/ajcn\/48.4.992","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T12:42:15Z","timestamp":1515415335000},"page":"992-997","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Omega-3 fatty acids in hypertriglyceridemic patients: triglycerides vs methyl esters"],"prefix":"10.1016","volume":"48","author":[{"given":"WS","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ML","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CA","family":"Dujovne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/48.4.992_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.ATV.2.2.87","article-title":"Polyun-saturated fatty acids, hyperlipidemia and thrombosis.","volume":"2","author":"Goodnight","year":"1982","journal-title":"Arteriosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.7326\/0003-4819-107-6-890","article-title":"The prophylaxis of atherosclerosis with marine omega-3 fatty acids: a comprehensive strategy.","volume":"107","author":"Von Schacky","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/48.4.992_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/ajcn\/43.4.566","article-title":"Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials.","volume":"43","author":"Herold","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/48.4.992_bib4","first-page":"1","article-title":"Lipid metabolism and ischemic heart disease in Greenland eskimos.","volume":"3","author":"Bang","year":"1980","journal-title":"Adv Nutr Res"},{"key":"10.1093\/ajcn\/48.4.992_bib5","first-page":"50","article-title":"Food for the heart.","author":"Hagar","year":"1985","journal-title":"American Health"},{"key":"10.1093\/ajcn\/48.4.992_bib6","first-page":"127","article-title":"Anonymous. Take fish to heart.","year":"1985","journal-title":"Reader's Digest"},{"key":"10.1093\/ajcn\/48.4.992_bib7","first-page":"148","article-title":"The effects of salmon oil upon plasma lipids, lipoproteins and triglyceride clearance.","volume":"43","author":"Harris","year":"1980","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1093\/ajcn\/48.4.992_bib8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0026-0495(83)90226-3","article-title":"The comparative reductions of the plasma lipids and lipoproteins by dietary polyunsaturated fats: salmon oil versus vegetable oils.","volume":"32","author":"Harris","year":"1983","journal-title":"Metabolism"},{"key":"10.1093\/ajcn\/48.4.992_bib9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/01.ATV.4.3.270","article-title":"Inhibition of low density lipoprotein synthesis by dietary \u03c9-3 fatty acids in man.","volume":"4","author":"Illingworth","year":"1984","journal-title":"Arteriosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib10","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/0026-0495(84)90230-0","article-title":"\u03c9-3 fatty acids prevent carbohydrate-induced hypertriglyceridemia.","volume":"33","author":"Harris","year":"1984","journal-title":"Metabolism"},{"key":"10.1093\/ajcn\/48.4.992_bib11","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1056\/NEJM198505093121902","article-title":"Reductions of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia.","volume":"312","author":"Phillipson","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/48.4.992_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0021-9150(84)90003-0","article-title":"The long-term effects of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina.","volume":"50","author":"Saynor","year":"1984","journal-title":"Atherosclerosis"},{"issue":"Suppl 31","key":"10.1093\/ajcn\/48.4.992_bib13","first-page":"78","article-title":"Controlled trials of fish oil supplements on plasma lipid concentrations.","volume":"38","author":"Sanders","year":"1984","journal-title":"Brit J Clin Pract"},{"key":"10.1093\/ajcn\/48.4.992_bib14","first-page":"479","article-title":"Dietary fish oil, plasma lipid and platelets: a dose response study.","volume":"3","author":"Harris","year":"1983","journal-title":"Arteriosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0021-9150(85)90155-8","article-title":"On the effects of dietary n-3 fatty acids (MaxEPA) on plasma lipids and lipoproteins in patients with hyperlipidemia.","volume":"54","author":"Simons","year":"1985","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0021-9150(86)90072-9","article-title":"Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil.","volume":"61","author":"Sullivan","year":"1986","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1001\/jama.1977.03280060041018","article-title":"Predicting coronary heart disease in middle aged or older persons. The Framingham Study.","volume":"238","author":"Gordon","year":"1977","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/48.4.992_bib18","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/ajcn\/40.4.780","article-title":"Will dietary n-3 fatty acids change the composition of human milk?","volume":"40","author":"Harris","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/48.4.992_bib19","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0002-8223(21)04145-6","article-title":"Methods to assess relative reliability of diet records: minimum records for monitoring lipid and caloric intake.","volume":"86","author":"Jackson","year":"1986","journal-title":"J Am Diet Assoc"},{"key":"10.1093\/ajcn\/48.4.992_bib20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","article-title":"Enzymatic determination of total serum cholesterol.","volume":"20","author":"Allain","year":"1974","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/48.4.992_bib21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/clinchem\/19.5.476","article-title":"Quantatitive determination of serum triglycerides by the use of enzymes.","volume":"19","author":"Bucolo","year":"1973","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/48.4.992_bib22","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0022-2275(20)38059-7","article-title":"Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure.","volume":"23","author":"Gidez","year":"1982","journal-title":"J Lipid Res"},{"key":"10.1093\/ajcn\/48.4.992_bib23","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/clinchem\/23.11.2089","article-title":"New micromethod for measuring cholesterol in plasma lipoprotein fractions.","volume":"23","author":"Bronzert","year":"1977","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/48.4.992_bib24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-2275(20)34498-9","article-title":"Determination of B protein of low density lipoprotein directly in plasma.","volume":"16","author":"Sniderman","year":"1975","journal-title":"J Lipid Res"},{"key":"10.1093\/ajcn\/48.4.992_bib25","series-title":"Statistical principles in experimental design.","author":"Winer","year":"1971"},{"key":"10.1093\/ajcn\/48.4.992_bib26","first-page":"614","article-title":"Letter to the editor.","volume":"2","author":"Reed","year":"1982","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/48.4.992_bib27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/BF02533177","article-title":"Resistence of certain long chain polyunsaturated fatty acids of marine oils to pancreatic lipase hydrolysis.","volume":"2","author":"Bottino","year":"1967","journal-title":"Lipids"},{"key":"10.1093\/ajcn\/48.4.992_bib28","unstructured":"Chernenko G, Barrowman JA, Kean K, Herzberg GR, Keough KMW. Intestinal absorption of fish oil triglycerides in the rat. In: Chandra RK, ed. Health effects of fish and fish oils. St Johns, Newfoundland: ARTS Publishing Co (in press)."},{"key":"10.1093\/ajcn\/48.4.992_bib29","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/ajcn\/34.9.1752","article-title":"The effect of various intakes of n-3 fatty acids on the blood lipid composition in healthy human subjects.","volume":"34","author":"Bronsgeest-Schoute","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/48.4.992_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0021-9150(83)90073-4","article-title":"Effect of eicosapentaenoic acid on the platelet aggregation and composition of fatty acid in man.","volume":"47","author":"Nagakawa","year":"1983","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib31","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1172\/JCI112147","article-title":"Long-term effects of dietary marine \u03c9-3 fatty acids upon plasma and cellular lipids, platelet function and eicosanoid formation in humans.","volume":"76","author":"von Schacky","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/48.4.992_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0021-9150(83)90181-8","article-title":"Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity, and red cell deformability in healthy human subjects.","volume":"46","author":"Terano","year":"1983","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/bmj.288.6417.592","article-title":"Beneficial effect of fish oil on blood viscosity in peripheral vascular disease.","volume":"288","author":"Woodcock","year":"1984","journal-title":"Br Med J"},{"key":"10.1093\/ajcn\/48.4.992_bib34","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1182\/blood.V58.5.880.880","article-title":"The effect of dietary \u03c9-3 fatty acids on platelet composition and function in man: a prospective, controlled study.","volume":"58","author":"Goodnight","year":"1981","journal-title":"Blood"},{"key":"10.1093\/ajcn\/48.4.992_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0021-9150(85)90021-8","article-title":"Blood pressure and lipid lowering effect of mackerel and herring diet in patients with mild essential hypertension.","volume":"56","author":"Singer","year":"1985","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib36","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/ajcn\/31.8.1340","article-title":"The effect of a fish diet on serum lipids in healthy human subjects.","volume":"31","author":"von Lossonczy","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/48.4.992_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.0954-6820.1983.tb03705.x","article-title":"Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type Ha).","volume":"213","author":"Brox","year":"1983","journal-title":"Acta Med Scand"},{"key":"10.1093\/ajcn\/48.4.992_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0262-1746(85)90036-8","article-title":"Plasma essential fatty acids in pure and mixed race American Indians on and off a diet exceptionally rich in salmon.","volume":"17","author":"Bates","year":"1985","journal-title":"Prostaglandins Leukotrienes Med"},{"key":"10.1093\/ajcn\/48.4.992_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/0021-9150(88)90158-X","article-title":"The effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects.","author":"Zucker","year":"1988","journal-title":"Atherosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib40","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.ATV.5.5.459","article-title":"Triglyceridelowering effect of marine polyunsaturates in patients with hypertriglyceridemia.","volume":"5","author":"Sanders","year":"1985","journal-title":"Arteriosclerosis"},{"key":"10.1093\/ajcn\/48.4.992_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/01.CIR.72.1.93","article-title":"The ratio of plasma HDL-C to total and LDL-C: age-related changes and race and sex differences in selected North American populations.","volume":"72","author":"Green","year":"1985","journal-title":"Circulation"},{"key":"10.1093\/ajcn\/48.4.992_bib42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0022-2275(20)37797-X","article-title":"Modification in the composition and metabolic properties of human low density and high density lipoproteins by different dietary fats.","volume":"25","author":"Baudet","year":"1984","journal-title":"J Lipid Res"},{"key":"10.1093\/ajcn\/48.4.992_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0163-7827(84)90008-0","article-title":"Effect of unsaturated acids on membrane structure and enzyme kinetics.","volume":"23","author":"Brenner","year":"1984","journal-title":"Prog Lipid Res"},{"key":"10.1093\/ajcn\/48.4.992_bib44","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1172\/JCI111644","article-title":"Metabolism of apolipoprotein B in large, triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects.","volume":"74","author":"Packard","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/48.4.992_bib45","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/S0022-2275(20)38070-6","article-title":"Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts.","volume":"23","author":"Gianturco","year":"1982","journal-title":"J Lipid Res"},{"key":"10.1093\/ajcn\/48.4.992_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1172\/JCI111422","article-title":"Suppression by diets rich in fish oil of very low density lipoprotein production in man.","volume":"74","author":"Nestel","year":"1984","journal-title":"J Clin Invest"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523162575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523162575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/48\/4\/992\/24065811\/992.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T03:43:51Z","timestamp":1686282231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523162575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["S0002916523162575"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/48.4.992","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1988,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Omega-3 fatty acids in hypertriglyceridemic patients: triglycerides vs methyl esters","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/48.4.992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1988 American Institute of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}