{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:49:06Z","timestamp":1770911346237,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1991,1]]},"DOI":"10.1093\/ajcn\/53.1.346s","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T15:37:36Z","timestamp":1515166656000},"page":"346S-351S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["A possible role for vitamins C and E in cataract prevention"],"prefix":"10.1016","volume":"53","author":[{"given":"JM","family":"Robertson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AP","family":"Donner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JR","family":"Trevithick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/53.1.346S_bib1","first-page":"640","article-title":"Reversal of galactose cataract with sorbinol in rats.","volume":"24","author":"Hu","year":"1983","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1093\/ajcn\/53.1.346S_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/0014-4835(83)90106-9","article-title":"Inhibition of galactose-induced alterations in ocular lens with sorbinol.","volume":"36","author":"Unakar","year":"1983","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2337\/diab.34.1.15","article-title":"Reversal of diabetic cataract by sorbinol, an aldose reductase inhibitor.","volume":"34","author":"Beyers-Mears","year":"1985","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/53.1.346S_bib4","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000138103","article-title":"Reversal of stage-I sugar cataract by sorbinol, an aldose reductase inhibitor.","volume":"31","author":"Beyer-Mears","year":"1985","journal-title":"Pharmacology"},{"key":"10.1093\/ajcn\/53.1.346S_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3181\/00379727-178-42048","article-title":"Prevention of cataract development in severely galactosemic rats by the aldose reductase inhibitor, tolrestat.","volume":"178","author":"Simard-Duquesne","year":"1985","journal-title":"Proc Soc Exp Biol Med"},{"issue":"4 suppl 1","key":"10.1093\/ajcn\/53.1.346S_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0026-0495(86)90178-2","article-title":"Introduction: evidence for the role of the polyol pathway in the pathophysiology of diabetic complications.","volume":"35","author":"Beyer","year":"1986","journal-title":"Metabolism"},{"issue":"4 suppl 1","key":"10.1093\/ajcn\/53.1.346S_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0026-0495(86)90181-2","article-title":"The effect of aldose reductase and its inhibition on sugar cataract formation.","volume":"35","author":"Kador","year":"1986","journal-title":"Metabolism"},{"issue":"4 suppl 1","key":"10.1093\/ajcn\/53.1.346S_bib8","first-page":"4","article-title":"Effects of the aldose reductase inhibitor sorbinol on the isolated cultured rat lens.","volume":"35","author":"Yeh","year":"1986","journal-title":"Metabolism"},{"key":"10.1093\/ajcn\/53.1.346S_bib9","first-page":"343","article-title":"Inhibition of aldose reductase by flavonoids; possible attenuation of diabetic complications.","volume":"213","author":"Varma","year":"1986","journal-title":"Prog Clin Biol Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0014-4835(81)80025-5","article-title":"Photodynamic effects of rose bengal or riboflavin on carrier-mediated transport systems in rat lens.","volume":"32","author":"Jemigan","year":"1981","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/02713688408997188","article-title":"Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract.","volume":"3","author":"Bhuyan","year":"1984","journal-title":"Curr Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/02713688408997186","article-title":"Oxidative stress on lens and cataract formation: role of light and oxygen.","volume":"3","author":"Varma","year":"1984","journal-title":"Curr Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0014-4835(86)80015-X","article-title":"Nuclear cataract: oxidative damage to the lens.","volume":"43","author":"Lohmann","year":"1986","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000265448","article-title":"Effects of dexamethasone phosphate on the formation of ester forms of riboflavin in the lens.","volume":"18","author":"Ono","year":"1986","journal-title":"Ophthalmic Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000265189","article-title":"Photoperoxidation in lens and cataract formation: preventive role of superoxide dismutase, catalase and vitamin C.","volume":"14","author":"Varma","year":"1982","journal-title":"Ophthalmic Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib16","first-page":"283","article-title":"Ascorbate delays ultraviolet-induced, age-related damage to lens protease and the effect of maturation and aging on the function of the ubiquitin-lens protein conjugation apparatus.","author":"Taylor","year":"1987","journal-title":"Proteases Biol Control Biotechnol"},{"key":"10.1093\/ajcn\/53.1.346S_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0047-6374(87)90052-2","article-title":"Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: ascorbate can delay this damage.","volume":"41","author":"Blondin","year":"1987","journal-title":"Meeh Ageing Dev"},{"key":"10.1093\/ajcn\/53.1.346S_bib18","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0014-4835(79)90025-3","article-title":"Cortical cataract formation prevented by vitamin E and glutathione.","volume":"29","author":"Creighton","year":"1979","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-4835(81)80038-3","article-title":"Effects of vitamin E on cortical cataractogenesis induced by elevated temperature in intact rat lenses in medium 199.","volume":"32","author":"Stewart-DeHaan","year":"1981","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1751-1097.1982.tb09481.x","article-title":"Photoperoxidation of lens lipids: prevention by vitamin E.","volume":"36","author":"Varma","year":"1982","journal-title":"Photochem Photobiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0014-4835(83)90102-1","article-title":"Radiation cataract formation diminished by vitamin E in rat lenses in vitro.","volume":"36","author":"Ross","year":"1983","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-4835(83)90150-1","article-title":"Modelling cortical cataractogenesis V. Steroid cataracts induced by solumedrol partially prevented by vitamin E in vitro.","volume":"37","author":"Creighton","year":"1983","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-4835(85)90006-5","article-title":"Modelling cortical cataractogenesis VII. Effects of vitamin E treatment on galactose-induced cataracts.","volume":"40","author":"Creighton","year":"1985","journal-title":"Exp Eye Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib24","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jps.2600671045","article-title":"Use of guinea pigs as models to study galactose-induced cataract formation.","volume":"67","author":"Kosegarten","year":"1978","journal-title":"J Pharm Sci"},{"key":"10.1093\/ajcn\/53.1.346S_bib25","first-page":"9","article-title":"Prevention of eye lens protein damage by dietary vitamin C.","volume":"27","author":"Blondin","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1093\/ajcn\/53.1.346S_bib26","first-page":"61","article-title":"Modelling cortical cataractogenesis: 3. In vivo effects of vitamin E on cataractogenesis in diabetic rats.","volume":"17","author":"Ross","year":"1982","journal-title":"Can J Ophthalmol"},{"key":"10.1093\/ajcn\/53.1.346S_bib27","first-page":"620","article-title":"Prevention of experimental cataract by alpha-tocopherol.","volume":"22","author":"Gupta","year":"1984","journal-title":"Indian J Exp Biol"},{"key":"10.1093\/ajcn\/53.1.346S_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000265348","article-title":"Changes of some biochemical parameters of the lens in galactose-treated weaned rats with and without vitamin E therapy.","volume":"17","author":"Libondi","year":"1985","journal-title":"Ophthalmic Res"},{"key":"10.1093\/ajcn\/53.1.346S_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1749-6632.1982.tb31242.x","article-title":"The role of vitamin E therapy of cataract in animals.","volume":"393","author":"Bhuyan","year":"1982","journal-title":"Ann NY Acad Sci"},{"key":"10.1093\/ajcn\/53.1.346S_bib30","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1001\/archopht.1988.01060130363022","article-title":"Antioxidant status in persons with and without senile cataract.","volume":"106","author":"Jacques","year":"1988","journal-title":"Arch Ophthalmol"},{"key":"10.1093\/ajcn\/53.1.346S_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/oxfordjournals.aje.a112429","article-title":"The Framingham Eye Study. II. Association of ophthalmic pathology with single variables previously measured in the Framingham Heart Study.","volume":"106","author":"Kahn","year":"1977","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/oxfordjournals.aje.a113625","article-title":"The epidemiology of senile cataracts: a review.","volume":"118","author":"Leske","year":"1983","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/oxfordjournals.aje.a113631","article-title":"Epidemiologic associations with cataract in the 1971-72 National Health and Nutrition Examination Survey.","volume":"118","author":"Hiller","year":"1983","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib34","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/oxfordjournals.aje.a114481","article-title":"Epidemiologic associations with nuclear, cortical, and posterior subcapsular cataracts.","volume":"124","author":"Hiller","year":"1986","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib35","series-title":"Case-control studies: design, conduct, analysis.","first-page":"207","author":"Schlesselman","year":"1982"},{"key":"10.1093\/ajcn\/53.1.346S_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/ije\/7.4.367","article-title":"Analytical methods in matched pair epidemiological studies.","volume":"7","author":"Posner","year":"1978","journal-title":"Int J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib37","series-title":"Fundamental research statistics for the behavioral sciences.","first-page":"170","author":"Roscoe","year":"1969"},{"key":"10.1093\/ajcn\/53.1.346S_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.aje.a112428","article-title":"The Framingham Eye Study. I. Outline and major prevalence findings.","volume":"106","author":"Kahn","year":"1977","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/53.1.346S_bib39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/oxfordjournals.aje.a113628","article-title":"Incidence estimates for lens changes, macular changes, open-angle glaucoma and diabetic retinopathy.","volume":"118","author":"Podgor","year":"1983","journal-title":"Am J Epidemiol"},{"issue":"suppl","key":"10.1093\/ajcn\/53.1.346S_bib40","first-page":"335","article-title":"The Framingham Eye Study Monograph.","volume":"24","author":"Leibowitz","year":"1980","journal-title":"Surv Opthalmol"},{"key":"10.1093\/ajcn\/53.1.346S_bib41","series-title":"Population projections for Canada and the Provinces, 1972-2001.","year":"1974"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523170973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523170973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/53\/1\/346S\/24063430\/346s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T04:08:48Z","timestamp":1686283728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523170973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["S0002916523170973"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/53.1.346s","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1991,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A possible role for vitamins C and E in cataract prevention","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/53.1.346S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1991 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}