{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:54:54Z","timestamp":1791287694820,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":9702,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1996,8]]},"DOI":"10.1093\/ajcn\/64.2.232","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T15:29:59Z","timestamp":1515079799000},"page":"232-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":214,"title":["Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance"],"prefix":"10.1016","volume":"64","author":[{"given":"SR","family":"Hertzler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DA","family":"Savaiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/64.2.232_bib1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/ajcn\/25.1.114","article-title":"Lactase deficiency in Indians.","volume":"25","author":"Reddy","year":"1972","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1651-2227.1973.tb17080.x","article-title":"Lactose malabsorption in Ethiopian children.","volume":"62","author":"Habte","year":"1973","journal-title":"Acta Paediatr Scand"},{"key":"10.1093\/ajcn\/64.2.232_bib3","doi-asserted-by":"crossref","first-page":"1083S","DOI":"10.1093\/ajcn\/48.4.1142","article-title":"The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance.","volume":"48","author":"Scrimshaw","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0016-5085(72)80080-5","article-title":"Lactase in man: a nonadaptable enzyme.","volume":"62","author":"Gilat","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/64.2.232_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI110079","article-title":"Role of pH in production of hydrogen from carbohydrates by colonic bacterial flora.","volume":"67","author":"Perman","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/64.2.232_bib6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1172\/JCI111738","article-title":"Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study).","volume":"75","author":"Florent","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/64.2.232_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/ajcn\/58.3.369","article-title":"Can diarrhea induced by lactulose be reduced by prolonged ingestion of lactulose?","volume":"58","author":"Flouri\u00e9","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib8","first-page":"A197","article-title":"Does a prolonged lactose ingestion induce clinical and colonic metabolism adaptations in lactose intolerant subjects?","volume":"102","author":"Arrigoni","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/64.2.232_bib9","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/ajcn\/58.6.879","article-title":"Adaptation of lactose maldigesters to continued milk intakes.","volume":"58","author":"Johnson","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib10","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/0016-5085(93)90145-3","article-title":"Detection of malabsorption of low doses of carbohydrate: accuracy of various breath H2 criteria.","volume":"105","author":"Strocchi","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/64.2.232_bib11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/ajcn\/59.5.1021","article-title":"Lactose digestion and tolerance in adult and elderly Asian-Americans.","volume":"59","author":"Suarez","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib12","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/ajcn\/53.5.1253","article-title":"Lactose digestion from yogurt: influence of a meal and additional lactose.","volume":"53","author":"Martini","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib13","series-title":"Fundamentals of general, organic, and biological chemistry.","article-title":"Fundamentals of general, organic, and biological chemistry.","author":"Holum","year":"1982"},{"key":"10.1093\/ajcn\/64.2.232_bib14","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1007\/BF01297079","article-title":"Comparative effects of exogenous lactase (\u03b2-galactosidase) preparations on in vivo lactose digestion.","volume":"38","author":"Lin","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1093\/ajcn\/64.2.232_bib15","series-title":"SYSTAT for the Macintosh, version 5.2.","year":"1992"},{"key":"10.1093\/ajcn\/64.2.232_bib16","series-title":"Design and analysis of experiments.","article-title":"Design and analysis of experiments.","author":"Montgomery","year":"1991"},{"key":"10.1093\/ajcn\/64.2.232_bib17","series-title":"Practical nonparametric statistics.","article-title":"Practical nonparametric statistics.","author":"Conover","year":"1980"},{"key":"10.1093\/ajcn\/64.2.232_bib18","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0016-5085(19)33008-2","article-title":"Intolerance of small amounts of lactose by individuals with low lactase levels.","volume":"65","author":"Bedine","year":"1973","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/64.2.232_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF01072273","article-title":"Individual sensitivity to lactose in lactose malabsorption.","volume":"22","author":"Gudmand-H\u00f8yer","year":"1977","journal-title":"Dig Dis"},{"key":"10.1093\/ajcn\/64.2.232_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/ajcn\/47.1.57","article-title":"Reduced intolerance symptoms from lactose consumed during a meal.","volume":"47","author":"Martini","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/64.2.232_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199507063330101","article-title":"A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance.","volume":"333","author":"Suarez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/64.2.232_bib22","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI114267","article-title":"Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose.","volume":"84","author":"Hammer","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/64.2.232_bib23","series-title":"Milk intolerances and rejection.","first-page":"22","article-title":"Bacterial adaptation to lactase deficiency.","author":"Hill","year":"1983"},{"key":"10.1093\/ajcn\/64.2.232_bib24","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/gut.32.6.665","article-title":"Investigation of normal flatus production in healthy volunteers.","volume":"32","author":"Tomlin","year":"1991","journal-title":"Gut"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523173801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523173801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/64\/2\/232\/23158105\/232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T04:21:35Z","timestamp":1686284495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523173801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["S0002916523173801"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/64.2.232","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1996,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/64.2.232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}