{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:27:41Z","timestamp":1791073661683,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":8921,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1093\/ajcn\/68.4.859","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T14:29:08Z","timestamp":1515162548000},"page":"859-865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"title":["Dietary protein affects intestinal calcium absorption"],"prefix":"10.1016","volume":"68","author":[{"given":"Jane E","family":"Kerstetter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly O","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl L","family":"Insogna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/68.4.859_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/jn\/110.2.305","article-title":"Studies on the mechanism of protein-induced hypercalciuria in older men and women","volume":"110","author":"Schuette","year":"1980","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/jn\/109.8.1399","article-title":"Effect of level of protein intake on calcium metabolism and on parathyroid and renal function in the adult human male","volume":"109","author":"Kim","year":"1979","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/geronj\/36.1.14","article-title":"Acute effects of dietary protein on calcium metabolism in patients with osteoporosis","volume":"36","author":"Licata","year":"1981","journal-title":"J Gerontol"},{"key":"10.1093\/ajcn\/68.4.859_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3177\/jnsv.36.105","article-title":"Urinary calcium and calcium balance in young women affected by high protein diet of soy protein isolate and adding sulfur-containing amino acids and\/or potassium","volume":"36","author":"Kaneko","year":"1990","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1093\/ajcn\/68.4.859_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0271-5317(05)80304-5","article-title":"Effects of a high protein intake from common foods on calcium metabolism in a cohort of postmenopausal women","volume":"11","author":"Draper","year":"1991","journal-title":"Nutr Res"},{"key":"10.1093\/ajcn\/68.4.859_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1079\/BJN19970070","article-title":"Calcium excretion, apparent calcium absorption and calcium balance in young and elderly subjects: influence of protein intake","volume":"77","author":"Pannemans","year":"1997","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib7","first-page":"167","article-title":"Protein intake and calcium homeostasis","volume":"9","author":"Kerstetter","year":"1994","journal-title":"Adv Nutr Res"},{"key":"10.1093\/ajcn\/68.4.859_bib8","first-page":"F613","article-title":"Human response to a meat meal","volume":"250","author":"Hostetter","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1093\/ajcn\/68.4.859_bib9","first-page":"S325","article-title":"Increasing dietary protein increases markers of bone turnover in young women","volume":"11","author":"Kerstetter","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1093\/ajcn\/68.4.859_bib10","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/jn\/125.11.2814","article-title":"Short-term changes in calcium but not protein intake alter the rate of bone resorption in healthy subjects as assessed by urinary pyridinium cross-link excretion","volume":"125","author":"Shapses","year":"1995","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/oxfordjournals.aje.a008767","article-title":"Protein consumption and bone fractures in women","volume":"143","author":"Feskanich","year":"1996","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/68.4.859_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF02509379","article-title":"Dietary protein intake and bone mass in women","volume":"58","author":"Cooper","year":"1996","journal-title":"Calcif Tissue Int"},{"key":"10.1093\/ajcn\/68.4.859_bib13","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/ajcn\/66.5.1188","article-title":"Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet","volume":"66","author":"Kerstetter","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/jn\/112.2.338","article-title":"Effects on Ca and P metabolism in humans by adding meat, meat plus milk, or purified proteins plus Ca and P to a low protein diet","volume":"112","author":"Schuette","year":"1982","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib15","first-page":"46","article-title":"Effects of nitrogen, phosphorus, and caffeine on calcium balance in women","volume":"99","author":"Heaney","year":"1982","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/68.4.859_bib16","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/ajcn\/31.12.2167","article-title":"Effect of a high protein (meat) intake on calcium metabolism in man","volume":"31","author":"Spencer","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/ajcn\/37.6.924","article-title":"Further studies of the effect of a high protein diet as meat on calcium metabolism","volume":"37","author":"Spencer","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000415199","article-title":"Phytate in foods","volume":"52","author":"Harland","year":"1987","journal-title":"World Rev Nutr Diet"},{"key":"10.1093\/ajcn\/68.4.859_bib19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1139\/y90-147","article-title":"Recent studies of human calcium metabolism using stable isotopic tracers","volume":"68","author":"Yergey","year":"1990","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1093\/ajcn\/68.4.859_bib20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1203\/00006450-199310000-00014","article-title":"Pubertal changes in calcium kinetics in girls assessed using 42Ca","volume":"34","author":"Abrams","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1093\/ajcn\/68.4.859_bib21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1210\/jcem-54-5-1017","article-title":"Radioimmunoassay for the middle region of human parathyroid hormone using an homologous antiserum with a carboxy-terminal fragment of bovine parathyroid hormone as radioligand","volume":"54","author":"Mallette","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/ajcn\/68.4.859_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/jcem-58-1-91","article-title":"A microassay for 1,25 (OH)2 D not requiring high performance liquid chromatography","volume":"58","author":"Reinhardt","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1093\/ajcn\/68.4.859_bib23","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1056\/NEJM198510313131805","article-title":"Sensitivity of the parathryoid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism","volume":"313","author":"Insogna","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/68.4.859_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000181623","article-title":"Nephrogenous cyclic AMP as a parathyroid function test","volume":"23","author":"Broadus","year":"1979","journal-title":"Nephron"},{"key":"10.1093\/ajcn\/68.4.859_bib25","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jbmr.5650040404","article-title":"Calcium absorption in women: relationships to calcium intake, estrogen status, and age","volume":"4","author":"Heaney","year":"1989","journal-title":"J Bone Miner Res"},{"key":"10.1093\/ajcn\/68.4.859_bib26","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/jbmr.5650091016","article-title":"Determinants of endogenous fecal calcium in healthy women","volume":"9","author":"Heaney","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1093\/ajcn\/68.4.859_bib27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/ajcn\/46.4.699","article-title":"Effects of glucose and glucose polymers on calcium absorption in healthy subjects","volume":"46","author":"Wood","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib28","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/ajcn\/47.4.707","article-title":"Calcium absorbability from spinach","volume":"47","author":"Heaney","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib29","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/jbmr.5650051107","article-title":"Influence of calcium load on absorption fraction","volume":"5","author":"Heaney","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1093\/ajcn\/68.4.859_bib30","first-page":"822","article-title":"A double isotope method for measurement of intestinal absorption of calcium in man","volume":"66","author":"DeGrazia","year":"1965","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/68.4.859_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/ajcn\/56.2.314","article-title":"Effects of dietary protein deficiency on mineral metabolism and bone mineral density","volume":"56","author":"Orwoll","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib32","series-title":"Protein nutrition and mineral absorption","first-page":"77","article-title":"Calcium, magnesium and phosphorus absorption, nutritional status and effect of proteins","author":"Wapner","year":"1990"},{"key":"10.1093\/ajcn\/68.4.859_bib33","series-title":"Mineral absorption in the monogastric gastrointestinal tract Adv Exp Med Biol","first-page":"95","article-title":"Protein digestion and the absorption of mineral elements","author":"Wapner","year":"1989"},{"key":"10.1093\/ajcn\/68.4.859_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0271-5317(05)80636-0","article-title":"Intestinal adaptation to dietary calcium restriction in rats fed high protein diets","volume":"11","author":"Wood","year":"1991","journal-title":"Nutr Res"},{"key":"10.1093\/ajcn\/68.4.859_bib35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/jn\/111.2.244","article-title":"Long-term effects of level of protein intake on calcium metabolism in young adult women","volume":"111","author":"Hegsted","year":"1981","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib36","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/ajcn\/51.4.656","article-title":"Calcium absorption from kale","volume":"51","author":"Heaney","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib37","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/jn\/121.11.1769","article-title":"Human calcium absorption from whole-wheat products","volume":"121","author":"Weaver","year":"1991","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/07315724.1987.10720182","article-title":"Effect of wheat bran on bowel function and fecal calcium in older adults","volume":"6","author":"Balasubramanian","year":"1987","journal-title":"J Am Coll Nutr"},{"key":"10.1093\/ajcn\/68.4.859_bib39","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/jf00118a045","article-title":"Calcium binding to phytic acid","volume":"31","author":"Graf","year":"1983","journal-title":"J Agric Food Chem"},{"key":"10.1093\/ajcn\/68.4.859_bib40","series-title":"Modern nutrition in health and disease","first-page":"144","article-title":"Calcium and phosphorus","author":"Allen","year":"1994"},{"key":"10.1093\/ajcn\/68.4.859_bib41","series-title":"Recommended dietary allowances","year":"1989"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523006949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523006949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/68\/4\/859\/23190012\/859.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:13:45Z","timestamp":1751195625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523006949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["S0002916523006949"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/68.4.859","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary protein affects intestinal calcium absorption","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/68.4.859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 American Society for Clinical Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}