{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:52:20Z","timestamp":1790902340256,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":8276,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1093\/ajcn\/72.1.181","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T20:32:57Z","timestamp":1519158777000},"page":"181-189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":126,"title":["Plasma antioxidant status after high-dose chemotherapy: a randomized trial of parenteral nutrition in bone marrow transplantation patients"],"prefix":"10.1016","volume":"72","author":[{"given":"Carolyn R","family":"Jonas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B","family":"Puckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaina E","family":"Szeszycki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen F","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste E","family":"Furr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleve","family":"Tyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/72.1.181_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/011542659400900391","article-title":"Nutrition support in patients with cancer: what do the data really show?","volume":"9","author":"Klein","year":"1994","journal-title":"Nutr Clin Pract"},{"key":"10.1093\/ajcn\/72.1.181_bib2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/00007890-198743060-00012","article-title":"Positive effect of prophylactic total parenteral nutrition on long-term outcome of bone marrow transplantation","volume":"43","author":"Weisdorf","year":"1987","journal-title":"Transplantation"},{"key":"10.1093\/ajcn\/72.1.181_bib3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.7326\/0003-4819-116-10-821","article-title":"Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition following bone marrow transplantation: a randomized, double-blind, controlled study","volume":"116","author":"Ziegler","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/72.1.181_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mpo.2950110213","article-title":"Effect of total parenteral nutrition (PN) on chemotherapy and survival of acute leukemia in childhood","volume":"11","author":"Hays","year":"1983","journal-title":"Med Pediatr Oncol"},{"key":"10.1093\/ajcn\/72.1.181_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00005176-198401000-00020","article-title":"Total parenteral nutrition in bone marrow transplantation: a clinical evaluation","volume":"3","author":"Weisdorf","year":"1984","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib6","first-page":"3309","article-title":"Nutritional support of bone marrow transplantation recipients: a prospective, randomized clinical trial comparing total parenteral nutrition to an enteral feeding program","volume":"47","author":"Szeluga","year":"1987","journal-title":"Cancer Res"},{"key":"10.1093\/ajcn\/72.1.181_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0305-7372(97)90012-8","article-title":"Free radicals and antioxidants in chemotherapy-induced toxicity","volume":"23","author":"Weijl","year":"1997","journal-title":"Cancer Treat Rev"},{"key":"10.1093\/ajcn\/72.1.181_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0891-5849(90)90139-A","article-title":"Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer","volume":"8","author":"Sangeetha","year":"1990","journal-title":"Free Radic Biol Med"},{"key":"10.1093\/ajcn\/72.1.181_bib9","first-page":"757","article-title":"Deteriorating free radical-trapping capacity and antioxidant status in plasma during bone marrow transplantion","volume":"15","author":"Durken","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1093\/ajcn\/72.1.181_bib10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/BF00686635","article-title":"Depletion of total cysteine, glutathione, and homocysteine in plasma by ifosfamide\/mesna therapy","volume":"35","author":"Lauterburg","year":"1994","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1093\/ajcn\/72.1.181_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3109\/10715768909087946","article-title":"Decreased essential antioxidants and increased lipid hydroperoxides following high-dose radiochemotherapy","volume":"7","author":"Clemens","year":"1989","journal-title":"Free Radic Res Commun"},{"key":"10.1093\/ajcn\/72.1.181_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/BF00689585","article-title":"Effect of etoposide (VP16\u2013213) on lipid peroxidation and antioxidant status in a high-dose radiochemotherapy regimen","volume":"25","author":"Ladner","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1093\/ajcn\/72.1.181_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF02790109","article-title":"Lipoperoxides as an index of free radical activity in bone marrow transplant recipients","volume":"47","author":"Hunnisett","year":"1995","journal-title":"Biol Trace Miner"},{"key":"10.1093\/ajcn\/72.1.181_bib14","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0891-5849(95)02187-6","article-title":"5-Hydroxymethyluracil excretion, plasma TBARS and plasma antioxidant vitamins in adriamycin-treated patients","volume":"20","author":"Faure","year":"1996","journal-title":"Free Radic Biol Med"},{"key":"10.1093\/ajcn\/72.1.181_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/ajcn\/51.2.216","article-title":"Plasma vitamin E and \u03b2-carotene concentrations during radiochemotherapy preceding bone marrow transplantation","volume":"51","author":"Clemens","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0163-7258(91)90076-X","article-title":"Glutathione deficiency produced by inhibition of its synthesis and its reversal: applications in research and therapy","volume":"51","author":"Meister","year":"1991","journal-title":"Pharmacol Ther"},{"key":"10.1093\/ajcn\/72.1.181_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2008-1040727","article-title":"Overview of alkylation and peroxidation mechanisms in acute lethal heptocellular injury by chemically reactive metabolites","volume":"1","author":"Mitchell","year":"1981","journal-title":"Semin Liver Dis"},{"key":"10.1093\/ajcn\/72.1.181_bib18","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/00001813-199609000-00012","article-title":"Effects of diallyl sulfide and diallyl disulfide on cisplatin-induced changes in glutathione and glutathione-S-transferase activity","volume":"7","author":"Dwivedi","year":"1996","journal-title":"Anticancer Drugs"},{"key":"10.1093\/ajcn\/72.1.181_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00225878","article-title":"Effect of radiotherapy and chemotherapy on circulating antioxidant system of human uterine cervical carcinoma","volume":"158","author":"Bhuvarahamurthy","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"10.1093\/ajcn\/72.1.181_bib20","article-title":"On the antioxidant effects of ascorbic acid and glutathione","volume":"44","author":"Meister","year":"1905","journal-title":"Biochem Pharmacol"},{"key":"10.1093\/ajcn\/72.1.181_bib21","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1161\/01.ATV.18.10.1662","article-title":"Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins","volume":"18","author":"Siow","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1093\/ajcn\/72.1.181_bib22","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/ajcn\/68.4.888","article-title":"Lipid peroxidation and antioxidant status in adults receiving lipid-based home parenteral nutrition","volume":"68","author":"Pironi","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib23","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/ajcn\/48.6.1394","article-title":"Increased lipid peroxidation after lipid infusion as measured by breath pentane output","volume":"48","author":"Van Gossum","year":"1988","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1203\/00006450-199101000-00011","article-title":"Generation of free radicals in lipid emulsion used in parenteral nutrition","volume":"29","author":"Pitkanen","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1093\/ajcn\/72.1.181_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0022-3476(95)70412-4","article-title":"Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: potential toxicity of routine parenteral feeding","volume":"126","author":"Neuzil","year":"1995","journal-title":"J Pediatr"},{"key":"10.1093\/ajcn\/72.1.181_bib26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1042\/cs0850709","article-title":"Hydrogen peroxide generation in a model paediatric parenteral amino acid solution","volume":"85","author":"Brawley","year":"1993","journal-title":"Clin Sci"},{"key":"10.1093\/ajcn\/72.1.181_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/0148607185009002139","article-title":"Energy requirements of parenterally fed bone marrow transplant recipients","volume":"9","author":"Szeluga","year":"1985","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0009-8981(98)00089-8","article-title":"Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC.","volume":"275","author":"Jones","year":"1998","journal-title":"Clin Chem Acta"},{"key":"10.1093\/ajcn\/72.1.181_bib29","series-title":"Oxidation-reduction potentials of organic systems.","first-page":"248","article-title":"The standard hydrogen half-cell and the standardization of oxidation-reduction potentials and pH numbers","author":"Clarke","year":"1960"},{"key":"10.1093\/ajcn\/72.1.181_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/201185a0","article-title":"Reduction potential of glutathione","volume":"201","author":"Rost","year":"1964","journal-title":"Nature"},{"key":"10.1093\/ajcn\/72.1.181_bib31","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/ajcn\/32.10.2143","article-title":"Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography","volume":"32","author":"Bieri","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0003-2697(87)90206-5","article-title":"A highly sensitive high-performance liquid chromatography method for the estimation of ascorbic and dehydoascorbic acid in tissues, biological fluids, and foods","volume":"165","author":"Behrens","year":"1987","journal-title":"Analyt Biochem"},{"key":"10.1093\/ajcn\/72.1.181_bib33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/clinchem\/28.2.311","article-title":"Determination of selenium concentration and glutathione peroxidase activity in plasma and erythrocytes","volume":"28","author":"Pleban","year":"1982","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/72.1.181_bib34","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/clinchem\/27.8.1438","article-title":"Automated determination of copper in undiluted serum by atomic absorption spectroscopy","volume":"27","author":"Weinstock","year":"1981","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/72.1.181_bib35","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0891-5849(97)00286-4","article-title":"Glutathione in human plasma: decline in association with aging, age-related macular degeneration and diabetes","volume":"24","author":"Samiec","year":"1998","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"10.1093\/ajcn\/72.1.181_bib36","first-page":"62","article-title":"Modulation of glutathione depletion and lipid peroxidation by WR-77913 and 2-mercaptopropionlyglycine in cyclophosphamide chemotherapy","volume":"32","author":"Bhanumathi","year":"1994","journal-title":"Indian J Exp Biol"},{"key":"10.1093\/ajcn\/72.1.181_bib37","first-page":"114","article-title":"Induction of hepatic veno-occlusive disease in dogs","volume":"126","author":"Shulman","year":"1987","journal-title":"Am J Pathol"},{"key":"10.1093\/ajcn\/72.1.181_bib38","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0891-5849(96)00554-0","article-title":"Blood glutathione as an index of radiation-induced oxidative stress in mice and humans","volume":"22","author":"Navarro","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1093\/ajcn\/72.1.181_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/08860229309046144","article-title":"Role of glutathione for cisplatin nephrotoxicity in young and adult rats","volume":"15","author":"Appenroth","year":"1993","journal-title":"Ren Fail"},{"key":"10.1093\/ajcn\/72.1.181_bib40","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1096\/fasebj.4.14.2227215","article-title":"Protection against cisplatin toxicity by administration of glutathione ester","volume":"4","author":"Anderson","year":"1990","journal-title":"FASEB J"},{"key":"10.1093\/ajcn\/72.1.181_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1753-4887.1984.tb02277.x","article-title":"New aspects of glutathione biochemistry and transport\u2014selective alteration of glutathione metabolism","volume":"42","author":"Meister","year":"1984","journal-title":"Nutr Rev"},{"key":"10.1093\/ajcn\/72.1.181_bib42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/o79-029","article-title":"Ammonia production and glutamine incorporation into GSH in the functioning rat kidney","volume":"57","author":"Welbourne","year":"1979","journal-title":"Can J Biochem"},{"key":"10.1093\/ajcn\/72.1.181_bib43","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00000658-199202000-00004","article-title":"Glutamine preserves liver glutathione after lethal hepatic injury","volume":"215","author":"Hong","year":"1992","journal-title":"Ann Surg"},{"key":"10.1093\/ajcn\/72.1.181_bib44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/jsre.1994.1054","article-title":"Glutamine serves gut glutathione levels during intestinal ischemia\/reperfusion","volume":"54","author":"Harward","year":"1994","journal-title":"J Surg Res"},{"key":"10.1093\/ajcn\/72.1.181_bib45","series-title":"Glutathione centennial: molecular perspectives and clinical applications.","first-page":"103","article-title":"Structure and catalytic mechanism of glutathione peroxidase","author":"Flohe","year":"1989"},{"key":"10.1093\/ajcn\/72.1.181_bib46","first-page":"4766","article-title":"Adriamycin-induced free radical formation in the perfused rat heart. Implications for cardiotoxicity","volume":"48","author":"Rajagopalan","year":"1988","journal-title":"Cancer Res"},{"key":"10.1093\/ajcn\/72.1.181_bib47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/0148607179003004258","article-title":"A statement by the Nutrition Advisory Group. American Medical Association Department of Foods and Nutrition, 1975.","volume":"3","year":"1979","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-4274(92)90110-6","article-title":"Glutathione and tissue amino acid responses to light-exposed parenteral nutrients","volume":"63","author":"Bhatia","year":"1992","journal-title":"Toxicol Lett"},{"key":"10.1093\/ajcn\/72.1.181_bib49","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/jn\/121.12.1969","article-title":"Glutathione blood levels and other oxidant defense indices in men fed diets low in vitamin C.","volume":"121","author":"Henning","year":"1991","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/72.1.181_bib50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0891-5849(90)90076-U","article-title":"The physiological role of zinc as an antioxidant","volume":"8","author":"Bray","year":"1990","journal-title":"Free Radic Biol Med"},{"key":"10.1093\/ajcn\/72.1.181_bib51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/011542659501000116","article-title":"Use of vitamin E and glutamine in the successful treatment of severe veno-occlusive disease following bone marrow transplantation","volume":"10","author":"Nattakom","year":"1995","journal-title":"Nutr Clin Pract"},{"key":"10.1093\/ajcn\/72.1.181_bib52","first-page":"771","article-title":"Supplementation with antioxidants prior to bone marrow transplantation","volume":"109","author":"Clemens","year":"1997","journal-title":"Wien Klin Wochenschr"},{"key":"10.1093\/ajcn\/72.1.181_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1536\/ihj.37.353","article-title":"Cardioprotection in patients undergoing chemo- and\/or radiotherapy for neoplastic disease. A pilot study","volume":"37","author":"Wagdi","year":"1996","journal-title":"Jpn Heart J"},{"key":"10.1093\/ajcn\/72.1.181_bib54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1200\/JCO.1995.13.1.26","article-title":"Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial","volume":"13","author":"Cascinu","year":"1995","journal-title":"J Clin Oncol"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523066819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523066819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/72\/1\/181\/23961096\/181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:42:17Z","timestamp":1686278537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523066819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0002916523066819"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/72.1.181","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma antioxidant status after high-dose chemotherapy: a randomized trial of parenteral nutrition in bone marrow transplantation patients","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/72.1.181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}