{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:11:22Z","timestamp":1780078282581,"version":"3.54.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":8033,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1093\/ajcn\/73.3.582","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T20:36:48Z","timestamp":1519159008000},"page":"582-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["High prevalence of lactose absorbers in Northern Sardinian patients with type 1 and type 2 diabetes mellitus"],"prefix":"10.1016","volume":"73","author":[{"given":"Gian Franco","family":"Meloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Pacifico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Tomasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Ogana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Marinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Meloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/73.3.582_bib1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF01212169","article-title":"Increase of intestinal brush border hydrolases in mucosa of streptozotocin-diabetic rats","volume":"8","author":"Caspary","year":"1972","journal-title":"Diabetologica"},{"key":"10.1093\/ajcn\/73.3.582_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF01391373","article-title":"Structural features of the rat small intestinal microvillous membrane in acute experimental diabetes","volume":"27","author":"Madara","year":"1982","journal-title":"Dig Dis Sci"},{"key":"10.1093\/ajcn\/73.3.582_bib3","first-page":"838","article-title":"Jejunal sucrase activity in diabetic rats","volume":"77","author":"Olsen","year":"1972","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/73.3.582_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1172\/JCI108755","article-title":"The intestinal brush border membrane in diabetes. Studies of sucrase-isomaltase metabolism in rats with streptozotocin diabetes","volume":"60","author":"Olsen","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/73.3.582_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3177\/jnsv.29.571","article-title":"Changes of the activity and content of sucrase-isomaltase complex in the intestinal mucosa during the development of streptozotocin-induced diabetes in rats","volume":"29","author":"Goda","year":"1983","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"10.1093\/ajcn\/73.3.582_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2337\/diab.32.3.265","article-title":"Elevated intestinal disaccharidase activity in the streptozotocin-diabetic rat is independent of enteral feeding","volume":"32","author":"Schedl","year":"1983","journal-title":"Diabetes"},{"key":"10.1093\/ajcn\/73.3.582_bib7","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj3290597","article-title":"Suppressive effect of insulin on the synthesis of sucrase-isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions","volume":"329","author":"Takenoshita","year":"1998","journal-title":"Biochem J"},{"key":"10.1093\/ajcn\/73.3.582_bib8","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/003655298750026778","article-title":"Effects of diabetes and hyperglycemia on disaccharidase activities in the rat","volume":"33","author":"Murakami","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/ajcn\/73.3.582_bib9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/ajcn\/28.6.621","article-title":"Increased disaccharidase activity in human diabetics","volume":"28","author":"Tandon","year":"1975","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/73.3.582_bib10","first-page":"841","article-title":"Brush border enzymes and malabsorption: elevated disaccharidases in chronic pancreatic insufficiency with diabetes mellitus","volume":"62","author":"Cerda","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/73.3.582_bib11","first-page":"74","article-title":"Consommation de lactose et activit\u00e9 lactasique: deux facteurs de risque de la cataracte s\u00e9nile et diab\u00e9tique. (Lactose consumption and lactase activity: two risk factors for senile and diabetic cataracts.)","volume":"1","author":"Birlouez-Aragon","year":"1990","journal-title":"Age Nutr"},{"key":"10.1093\/ajcn\/73.3.582_bib12","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1093\/ajcn\/73.3.582_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00008469-199706000-00006","article-title":"An assessment and reproducibility of food-frequency data provided by hospital controls","volume":"6","author":"D\u2019Avanzo","year":"1997","journal-title":"Eur J Cancer Prev"},{"key":"10.1093\/ajcn\/73.3.582_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/ajcn\/31.4.597","article-title":"Respiratory hydrogen excretion as a parameter for lactose malabsorption in children","volume":"31","author":"Fernandes","year":"1978","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/73.3.582_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(84)90409-4","article-title":"High frequency of lactose absorbers among adults with idiopathic senile and presenile cataract in a population with a high prevalence of primary adult lactose malabsorption","volume":"1","author":"Rinaldi","year":"1984","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/73.3.582_bib16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/ajcn\/39.5.752","article-title":"Breath hydrogen test for lactose absorption capacity: importance of timing of hydrogen excretion and of high fasting hydrogen concentration","volume":"39","author":"Flatz","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/73.3.582_bib17","series-title":"Statistical methods in cancer research. The analysis of case-control studies. Vol 1.","author":"Breslow","year":"1980"},{"key":"10.1093\/ajcn\/73.3.582_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/gut.39.2.210","article-title":"Lactose absorption in patients with glucose 6-phosphate dehydrogenase deficiency with and without favism","volume":"39","author":"Meloni","year":"1996","journal-title":"Gut"},{"key":"10.1093\/ajcn\/73.3.582_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/oxfordjournals.aje.a009978","article-title":"Lactose absorption in patients with ovarian cancer","volume":"150","author":"Meloni","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/73.3.582_bib20","series-title":"The metabolic and molecular bases of inherited disease.","first-page":"4451","article-title":"Small-intestinal disaccharidases","author":"Semenza","year":"1995"},{"key":"10.1093\/ajcn\/73.3.582_bib21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/oxfordjournals.epirev.a036197","article-title":"Risk factors for age-related cataracts","volume":"17","author":"Hodge","year":"1995","journal-title":"Epidemiol Rev"},{"key":"10.1093\/ajcn\/73.3.582_bib22","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/oxfordjournals.aje.a114481","article-title":"Epidemiologic association with nuclear cortical and posterior subcapsular cataract","volume":"124","author":"Hiller","year":"1986","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/73.3.582_bib23","series-title":"The metabolic and molecular bases of inherited disease.","first-page":"967","article-title":"Disorders of galactose metabolism","author":"Segal","year":"1995"},{"key":"10.1093\/ajcn\/73.3.582_bib24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000055554","article-title":"Cataract development in 12-month-old rats fed a 25% galactose diet and its relation to osmotic stress and oxidative damage","volume":"31","author":"Ohta","year":"1999","journal-title":"Ophthalmic Res"},{"key":"10.1093\/ajcn\/73.3.582_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/09286589409052365","article-title":"Risk factors for cortical, nuclear, posterior subcapsular and mixed cataract: a case-control study","volume":"1","author":"Miglior","year":"1994","journal-title":"Ophthalmic Epidemiol"},{"key":"10.1093\/ajcn\/73.3.582_bib26","first-page":"666","article-title":"Idiopathic presenile and senile cataract formation and changes in lactase activity","volume":"84","author":"Spinelli","year":"1987","journal-title":"Fortschr Ophthalmol"},{"key":"10.1093\/ajcn\/73.3.582_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/bjo.79.7.709","article-title":"High prevalence of lactose absorbers in patients with senile cataract from Northern Sardinia","volume":"70","author":"Meloni","year":"1995","journal-title":"Br J Ophthalmol"},{"key":"10.1093\/ajcn\/73.3.582_bib28","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/jn\/123.8.1370","article-title":"Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation","volume":"123","author":"Birlouez-Aragon","year":"1993","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/73.3.582_bib29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1139\/y99-021","article-title":"Effects of ethanol and diabetes on galactose oxidative metabolism and elimination in rats","volume":"77","author":"Mion","year":"1999","journal-title":"Can J Physiol Pharmacol"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523065504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523065504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/73\/3\/582\/23962982\/582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T22:49:11Z","timestamp":1751410151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523065504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["S0002916523065504"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/73.3.582","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High prevalence of lactose absorbers in Northern Sardinian patients with type 1 and type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/73.3.582","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}