{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:24:20Z","timestamp":1791012260515,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":7358,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1093\/ajcn\/77.1.189","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T03:22:05Z","timestamp":1516850525000},"page":"189-195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency"],"prefix":"10.1016","volume":"77","author":[{"given":"Kevin J","family":"Lenton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain T","family":"San\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Therriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 M","family":"Cantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Payette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Richard","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/77.1.189_bib1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0140-6736(00)04128-3","article-title":"Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study","volume":"357","author":"Khaw","year":"2001","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/77.1.189_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/ajcn\/72.1.139","article-title":"Vitamin C status and mortality in US adults","volume":"72","author":"Loria","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00001648-200007000-00013","article-title":"Diet and overall survival in a cohort of very elderly people","volume":"11","author":"Fortes","year":"2000","journal-title":"Epidemiology"},{"key":"10.1093\/ajcn\/77.1.189_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/01.HYP.37.2.261","article-title":"Ascorbic acid status and subsequent diastolic and systolic blood pressure","volume":"37","author":"Block","year":"2001","journal-title":"Hypertension"},{"key":"10.1093\/ajcn\/77.1.189_bib5","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/S0140-6736(99)04410-4","article-title":"Treatment of hypertension with ascorbic acid","volume":"354","author":"Duffy","year":"1999","journal-title":"Lancet"},{"issue":"suppl","key":"10.1093\/ajcn\/77.1.189_bib6","doi-asserted-by":"crossref","first-page":"1310S","DOI":"10.1093\/ajcn\/54.6.1310s","article-title":"Epidemiologic evidence regarding vitamin C and cancer","volume":"54","author":"Block","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib7","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ajcn\/69.6.1086","article-title":"Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans","volume":"69","author":"Carr","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib8","first-page":"17","article-title":"Vitamin C and vitamin E supplement use and colorectal cancer mortality in a large American Cancer Society cohort","volume":"10","author":"Jacobs","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/77.1.189_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0955-2863(98)00002-3","article-title":"Absorption, transport, and disposition of ascorbic acid in humans","volume":"9","author":"Rumsey","year":"1998","journal-title":"J Nutr Biochem"},{"key":"10.1093\/ajcn\/77.1.189_bib10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/ajcn\/71.5.1194","article-title":"Direct correlation of glutathione and ascorbate and their dependence on age and season in human lymphocytes","volume":"71","author":"Lenton","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1079\/BJN19810125","article-title":"Vitamin and mineral nutrition in chronic alcoholics including patients with Korsakoff\u2019s psychosis","volume":"45","author":"Devgun","year":"1981","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/1097-0142(19930801)72:3<783::AID-CNCR2820720325>3.0.CO;2-U","article-title":"Glutathione concentrations and variability in breast tumors and normal tissue","volume":"72","author":"Perry","year":"1993","journal-title":"Cancer"},{"key":"10.1093\/ajcn\/77.1.189_bib13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3835(94)90191-0","article-title":"Glutathione concentration in oral cancer tissues","volume":"81","author":"Wong","year":"1994","journal-title":"Cancer Lett"},{"key":"10.1093\/ajcn\/77.1.189_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ajcn\/70.1.49","article-title":"Serum vitamin C concentrations and diabetes: findings from the third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"70","author":"Will","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/bbrc.1998.8752","article-title":"Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants","volume":"247","author":"Yamamoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/ajcn\/77.1.189_bib16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1365-2362.2000.00736.x","article-title":"N-acetylcysteine replenishes glutathione in HIV infection","volume":"30","author":"De Rosa","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"10.1093\/ajcn\/77.1.189_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/07315724.2001.10719028","article-title":"Oxidative stress in cystic fibrosis: dietary and metabolic factors","volume":"20","author":"Wood","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib18","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1182\/blood.V88.9.3608.bloodjournal8893608","article-title":"Oxidative stress and antioxidant status in \u03b2-thalassemia major\u2014iron overload and depletion of lipid-soluble antioxidants","volume":"88","author":"Livrea","year":"1996","journal-title":"Blood"},{"key":"10.1093\/ajcn\/77.1.189_bib19","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1096\/fasebj.13.9.1007","article-title":"Does vitamin C act as a pro-oxidant under physiologic conditions?","volume":"13","author":"Carr","year":"1999","journal-title":"FASEB J"},{"key":"10.1093\/ajcn\/77.1.189_bib20","doi-asserted-by":"crossref","first-page":"9397","DOI":"10.1016\/S0021-9258(17)36891-6","article-title":"Glutathione ascorbic acid antioxidant system in animals","volume":"269","author":"Meister","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/77.1.189_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0925-4439(95)00007-Q","article-title":"Mitochondrial changes associated with glutathione deficiency","volume":"1271","author":"Meister","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1093\/ajcn\/77.1.189_bib22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2307\/3579271","article-title":"Catalytic metals, ascorbate and free radicals\u2014combinations to avoid","volume":"145","author":"Buettner","year":"1996","journal-title":"Radiat Res"},{"key":"10.1093\/ajcn\/77.1.189_bib23","first-page":"51","article-title":"A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a 1 g gravity field","volume":"97","author":"Boyum","year":"1968","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"10.1093\/ajcn\/77.1.189_bib24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/bj3060101","article-title":"Analysis of water-soluble antioxidants by high-pressure liquid chromatography","volume":"306","author":"Rose","year":"1995","journal-title":"Biochem J"},{"key":"10.1093\/ajcn\/77.1.189_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1024\/0300-9831.70.5.226","article-title":"Vitamin C concentrations in plasma as a function of intake: a meta-analysis","volume":"70","author":"Brubacher","year":"2000","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/ajcn\/77.1.189_bib26","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1073\/pnas.93.8.3704","article-title":"Vitamin C pharmacokinetics in healthy volunteers\u2014evidence for a recommended dietary allowance","volume":"93","author":"Levine","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/ajcn\/77.1.189_bib27","doi-asserted-by":"crossref","first-page":"9842","DOI":"10.1073\/pnas.171318198","article-title":"A new recommended dietary allowance of vitamin C for healthy young women","volume":"98","author":"Levine","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/ajcn\/77.1.189_bib28","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/carcin\/19.10.1873","article-title":"Age and sex dependent concentrations of glutathione and glutathione S-transferases in human lymphocytes","volume":"19","author":"van Lieshout","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1093\/ajcn\/77.1.189_bib29","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1096\/fj.00-0176com","article-title":"Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-\u03b1-lipoic acid","volume":"15","author":"Suh","year":"2001","journal-title":"FASEB J"},{"key":"10.1093\/ajcn\/77.1.189_bib30","first-page":"557","article-title":"Influence of bentonite and vitamin C on renal and hepatic glutathione in cadmium intoxicated rats","volume":"18","author":"Domanska","year":"2000","journal-title":"J Trace Microprobe Tech<<??>>"},{"key":"10.1093\/ajcn\/77.1.189_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0891-5849(98)00066-5","article-title":"Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion","volume":"25","author":"Haramaki","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"10.1093\/ajcn\/77.1.189_bib32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.2000.3930","article-title":"Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous","volume":"279","author":"Dalton","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/ajcn\/77.1.189_bib33","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0140-6736(05)78428-2","article-title":"Glutathione\u2014in sickness and in health","volume":"351","author":"Nuttall","year":"1998","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/77.1.189_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1067\/mlc.2000.105977","article-title":"Blood glutathione decreases in chronic diseases","volume":"135","author":"Lang","year":"2000","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/77.1.189_bib35","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1073\/pnas.94.5.1967","article-title":"Glutathione deficiency is associated with impaired survival in HIV disease","volume":"94","author":"Herzenberg","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/ajcn\/77.1.189_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/jn\/122.2.312","article-title":"Dietary vitamin C intake and concentrations in body fluids and cells of male smokers and non-smokers","volume":"122","author":"Bui","year":"1992","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1152\/jappl.1987.63.1.152","article-title":"Normal alveolar epithelial lining fluid contains high concentrations of glutathione","volume":"63","author":"Cantin","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1093\/ajcn\/77.1.189_bib38","first-page":"3642","article-title":"Frequent coordinated overexpression of the MRP\/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers","volume":"56","author":"Kuo","year":"1996","journal-title":"Cancer Res"},{"key":"10.1093\/ajcn\/77.1.189_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcn\/58.1.103","article-title":"Vitamin-C elevates red blood cell glutathione in healthy adults","volume":"58","author":"Johnston","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib40","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1046\/j.1365-2125.1997.00623.x","article-title":"The effect of pharmacologic supplementation with vitamin C on low-density lipoprotein oxidation","volume":"44","author":"Wen","year":"1997","journal-title":"Br J Clin Pharmacol"},{"key":"10.1093\/ajcn\/77.1.189_bib41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0022-3476(94)70309-4","article-title":"Effect of ascorbate or N-acetylcysteine treatment in a patient with hereditary glutathione synthetase deficiency","volume":"124","author":"Jain","year":"1994","journal-title":"J Pediatr"},{"key":"10.1093\/ajcn\/77.1.189_bib42","doi-asserted-by":"crossref","first-page":"23039","DOI":"10.1074\/jbc.273.36.23039","article-title":"Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase","volume":"273","author":"May","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/77.1.189_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1997.7812","article-title":"Recent trends in glutathione biochemistry\u2014glutathione-protein interactions: a molecular link between oxidative stress and cell proliferation?","volume":"242","author":"Cotgreave","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"issue":"suppl","key":"10.1093\/ajcn\/77.1.189_bib44","doi-asserted-by":"crossref","first-page":"1302S","DOI":"10.1093\/ajcn\/54.6.1302s","article-title":"Immunocompetence and oxidant defense during ascorbate depletion of healthy men","volume":"54","author":"Jacob","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.1.189_bib45","first-page":"133","article-title":"Ageing, nutritional status and immune response","volume":"68","author":"Buzina-Suboticanec","year":"1998","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/ajcn\/77.1.189_bib46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ajcn\/57.2.170","article-title":"Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners","volume":"57","author":"Peters","year":"1993","journal-title":"Am J Clin Nutr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523055892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523055892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/77\/1\/189\/23660147\/189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:38:57Z","timestamp":1733963937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523055892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0002916523055892"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/77.1.189","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/77.1.189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}