{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:30:15Z","timestamp":1782865815075,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":7239,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1093\/ajcn\/77.5.1304","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T04:03:35Z","timestamp":1516853015000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans"],"prefix":"10.1016","volume":"77","author":[{"given":"Francoise","family":"Briet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Twomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khursheed N","family":"Jeejeebhoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/77.5.1304_bib1","first-page":"196","article-title":"What is malnutrition? Does it matter?","volume":"11","author":"Kinosian","year":"1995","journal-title":"Nutrition"},{"key":"10.1093\/ajcn\/77.5.1304_bib2","first-page":"131","article-title":"How should we monitor nutritional support: structure or function?","volume":"2","author":"Jeejeebhoy","year":"1994","journal-title":"New Horiz"},{"key":"10.1093\/ajcn\/77.5.1304_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1079\/BJN19860059","article-title":"Nutrition and cellular immunity in hospital patients","volume":"55","author":"Dowd","year":"1986","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/014860718901300134","article-title":"Comparison of forearm muscle dynamometry with nutritional prognostic index, as a preoperative indicator in cancer patients","volume":"13","author":"Kalfarentzos","year":"1989","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"suppl","key":"10.1093\/ajcn\/77.5.1304_bib5","doi-asserted-by":"crossref","first-page":"460S","DOI":"10.1093\/ajcn\/66.2.460S","article-title":"Nutrition and the immune system: an introduction","volume":"66","author":"Chandra","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/014860719501900295","article-title":"Total enteral nutrition support improves body composition of patients with active Crohn\u2019s disease","volume":"19","author":"Royall","year":"1995","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib7","first-page":"95","article-title":"Nutrition and inflammatory bowel disease: an update","volume":"230","author":"Geerling","year":"1999","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1093\/ajcn\/77.5.1304_bib8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.ejcn.1601049","article-title":"Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls","volume":"54","author":"Geerling","year":"2000","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/ajcn\/67.5.919","article-title":"Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission","volume":"67","author":"Geerling","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib10","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/ajcn\/66.5.1063","article-title":"Distinguishing malnutrition from disease: the search goes on","volume":"66","author":"Weinsier","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib11","first-page":"932","article-title":"Increase of resting energy expenditure during flare-ups in Crohn disease","volume":"17","author":"Rigaud","year":"1993","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1093\/ajcn\/77.5.1304_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(99)05225-3","article-title":"Mitochondrial respiratory chain disorders I: mitochondrial DNA defects","volume":"355","author":"Leonard","year":"2000","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/77.5.1304_bib13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1172\/JCI116538","article-title":"Effect of fasting, hypocaloric feeding, and refeeding on the energetics of stimulated rat muscle as assessed by nuclear magnetic resonance spectroscopy","volume":"92","author":"Mijan de la Torre","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/77.5.1304_bib14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1172\/JCI113695","article-title":"Effect of dietary manipulations (fasting, hypocaloric feeding, and subsequent refeeding) on rat muscle energetics as assessed by nuclear magnetic resonance spectroscopy","volume":"82","author":"Pichard","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/77.5.1304_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ajcn\/73.5.975","article-title":"Effect of hypoenergetic feeding and refeeding on muscle and mononuclear cell activities of mitochondrial complexes I\u2013IV in enterally fed rats","volume":"73","author":"Briet","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib16","unstructured":"Madapallimattam AG, Law L, Jeejeebhoy KN. Effect of hypocaloric feeding on muscle oxidative phosphorylation and mitochondrial complex I\u2013IV activities in rats. Am J Clin Nutr (in press)."},{"key":"10.1093\/ajcn\/77.5.1304_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/37.1.133","article-title":"Skeletal muscle function during hypocaloric diets and fasting: a comparison with standard nutritional assessment parameters","volume":"37","author":"Russell","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib18","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/ajcn\/65.6.1845","article-title":"Refeeding improves muscle performance without normalization of muscle mass and oxygen consumption in anorexia nervosa patients","volume":"65","author":"Rigaud","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/ajcn\/62.1.30","article-title":"Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function, and immune response","volume":"62","author":"Castaneda","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib20","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group","volume":"69","author":"Dewys","year":"1980","journal-title":"Am J Med"},{"key":"10.1093\/ajcn\/77.5.1304_bib21","first-page":"25","article-title":"Prognostic factors for survival in patients with inoperable lung cancer","volume":"65","author":"Stanley","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/ajcn\/77.5.1304_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s Disease Study","volume":"70","author":"Best","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/77.5.1304_bib23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1152\/jappl.1998.85.3.1056","article-title":"Human hydrometry: comparison of multifrequency bioelectrical impedance with 2H2O and bromine dilution","volume":"85","author":"Ellis","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1093\/ajcn\/77.5.1304_bib24","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ajcn\/69.5.833","article-title":"Hydration of fat-free body mass: review and critique of a classic body-composition constant","volume":"69","author":"Wang","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib25","first-page":"222","article-title":"Calculation of energy expenditure from indirect calorimetry: assessment of the Weir equation","volume":"6","author":"Cunningham","year":"1990","journal-title":"Nutrition"},{"key":"10.1093\/ajcn\/77.5.1304_bib26","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g","volume":"97","author":"Boyum","year":"1968","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"10.1093\/ajcn\/77.5.1304_bib27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/bmmb.1994.1004","article-title":"An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria","volume":"51","author":"Birch-Machin","year":"1994","journal-title":"Biochem Med Metab Biol"},{"key":"10.1093\/ajcn\/77.5.1304_bib28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00075197-200007000-00013","article-title":"Dynamic assessment of fat-free mass during catabolism and recovery","volume":"3","author":"Kyle","year":"2000","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1093\/ajcn\/77.5.1304_bib29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/ajcn\/62.4.813","article-title":"Herman Award Lecture, 1995: infection-induced malnutrition\u2014from cholera to cytokines","volume":"62","author":"Beisel","year":"1995","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0899-9007(99)00281-6","article-title":"Energy metabolism and substrate oxidation in patients with Crohn\u2019s disease","volume":"16","author":"Al-Jaouni","year":"2000","journal-title":"Nutrition"},{"key":"10.1093\/ajcn\/77.5.1304_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ajcn\/53.1.161","article-title":"Resting and total energy expenditure in patients with inflammatory bowel disease","volume":"53","author":"Kushner","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib32","first-page":"3","article-title":"One month refeeding normalized mitochondrial complex I activity (CI) in malnourished patients while other nutritional assessment parameters remained abnormal","volume":"19","author":"Briet","year":"2000","journal-title":"Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/ajcn\/34.6.1109","article-title":"Febrile and plasma iron responses of rabbits injected with endogenous pyrogen from malnourished patients","volume":"34","author":"Hoffman-Goetz","year":"1981","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib34","first-page":"844","article-title":"An altered response by peripheral leukocytes to synthesize or release leukocyte endogenous mediator in critically ill, protein-malnourished patients","volume":"100","author":"Keenan","year":"1982","journal-title":"J Lab Clin Med"},{"key":"10.1093\/ajcn\/77.5.1304_bib35","first-page":"359","article-title":"Responses of the protein-deficient rabbit to staphylococcal bacteremia","volume":"69","author":"Bhuyan","year":"1972","journal-title":"Am J Pathol"},{"key":"10.1093\/ajcn\/77.5.1304_bib36","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0148607192016006561","article-title":"The role of protein and calorie restriction in outcome from Salmonella infection in mice","volume":"16","author":"Peck","year":"1992","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000658-198010000-00009","article-title":"Beneficial effects of aggressive protein feeding in severely burned children","volume":"192","author":"Alexander","year":"1980","journal-title":"Ann Surg"},{"key":"10.1093\/ajcn\/77.5.1304_bib38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ajcn\/27.6.647","article-title":"Effects of protein insufficiency on immune responsiveness","volume":"27","author":"Cooper","year":"1974","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/77.5.1304_bib39","first-page":"257","article-title":"Permissive underfeeding","volume":"2","author":"Zaloga","year":"1994","journal-title":"New Horiz"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523057787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523057787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/77\/5\/1304\/23660596\/1304.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T16:17:07Z","timestamp":1685377027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523057787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0002916523057787"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/77.5.1304","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/77.5.1304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}