{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:30:46Z","timestamp":1773408646076,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":7109,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1093\/ajcn\/78.3.441","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T05:12:14Z","timestamp":1516857134000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging"],"prefix":"10.1016","volume":"78","author":[{"given":"Joshua W","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa I","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay H","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M","family":"Mungas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary N","family":"Haan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/78.3.441_bib1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1001\/jama.1997.03540340052032","article-title":"Apolipoprotein E epsilon 4 and the risk of dementia with stroke: a population based investigation","volume":"277","author":"Slooter","year":"1997","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/78.3.441_bib2","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1136\/bmj.308.6944.1604","article-title":"Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam Study","volume":"308","author":"Breteler","year":"1994","journal-title":"BMJ"},{"key":"10.1093\/ajcn\/78.3.441_bib3","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.STR.28.4.777","article-title":"Cognitive deficits in peripheral vascular disease: a comparison of mild stroke patients and normal control subjects","volume":"28","author":"Phillips","year":"1997","journal-title":"Stroke"},{"key":"10.1093\/ajcn\/78.3.441_bib4","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1001\/jama.1995.03530230032026","article-title":"The association between midlife blood pressure levels and late-life cognitive function: the Honolulu-Asia Aging Study","volume":"274","author":"Launer","year":"1995","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/78.3.441_bib5","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1007\/s001250050588","article-title":"Association of diabetes mellitus and dementia: the Rotterdam Study","volume":"39","author":"Ott","year":"1996","journal-title":"Diabetologia"},{"key":"10.1093\/ajcn\/78.3.441_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"Refsum","year":"1998","journal-title":"Annu Rev Med"},{"key":"10.1093\/ajcn\/78.3.441_bib7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archneur.55.11.1449","article-title":"Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease","volume":"55","author":"Clarke","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1093\/ajcn\/78.3.441_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2362.1996.tb02129.x","article-title":"Hyperhomocysteinemia\u2014a common finding in a psychogeriatric population","volume":"26","author":"Nilsson","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"10.1093\/ajcn\/78.3.441_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/gerona\/52A.2.M76","article-title":"Is metabolic evidence for vitamin-B12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?","volume":"52","author":"Joosten","year":"1997","journal-title":"J Gerontol"},{"key":"10.1093\/ajcn\/78.3.441_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMoa011613","article-title":"Plasma homocysteine as a risk factor for dementia and Alzheimer's disease","volume":"346","author":"Seshadri","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/78.3.441_bib11","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1212\/WNL.58.10.1471","article-title":"Homocysteine, vitamin B6, and vascular disease in AD patients","volume":"58","author":"Miller","year":"2002","journal-title":"Neurology"},{"key":"10.1093\/ajcn\/78.3.441_bib12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0447.1992.tb03285.x","article-title":"Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people","volume":"86","author":"Bell","year":"1992","journal-title":"Acta Psychiatr Scand"},{"key":"10.1093\/ajcn\/78.3.441_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8","article-title":"Total serum homocysteine in senile dementia of the Alzheimer's type","volume":"13","author":"McCaddon","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1093\/ajcn\/78.3.441_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000017092","article-title":"Identification of cognitive impairment in the elderly: homocysteine is an early marker","volume":"10","author":"Lehmann","year":"1999","journal-title":"Dementia Geriatr Cogn Disord"},{"key":"10.1093\/ajcn\/78.3.441_bib15","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/clinchem\/46.5.691","article-title":"The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population","volume":"46","author":"Nilsson","year":"2000","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/78.3.441_bib16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/ajcn\/63.3.306","article-title":"Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study","volume":"63","author":"Riggs","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/78.3.441_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1749-6632.2000.tb06392.x","article-title":"Plasma total homocysteine and cognitive performance in a volunteer elderly population","volume":"903","author":"Budge","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1093\/ajcn\/78.3.441_bib18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/ajcn\/73.5.927","article-title":"Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey","volume":"73","author":"Morris","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/78.3.441_bib19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/75.5.908","article-title":"Homocysteine, B vitamin status, and cognitive function in the elderly","volume":"75","author":"Duthie","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/78.3.441_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.aje.a010000","article-title":"Total homocysteine and cognitive decline in a community-based sample of elderly subjects: the Rotterdam Study","volume":"150","author":"Kalmijn","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1093\/ajcn\/78.3.441_bib21","first-page":"218","article-title":"Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects","volume":"4","author":"Ravaglia","year":"2000","journal-title":"J Nutr Health Aging"},{"key":"10.1093\/ajcn\/78.3.441_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1212\/WNL.59.3.383","article-title":"Brain structure and cognition in a community sample of elderly Latinos","volume":"59","author":"Wu","year":"2002","journal-title":"Neurology"},{"key":"10.1093\/ajcn\/78.3.441_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/clinchem\/43.4.687","article-title":"Novel reductant for determination of total plasma homocysteine","volume":"43","author":"Gilfix","year":"1997","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/78.3.441_bib24","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"10.1093\/ajcn\/78.3.441_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/0894-4105.14.2.209","article-title":"Development of psychometrically matched English and Spanish language neuropsychological tests for older persons","volume":"14","author":"Mungas","year":"2000","journal-title":"Neuropsychology"},{"key":"10.1093\/ajcn\/78.3.441_bib26","first-page":"199","article-title":"An acculturation scale for Mexican American normal and clinical populations","volume":"2","author":"Cuellar","year":"1980","journal-title":"Hispanic J Behav Sci"},{"key":"10.1093\/ajcn\/78.3.441_bib27","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1046\/j.1532-5415.2001.49186.x","article-title":"Acculturation and the prevalence of depression in older Mexican Americans: baseline results of the Sacramento Area Latino Study on Aging","volume":"49","author":"Gonzalez","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"10.1093\/ajcn\/78.3.441_bib28","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/78.3.441_bib29","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1001\/jama.1993.03510220049033","article-title":"Vitamin status and intake as primary determinants of homocysteinemia in an elderly population","volume":"270","author":"Selhub","year":"1993","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/78.3.441_bib30","series-title":"Homocysteine and vascular disease.","first-page":"413","article-title":"An overview of the homocysteine lowering clinical trials","author":"Clarke","year":"2000"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522033299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522033299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/78\/3\/441\/23712069\/441.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T19:15:04Z","timestamp":1685387704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522033299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0002916522033299"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/78.3.441","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/78.3.441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}