{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:33Z","timestamp":1791299973596,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":6984,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1093\/ajcn\/79.1.80","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T11:28:39Z","timestamp":1517570919000},"page":"80-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":206,"title":["Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death"],"prefix":"10.1016","volume":"79","author":[{"given":"Wen-Qiang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C","family":"Abnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford M","family":"Dawsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Di","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine W","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Mark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/79.1.80_bib1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/jnci\/85.18.1483","article-title":"Nutrition intervention trials in Linxian, China: supplementation with specific vitamin\/mineral combinations, cancer incidence, and disease-specific mortality in the general population","volume":"85","author":"Blot","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/ajcn\/79.1.80_bib2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/jnci\/85.18.1492","article-title":"Nutrition intervention trials in Linxian, China: multiple vitamin\/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia","volume":"85","author":"Li","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/ajcn\/79.1.80_bib3","first-page":"1957","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial","volume":"276","author":"Clark","year":"1996","journal-title":"Nutritional Prevention of Cancer Study Group JAMA"},{"key":"10.1093\/ajcn\/79.1.80_bib4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1046\/j.1464-410x.1998.00630.x","article-title":"Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial","volume":"81","author":"Clark","year":"1998","journal-title":"Br J Urol"},{"key":"10.1093\/ajcn\/79.1.80_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02778987","article-title":"Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong","volume":"56","author":"Yu","year":"1997","journal-title":"Biol Trace Elem Res"},{"key":"10.1093\/ajcn\/79.1.80_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1207\/S15327914NC401_4","article-title":"Impact of selenium and cancer-prevention findings on the nutrition-health paradigm","volume":"40","author":"Combs","year":"2001","journal-title":"Nutr Cancer"},{"key":"10.1093\/ajcn\/79.1.80_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/biof.5520140120","article-title":"An analysis of cancer prevention by selenium","volume":"14","author":"Combs","year":"2001","journal-title":"Biofactors"},{"key":"10.1093\/ajcn\/79.1.80_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4615-1283-7_9","article-title":"Considering the mechanisms of cancer prevention by selenium","volume":"492","author":"Combs","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"10.1093\/ajcn\/79.1.80_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1079\/BJN2000280","article-title":"Selenium in global food systems","volume":"85","author":"Combs","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/79.1.80_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/978-1-4615-1283-7_10","article-title":"Selenium metabolism and mechanisms of cancer prevention","volume":"492","author":"Ganther","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"10.1093\/ajcn\/79.1.80_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4615-1283-7_11","article-title":"Apoptosis and angiogenesis in cancer prevention by selenium","volume":"492","author":"Lu","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"10.1093\/ajcn\/79.1.80_bib12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/1047-2797(93)90078-I","article-title":"Linxian nutrition intervention trials. Design, methods, participant characteristics, and compliance","volume":"3","author":"Li","year":"1993","journal-title":"Ann Epidemiol"},{"key":"10.1093\/ajcn\/79.1.80_bib13","first-page":"29","article-title":"Some considerations in the design of a nutrition intervention trial in Linxian, People's Republic of China","volume":"69","author":"Blot","year":"1985","journal-title":"Natl Cancer Inst Monogr"},{"key":"10.1093\/ajcn\/79.1.80_bib14","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/jnci\/92.21.1753","article-title":"Prospective study of serum selenium levels and incident esophageal and gastric cancers","volume":"92","author":"Mark","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/ajcn\/79.1.80_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/79.1.80_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/ije\/23.3.444","article-title":"A nested case-control study of oesophageal and stomach cancers in the Linxian nutrition intervention trial","volume":"23","author":"Guo","year":"1994","journal-title":"Int J Epidemiol"},{"key":"10.1093\/ajcn\/79.1.80_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00051313","article-title":"Retrospective cohort study of risk-factors for esophageal cancer in Linxian, People's Republic of China","volume":"4","author":"Yu","year":"1993","journal-title":"Cancer Causes Control"},{"key":"10.1093\/ajcn\/79.1.80_bib18","first-page":"1449","article-title":"Vitamin A and other deficiencies in Linxian, a high esophageal cancer incidence area in northern China","volume":"73","author":"Yang","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"10.1093\/ajcn\/79.1.80_bib19","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/01635588209513751","article-title":"Diet and vitamin nutrition of the high esophageal cancer risk population in Linxian, China","volume":"4","author":"Yang","year":"1982","journal-title":"Nutr Cancer"},{"key":"10.1093\/ajcn\/79.1.80_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/01635588509513848","article-title":"Comparison of riboflavin, vitamin A, and zinc status of Chinese populations at high and low risk for esophageal cancer","volume":"7","author":"Thurnham","year":"1985","journal-title":"Nutr Cancer"},{"key":"10.1093\/ajcn\/79.1.80_bib21","first-page":"190","article-title":"Nutritional status in Linxian, China: effects of season and supplementation","volume":"59","author":"Zheng","year":"1989","journal-title":"Int J Vitam Nutr Res"},{"key":"10.1093\/ajcn\/79.1.80_bib22","series-title":"Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids.","year":"2000"},{"key":"10.1093\/ajcn\/79.1.80_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/jn\/126.1.138","article-title":"Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects","volume":"126","author":"Hill","year":"1996","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/79.1.80_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0946-672X(11)80013-1","article-title":"Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity","volume":"9","author":"Neve","year":"1995","journal-title":"J Trace Elem Med Biol"},{"key":"10.1093\/ajcn\/79.1.80_bib25","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/ajcn\/70.5.896","article-title":"An estimation of selenium requirements for New Zealanders","volume":"70","author":"Duffield","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/79.1.80_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1523-5408.2002.00006.x","article-title":"Selenium, an antioxidant nutrient","volume":"5","author":"Burk","year":"2002","journal-title":"Nutr Clin Care"},{"key":"10.1093\/ajcn\/79.1.80_bib27","first-page":"630","article-title":"Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial","volume":"11","author":"Duffield-Lillico","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/79.1.80_bib28","first-page":"1285","article-title":"Selenium supplementation and lung cancer incidence: an update of the nutritional prevention of cancer trial","volume":"11","author":"Reid","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/79.1.80_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1078-1439(02)00301-0","article-title":"SELECT: the selenium and vitamin E cancer prevention trial","volume":"21","author":"Klein","year":"2003","journal-title":"Urol Oncol"},{"key":"10.1093\/ajcn\/79.1.80_bib30","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S0002-9149(99)80344-0","article-title":"Plasma levels of the antioxidant selenium and risk of myocardial infarction among U. S. physicians","volume":"76","author":"Salvini","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1093\/ajcn\/79.1.80_bib31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/ajcn\/45.2.462","article-title":"Serum selenium, vitamin antioxidants, and cardiovascular mortality: a 9-year follow-up study in the Netherlands","volume":"45","author":"Kok","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/79.1.80_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0140-6736(82)91028-5","article-title":"Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study","volume":"2","author":"Salonen","year":"1982","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/79.1.80_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0021-9150(92)90035-F","article-title":"Serum selenium concentration and risk of ischaemic heart disease in a prospective cohort study of 3000 males","volume":"96","author":"Suadicani","year":"1992","journal-title":"Atherosclerosis"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522037947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522037947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/79\/1\/80\/23713660\/znu00104000080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:38:05Z","timestamp":1733963885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522037947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0002916522037947"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/79.1.80","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/79.1.80","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}