{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:22:35Z","timestamp":1790893355817,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T00:00:00Z","timestamp":1677283200000},"content-version":"vor","delay-in-days":5626,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1093\/ajcn\/86.4.1187","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T00:20:46Z","timestamp":1518826846000},"page":"1187-1192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Proportion of individuals with low serum vitamin B-12 concentrations without macrocytosis is higher in the post\u2013folic acid fortification period than in the pre\u2013folic acid fortification period"],"prefix":"10.1016","volume":"86","author":[{"given":"Kelly F","family":"Wyckoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ganji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/86.4.1187_bib1","first-page":"8781","article-title":"Food standards: amendment of the standards of identity for enriched cereal-grain products to require the addition of folic acid: final rule","volume":"61","year":"1996","journal-title":"Fed Reg"},{"key":"10.1093\/ajcn\/86.4.1187_bib2","first-page":"8797","article-title":"Food additives permitted for direct addition to food for human consumption: folic acid: final rule","volume":"61","year":"1996","journal-title":"Fed Reg"},{"key":"10.1093\/ajcn\/86.4.1187_bib3","first-page":"131","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study","volume":"338","year":"1991","journal-title":"MRC Vitamin Study Research Period. Lancet"},{"key":"10.1093\/ajcn\/86.4.1187_bib4","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/86.4.1187_bib5","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1001\/jama.285.23.2981","article-title":"Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects","volume":"285","author":"Honein","year":"2001","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/86.4.1187_bib6","first-page":"9","article-title":"Spina bifida and anencephaly prevalence\u2014United States, 1991\u20132001","volume":"51","author":"Mathews","year":"2002","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1093\/ajcn\/86.4.1187_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/jn\/136.1.153","article-title":"Trends in serum folate, red blood cell folate, and circulating total homocysteine concentrations in the US: analysis of data from the National Health and Nutrition Examination Surveys, 1988\u20132002","volume":"136","author":"Ganji","year":"2006","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","article-title":"The effect of folic acid fortification on plasma folate and total homocysteine concentrations","volume":"340","author":"Jacques","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/86.4.1187_bib9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(99)03227-4","article-title":"Trends in serum folate after food fortification","volume":"354","author":"Lawrence","year":"1999","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/86.4.1187_bib10","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1093\/jn\/131.12.3277","article-title":"Folic acid fortification increases red blood cell folate concentrations in the Framingham study","volume":"131","author":"Choumenkovitch","year":"2001","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ajcn\/77.1.221","article-title":"Effect of food fortification on folic acid intake in the United States","volume":"77","author":"Quinlivan","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/ajcn\/84.5.989","article-title":"Population reference values for plasma total homocysteine concentrations in US adults after the fortification of cereals with folic acid","volume":"84","author":"Ganji","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib13","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1001\/jama.285.23.3022","article-title":"Food fortification to prevent neural tube defects: is it working?","volume":"285","author":"Mills","year":"2001","journal-title":"JAMA"},{"key":"10.1093\/ajcn\/86.4.1187_bib14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-2005-872400","article-title":"Case for folic acid and vitamin B-12 fortification in Europe","volume":"5","author":"Czernichow","year":"2002","journal-title":"Semin Vasc Med"},{"key":"10.1093\/ajcn\/86.4.1187_bib15","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1111\/j.1753-4887.2004.tb00076.x","article-title":"Modeling the level of fortification and post-fortification assessments: US experience","volume":"62","author":"Yetley","year":"2004","journal-title":"Nutr Rev"},{"key":"10.1093\/ajcn\/86.4.1187_bib16","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1056\/NEJM200005113421911","article-title":"Fortification of foods with folic acid\u2014how much is enough?","volume":"342","author":"Mills","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1093\/ajcn\/86.4.1187_bib17","series-title":"Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B-16, folate, vitamin B-12, pantothenic acid, biotin, and choline","year":"1998"},{"key":"10.1093\/ajcn\/86.4.1187_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ajcn\/60.1.2","article-title":"Prevalence of cobalamin deficiency in the Framingham elderly population","volume":"60","author":"Lindenbaum","year":"1994","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib19","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/ajcn\/77.6.1474","article-title":"Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain","volume":"77","author":"Mills","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0009-9120(03)00061-4","article-title":"Persistence of vitamin B-12 insufficiency among elderly women after folic acid food fortification","volume":"36","author":"Ray","year":"2003","journal-title":"Clin Biochem"},{"key":"10.1093\/ajcn\/86.4.1187_bib21","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/j.1753-4887.2004.tb00074.x","article-title":"Folic acid fortification of wheat flour: Chile","volume":"62","author":"Hertrampf","year":"2004","journal-title":"Nutr Rev"},{"key":"10.1093\/ajcn\/86.4.1187_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/68.2.328","article-title":"Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects","volume":"68","author":"van Asselt","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib23","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/jn\/132.9.2792","article-title":"Folic acid intake from fortification in United States exceeds predictions","volume":"132","author":"Choumenkovitch","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/jn\/132.2.289","article-title":"The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people","volume":"132","author":"Hirsch","year":"2002","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/86.4.1187_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0002-9629(15)40772-4","article-title":"Etiology and diagnostic evaluation of macrocytosis","volume":"319","author":"Savage","year":"2000","journal-title":"Am J Med Sci"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652313543X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652313543X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/86\/4\/1187\/23916725\/znu01007001187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T12:34:48Z","timestamp":1685190888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291652313543X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S000291652313543X"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/86.4.1187","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proportion of individuals with low serum vitamin B-12 concentrations without macrocytosis is higher in the post\u2013folic acid fortification period than in the pre\u2013folic acid fortification period","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/86.4.1187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}