{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:48Z","timestamp":1791267288629,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":5539,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1093\/ajcn\/87.1.156","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T01:26:10Z","timestamp":1518830770000},"page":"156-161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Effects of intraduodenal glucose, fat, and protein on blood pressure, heart rate, and splanchnic blood flow in healthy older subjects"],"prefix":"10.1016","volume":"87","author":[{"given":"Diana","family":"Gentilcore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trygve","family":"Hausken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/87.1.156_bib1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1532-5415.2005.53415.x","article-title":"Postprandial hypotension predicts all-cause mortality in older, low-level care residents.","volume":"53","author":"Fisher","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1093\/ajcn\/87.1.156_bib2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.7326\/0003-4819-122-4-199502150-00009","article-title":"Postprandial hypotension: epidemiology, pathophysiology, and clinical management.","volume":"122","author":"Jansen","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/87.1.156_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.7326\/0003-4819-115-11-865","article-title":"Frequency and importance of postprandial blood pressure reduction in elderly nursing-home patients.","volume":"115","author":"Vaitkevicius","year":"1991","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/87.1.156_bib4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1532-5415.1997.tb05965.x","article-title":"Association of postprandial hypotension with incidence of falls, syncope, coronary events, stroke, and total mortality at 29-month follow-up in 499 older nursing home residents.","volume":"45","author":"Aronow","year":"1997","journal-title":"J Am Geriatr Soc"},{"key":"10.1093\/ajcn\/87.1.156_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2362.1990.tb02268.x","article-title":"The effect of oral glucose, protein, fat and water loading on blood pressure and the gastrointestinal peptides VIP and somatostatin in hypertensive elderly subjects.","volume":"20","author":"Jansen","year":"1990","journal-title":"Eur J Clin Invest"},{"key":"10.1093\/ajcn\/87.1.156_bib6","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.amjmed.2005.05.019","article-title":"Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly.","volume":"118","author":"Gentilcore","year":"2005","journal-title":"Am J Med"},{"key":"10.1093\/ajcn\/87.1.156_bib7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1079\/BJN20051401","article-title":"The effects of drinks made from simple sugars on blood pressure in healthy older people.","volume":"93","author":"Visvanathan","year":"2005","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/87.1.156_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01824990","article-title":"Effects of carbohydrate type on postprandial blood pressure, neuroendocrine and gastrointestinal hormone changes in the elderly.","volume":"1","author":"Heseltine","year":"1991","journal-title":"Clin Autonom Res"},{"key":"10.1093\/ajcn\/87.1.156_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.2001.013442","article-title":"Postprandial hypotension in response to duodenal glucose delivery in healthy older subjects.","volume":"540","author":"O'Donovan","year":"2002","journal-title":"J Physiol"},{"key":"10.1093\/ajcn\/87.1.156_bib10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/cs0940065","article-title":"Rate of gastric emptying is a determinant of postprandial hypotension in non-insulin-dependent diabetes mellitus.","volume":"94","author":"Jones","year":"1998","journal-title":"Clin Sci (Lond)"},{"key":"10.1093\/ajcn\/87.1.156_bib11","first-page":"G240","article-title":"Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects.","volume":"289","author":"Jones","year":"2005","journal-title":"Am J Physiol"},{"key":"10.1093\/ajcn\/87.1.156_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-510X(98)00276-7","article-title":"Stomach distension increases efferent muscle sympathetic nerve activity and blood pressure in healthy humans.","volume":"161","author":"Rossi","year":"1998","journal-title":"J Neurol Sci"},{"key":"10.1093\/ajcn\/87.1.156_bib13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0002-9343(02)01025-2","article-title":"Water drinking as a treatment for orthostatic syndromes.","volume":"112","author":"Shannon","year":"2002","journal-title":"Am J Med"},{"key":"10.1093\/ajcn\/87.1.156_bib14","first-page":"A324","article-title":"Gastric distension attenuates the hypotensive response to intraduodenal glucose in healthy older subjects.","volume":"132","author":"Gentilcore","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/87.1.156_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/cs0770265","article-title":"Effects of meal composition on the postprandial blood pressure, catecholamine and insulin changes in elderly subjects.","volume":"77","author":"Potter","year":"1989","journal-title":"Clin Sci"},{"key":"10.1093\/ajcn\/87.1.156_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1748-1716.1992.tb09426.x","article-title":"Post-prandial cardiovascular responses in man after ingestion of carbohydrate, protein or fat.","volume":"146","author":"Waaler","year":"1992","journal-title":"Acta Physiol Scand"},{"key":"10.1093\/ajcn\/87.1.156_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1042\/cs0840263","article-title":"Cardiovascular responses to a high-fat and a high-carbohydrate meal in healthy elderly subjects.","volume":"84","author":"Sidery","year":"1993","journal-title":"Clin Sci (Lond)"},{"key":"10.1093\/ajcn\/87.1.156_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1042\/cs0900473","article-title":"Central and peripheral haemodynamic responses to high carbohydrate and high fat meals in human cardiac transplant recipients.","volume":"90","author":"Kearney","year":"1996","journal-title":"Clin Sci (Lond)"},{"key":"10.1093\/ajcn\/87.1.156_bib19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1079\/BJN20051633","article-title":"The hypotensive response to oral fat is comparable but slower compared with carbohydrate in healthy elderly subjects.","volume":"95","author":"Visvanathan","year":"2006","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/87.1.156_bib20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.7326\/0003-4819-103-6-889","article-title":"Prevention of postprandial hypotension with somatostatin.","volume":"103","author":"Hoeldtke","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1093\/ajcn\/87.1.156_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0016-5085(83)80232-7","article-title":"Regulation of the gastric emptying of glucose.","volume":"85","author":"Brener","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/87.1.156_bib22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1440-1746.1989.tb01741.x","article-title":"Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion.","volume":"4","author":"Heddle","year":"1989","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1093\/ajcn\/87.1.156_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1113\/jphysiol.1978.sp012161","article-title":"The slowing of gastric emptying by proteins in test meals.","volume":"274","author":"Burn-Murdoch","year":"1978","journal-title":"J Physiol"},{"key":"10.1093\/ajcn\/87.1.156_bib24","first-page":"G612","article-title":"Role of lipase in the regulation of upper gastrointestinal function in humans.","volume":"273","author":"Schwizer","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1093\/ajcn\/87.1.156_bib25","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/gast.2001.23232","article-title":"Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in humans.","volume":"120","author":"Feinle","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/87.1.156_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1079\/PNS19850011","article-title":"Protein digestion and amino acid and peptide absorption.","volume":"44","author":"Silk","year":"1985","journal-title":"Proc Nutr Soc"},{"key":"10.1093\/ajcn\/87.1.156_bib27","first-page":"1283","article-title":"Gastric emptying and intragastric distribution of oil in the presence of a liquid or a solid meal.","volume":"33","author":"Edelbroek","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1093\/ajcn\/87.1.156_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/01.CIR.87.2.391","article-title":"Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension.","volume":"87","author":"Lipsitz","year":"1993","journal-title":"Circulation"},{"key":"10.1093\/ajcn\/87.1.156_bib29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/00365528809093842","article-title":"Effects of ingestion of carbohydrate, fat, protein, and water on the mesenteric blood flow in man.","volume":"23","author":"Qamar","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"10.1093\/ajcn\/87.1.156_bib30","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/0016-5085(88)90364-2","article-title":"Duplex ultrasound measurement of postprandial intestinal blood flow: effect of meal composition.","volume":"95","author":"Moneta","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/87.1.156_bib31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/gut.35.2.186","article-title":"Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals.","volume":"35","author":"Sidery","year":"1994","journal-title":"Gut"},{"key":"10.1093\/ajcn\/87.1.156_bib32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1136\/gut.33.4.497","article-title":"Intestinal phase of superior mesenteric artery blood flow in man.","volume":"33","author":"Sieber","year":"1992","journal-title":"Gut"},{"key":"10.1093\/ajcn\/87.1.156_bib33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1079\/BJN19940190","article-title":"The effect of meal size on the cardiovascular responses to food ingestion.","volume":"71","author":"Sidery","year":"1994","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/87.1.156_bib34","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s10620-006-3187-y","article-title":"Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.","volume":"51","author":"Gentilcore","year":"2006","journal-title":"Dig Dis Sci"},{"key":"10.1093\/ajcn\/87.1.156_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/ejvs.2001.1313","article-title":"Duplex ultrasound for assessment of superior mesenteric artery blood flow.","volume":"21","author":"Perko","year":"2001","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1093\/ajcn\/87.1.156_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1475-097X.1991.tb00459.x","article-title":"Cardiovascular autonomic reflex tests: normal responses and age-related reference values.","volume":"11","author":"Piha","year":"1991","journal-title":"Clin Physiol"},{"key":"10.1093\/ajcn\/87.1.156_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/cs0770085","article-title":"Differential blood pressure and hormonal effects after glucose and xylose ingestion in chronic autonomic failure.","volume":"77","author":"Mathias","year":"1989","journal-title":"Clin Sci (Lond)"},{"key":"10.1093\/ajcn\/87.1.156_bib38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF00400362","article-title":"Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects.","volume":"36","author":"Horowitz","year":"1993","journal-title":"Diabetologia"},{"key":"10.1093\/ajcn\/87.1.156_bib39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/gerona\/60.7.940","article-title":"Intraduodenal guar attenuates the fall in blood pressure induced by glucose in healthy older adults.","volume":"60","author":"O'Donovan","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1093\/ajcn\/87.1.156_bib40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0031-9384(95)02113-2","article-title":"Higher-protein foods produce greater sensory-specific satiety.","volume":"59","author":"Vandewater","year":"1996","journal-title":"Physiol Behav"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523234498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523234498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/87\/1\/156\/23918529\/znu00108000156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:43:06Z","timestamp":1733964186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523234498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0002916523234498"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/87.1.156","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of intraduodenal glucose, fat, and protein on blood pressure, heart rate, and splanchnic blood flow in healthy older subjects","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/87.1.156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}