{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:33:07Z","timestamp":1760646787671},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":5511,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1093\/ajcn\/87.2.498s","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T01:21:38Z","timestamp":1518830498000},"page":"498S-503S","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mechanisms by which botanical lipids affect inflammatory disorders"],"prefix":"10.1016","volume":"87","author":[{"given":"Floyd H","family":"Chilton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence L","family":"Rudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S","family":"Parks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P","family":"Arm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Seeds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/87.2.498S_bib1","unstructured":"American Lung Association website.Asthma and adults fact sheet. Version current August 2006.Internet: http:\/\/www.lungusa.org(accessed 20 May 2007)."},{"key":"10.1093\/ajcn\/87.2.498S_bib2","unstructured":"American Heart Association.Internet: http:\/\/www.americanheart.org(accessed 20 May 2007)."},{"key":"10.1093\/ajcn\/87.2.498S_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cardiores.2006.08.019","article-title":"Cardiovascular benefits of omega-3 fatty acids.","volume":"73","author":"von Schacky","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1093\/ajcn\/87.2.498S_bib4","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1172\/JCI4164","article-title":"Lipoprotein clearance mechanisms in LDL receptor-deficient \u201cApo-B48-only\u201d and \u201cApo-B100-only\u201d mice.","volume":"102","author":"Veniant","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/87.2.498S_bib5","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1172\/JCI10695","article-title":"Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100.","volume":"106","author":"Veniant","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1093\/ajcn\/87.2.498S_bib6","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1073\/pnas.93.13.6393","article-title":"Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.","volume":"93","author":"Farese","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1093\/ajcn\/87.2.498S_bib7","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1161\/ATVBAHA.107.142802","article-title":"Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-\/- mice.","volume":"27","author":"Bell","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1093\/ajcn\/87.2.498S_bib8","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/jn\/134.6.1406","article-title":"Dietary Echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans.","volume":"134","author":"Surette","year":"2004","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/87.2.498S_bib9","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/art.1780331010","article-title":"Alteration of the cellular fatty acid profile and the production of eicosanoids in human monocytes by gamma-linolenic acid.","volume":"33","author":"Pullman-Mooar","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1093\/ajcn\/87.2.498S_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ajcn\/55.1.39","article-title":"Dose-response effects of dietary gamma-linolenic acid-enriched oils on human polymorphonuclear-neutrophil biosynthesis of leukotriene B4.","volume":"55","author":"Ziboh","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.2.498S_bib11","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.4049\/jimmunol.156.8.2941","article-title":"Metabolism of gammalinolenic acid in human neutrophils.","volume":"156","author":"Chilton","year":"1996","journal-title":"J Immunol"},{"key":"10.1093\/ajcn\/87.2.498S_bib12","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0006-291X(88)81166-5","article-title":"Ability of 15-hydroxyeicosatrienoic acid (15-OH-20:3) to modulate macrophage arachidonic acid metabolism.","volume":"153","author":"Chapkin","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/ajcn\/87.2.498S_bib13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0149-2918(03)80116-9","article-title":"Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects.","volume":"25","author":"Surette","year":"2003","journal-title":"Clin Therapeutics"},{"key":"10.1093\/ajcn\/87.2.498S_bib14","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/jn\/130.8.1925","article-title":"Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans.","volume":"130","author":"Barham","year":"2000","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/87.2.498S_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.plefa.2003.11.008","article-title":"The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers.","volume":"70","author":"Miles","year":"2004","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1093\/ajcn\/87.2.498S_bib16","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/ajcn\/77.5.1140","article-title":"Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n\u22123 fatty acids.","volume":"77","author":"James","year":"2003","journal-title":"Am J Clin Nutr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523235042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523235042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/87\/2\/498S\/23918705\/ajc0020800498s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T21:11:24Z","timestamp":1685135484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523235042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0002916523235042"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/87.2.498s","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms by which botanical lipids affect inflammatory disorders","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/87.2.498S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}