{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:49:35Z","timestamp":1779878975010,"version":"3.53.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":5482,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1093\/ajcn\/87.3.723","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T01:23:50Z","timestamp":1518830630000},"page":"723-733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiency"],"prefix":"10.1016","volume":"87","author":[{"given":"Sara E","family":"Wuehler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Semp\u00e9rtegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth H","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/87.3.723_bib1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1542\/peds.2006-3481","article-title":"Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis.","volume":"119","author":"Aggarwal","year":"2007","journal-title":"Pediatrics"},{"key":"10.1093\/ajcn\/87.3.723_bib2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0022-3476(99)70086-7","article-title":"Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group.","volume":"135","author":"Bhutta","year":"1999","journal-title":"J Pediatr"},{"key":"10.1093\/ajcn\/87.3.723_bib3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1136\/bmj.325.7372.1059","article-title":"Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial.","volume":"325","author":"Baqui","year":"2002","journal-title":"BMJ"},{"key":"10.1093\/ajcn\/87.3.723_bib4","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/bmj.322.7302.1567","article-title":"Effect of zinc supplementation on malaria and other causes of morbidity in west African children: randomised double blind placebo controlled trial.","volume":"322","author":"Mu\u00d6ller","year":"2001","journal-title":"BMJ"},{"key":"10.1093\/ajcn\/87.3.723_bib5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1542\/peds.108.6.1280","article-title":"Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial.","volume":"108","author":"Sazawal","year":"2001","journal-title":"Pediatrics"},{"key":"10.1093\/ajcn\/87.3.723_bib6","first-page":"433","article-title":"Therapeutic evaluation of zinc and copper supplementation in acute diarrhea in children: double blind randomized trial.","volume":"42","author":"Patel","year":"2005","journal-title":"Indian Pediatr"},{"key":"10.1093\/ajcn\/87.3.723_bib7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(05)67109-7","article-title":"Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial.","volume":"366","author":"Brooks","year":"2005","journal-title":"Lancet"},{"key":"10.1093\/ajcn\/87.3.723_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/bmj.39035.482396.55","article-title":"Effects of fortified milk on morbidity in young children in north India: community based, randomised, double masked placebo controlled trial.","volume":"334","author":"Sazawal","year":"2007","journal-title":"BMJ"},{"key":"10.1093\/ajcn\/87.3.723_bib9","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/ajcn\/75.6.1062","article-title":"Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials.","volume":"75","author":"Brown","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib10","article-title":"Recommended dietary allowances.","year":"1989"},{"key":"10.1093\/ajcn\/87.3.723_bib11","article-title":"Trace elements in human nutrition and health.","year":"1996"},{"key":"10.1093\/ajcn\/87.3.723_bib12","article-title":"Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc.","year":"2001"},{"key":"10.1093\/ajcn\/87.3.723_bib13","first-page":"S99","article-title":"International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control.","volume":"25","author":"Brown","year":"2004","journal-title":"Food Nutr Bull"},{"key":"10.1093\/ajcn\/87.3.723_bib14","article-title":"Vitamin and mineral requirements in human nutrition.","year":"2004"},{"key":"10.1093\/ajcn\/87.3.723_bib15","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/ajcn\/78.5.1011","article-title":"Zinc intake of US preschool children exceeds new dietary reference intakes.","volume":"78","author":"Arsenault","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib16","first-page":"929","article-title":"Use and interpretation of anthropometric indicators of nutritional status. WHO Working Group.","volume":"64","year":"1986","journal-title":"Bull World Health Organ"},{"key":"10.1093\/ajcn\/87.3.723_bib17","doi-asserted-by":"crossref","first-page":"S480","DOI":"10.1177\/15648265070283S306","article-title":"Conclusions of the Joint WHO\/UNICEF\/IAEA\/IZiNCG Interagency Meeting on Zinc Status Indicators.","volume":"28","author":"de Benoist","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.1093\/ajcn\/87.3.723_bib18","series-title":"Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia.","article-title":"International Nutritional Anemia Consultative Group I.","author":"Stoltzfus","year":"1998"},{"key":"10.1093\/ajcn\/87.3.723_bib19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/ajcn\/54.1.152","article-title":"Competitive inhibition of iron absorption by manganese and zinc in humans.","volume":"54","author":"Rossander-Hulten","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib20","first-page":"1735","article-title":"Aspects of trace element interactions during development.","volume":"42","author":"Hurley","year":"1983","journal-title":"Fed Proc"},{"key":"10.1093\/ajcn\/87.3.723_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/jn\/116.6.927","article-title":"Competitive interaction of iron and zinc in the diet: consequences for human nutrition.","volume":"116","author":"Solomons","year":"1986","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib22","first-page":"625","article-title":"Altitude correction for hemoglobin.","volume":"48","author":"Dirren","year":"1994","journal-title":"Eur J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib23","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/clinchem\/20.12.1556","article-title":"Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride.","volume":"20","author":"Schosinsky","year":"1974","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/87.3.723_bib24","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/clinchem\/20.12.1564","article-title":"Standardization of serum ceruloplasmin concentrations in international enzyme units with o-dianisidine dihydrochloride as substrate.","volume":"20","author":"Lehmann","year":"1974","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/87.3.723_bib25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-8981(99)00246-6","article-title":"A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1).","volume":"293","author":"Peskin","year":"2000","journal-title":"Clin Chim Acta"},{"key":"10.1093\/ajcn\/87.3.723_bib26","article-title":"Anthropometric indicators measurement guide.","author":"Cogill","year":"2003"},{"key":"10.1093\/ajcn\/87.3.723_bib27","unstructured":"World Health Organization.WHO Anthro 2005 for personal computers.Internet:www.who.int\/childgrowth\/software\/en\/(accessed 17 July 2006)."},{"key":"10.1093\/ajcn\/87.3.723_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/ajcn\/43.1.47","article-title":"Zinc tolerance tests in zinc deficient and zinc supplemented diets.","volume":"43","author":"Fickel","year":"1986","journal-title":"Am J Clin Nutr"},{"issue":"suppl","key":"10.1093\/ajcn\/87.3.723_bib29","doi-asserted-by":"crossref","first-page":"S403","DOI":"10.1177\/15648265070283S303","article-title":"Use of serum zinc concentration as an indicator of population zinc status.","volume":"28","author":"Hess","year":"2007","journal-title":"Food Nutr Bull"},{"key":"10.1093\/ajcn\/87.3.723_bib30","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/ajcn\/81.3.637","article-title":"Longitudinal measurements of zinc absorption in Peruvian children consuming wheat products fortified with iron only or iron and 1 of 2 amounts of zinc.","volume":"81","author":"Lo\u00f2pez de Roma\u00f1a","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib31","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0016-5085(82)80138-8","article-title":"Technique for determination of human zinc absorption from measurement of radioactivity in a fecal sample or the body.","volume":"83","author":"Payton","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1093\/ajcn\/87.3.723_bib32","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/ajcn\/80.6.1570","article-title":"Zinc absorption as a function of the dose of zinc sulfate in aqueous solution.","volume":"80","author":"Tran","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib33","article-title":"Complementary feeding of young children in developing countries: a review of current scientific knowledge.","author":"Brown","year":"1998"},{"key":"10.1093\/ajcn\/87.3.723_bib34","first-page":"G87","article-title":"Zinc absorption in human small intestine.","volume":"256","author":"Lee","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1093\/ajcn\/87.3.723_bib35","first-page":"G176","article-title":"Interaction between transport of zinc and other solutes in human intestine.","volume":"247","author":"Steinhardt","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1093\/ajcn\/87.3.723_bib36","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1093\/jn\/135.9.2187","article-title":"Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants.","volume":"135","author":"Baqui","year":"2005","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1079\/BJN19930026","article-title":"A trial of zinc supplementation in young rural Gambian children.","volume":"69","author":"Bates","year":"1993","journal-title":"Br J Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib38","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1542\/peds.109.6.e86","article-title":"Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young North Indian children.","volume":"109","author":"Bhandari","year":"2002","journal-title":"Pediatrics"},{"key":"10.1093\/ajcn\/87.3.723_bib39","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/ajcn\/77.4.883","article-title":"A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc.","volume":"77","author":"Lind","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib40","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1093\/ajcn\/66.6.1406","article-title":"A 14-mo zinc-supplementation trial in apparently healthy Chilean preschool children.","volume":"66","author":"Ruz","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/87.3.723_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1651-2227.2004.tb18254.x","article-title":"Zinc supplementation for four months does not affect plasma copper concentration in infants.","volume":"93","author":"Sazawal","year":"2004","journal-title":"Acta Paediatr"},{"key":"10.1093\/ajcn\/87.3.723_bib42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/ajcn\/38.2.195","article-title":"Linear growth of low income preschool children receiving a zinc supplement.","volume":"38","author":"Walravens","year":"1983","journal-title":"Am J Clin Nutr"}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523235200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916523235200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/87\/3\/723\/23918926\/znu00308000723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T08:01:54Z","timestamp":1685174514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916523235200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0002916523235200"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/87.3.723","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-response trial of prophylactic zinc supplements, with or without copper, in young Ecuadorian children at risk of zinc deficiency","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/87.3.723","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}