{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:41:29Z","timestamp":1768837289475,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013348","name":"Innosuisse - Swiss Innovation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1093\/ajcn\/nqab361","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T11:08:54Z","timestamp":1635419334000},"page":"949-957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Kinetics of iron absorption from ferrous fumarate with and without galacto-oligosaccharides determined from stable isotope appearance curves in women"],"prefix":"10.1016","volume":"115","author":[{"given":"Frederike MD","family":"Husmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Stierli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic S","family":"Br\u00e4m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-3708","authenticated-orcid":false,"given":"Christophe","family":"Zeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-4340","authenticated-orcid":false,"given":"Stefanie D","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0134-6217","authenticated-orcid":false,"given":"Isabelle","family":"Herter-Aeberli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/nqab361_bib1","unstructured":"WHO. Essential nutrition actions: mainstreaming nutrition through the life-course. Geneva; 2019"},{"key":"10.1093\/ajcn\/nqab361_bib2","unstructured":"WHO. Guideline: daily iron supplementation in adult women and adolescent girls. Geneva; 2016."},{"key":"10.1093\/ajcn\/nqab361_bib3","unstructured":"WHO. Iron deficiency anaemia: assessment, prevention and control. Geneva; 2001."},{"key":"10.1093\/ajcn\/nqab361_bib4","unstructured":"WHO. Guidelines on food fortification with micronutrients. Geneva; 2006."},{"issue":"6","key":"10.1093\/ajcn\/nqab361_bib5","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3945\/ajcn.114.103366","article-title":"Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review","volume":"102","author":"Peyrin-Biroulet","year":"2015","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/ajcn\/nqab361_bib6","series-title":"Guidelines on food fortification with micronutrients.","year":"2006"},{"issue":"4","key":"10.1093\/ajcn\/nqab361_bib7","doi-asserted-by":"crossref","first-page":"806S","DOI":"10.1093\/jn\/132.4.806S","article-title":"Fortification: overcoming technical and practical barriers","volume":"132","author":"Hurrell","year":"2002","journal-title":"J Nutr."},{"issue":"2","key":"10.1093\/ajcn\/nqab361_bib8","doi-asserted-by":"crossref","first-page":"e0117383","DOI":"10.1371\/journal.pone.0117383","article-title":"Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis","volume":"10","author":"Tolkien","year":"2015","journal-title":"PLoS One."},{"issue":"4","key":"10.1093\/ajcn\/nqab361_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1185\/03007995.2012.761599","article-title":"Tolerability of different oral iron supplements: a systematic review","volume":"29","author":"Cancelo-Hidalgo","year":"2013","journal-title":"Curr Med Res Opin."},{"issue":"5","key":"10.1093\/ajcn\/nqab361_bib10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jn\/nxy327","article-title":"Consumption of galacto-oligosaccharides increases iron absorption from ferrous fumarate: a stable iron isotope study in iron-depleted young women","volume":"149","author":"Jeroense","year":"2019","journal-title":"J Nutr."},{"issue":"9","key":"10.1093\/ajcn\/nqab361_bib11","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1093\/jn\/nxaa199","article-title":"Acute consumption of prebiotic galacto-oligosaccharides increases iron absorption from ferrous fumarate, but not from ferrous sulfate and ferric pyrophosphate: stable iron isotope studies in iron-depleted young women","volume":"150","author":"Jeroense","year":"2020","journal-title":"J Nutr."},{"issue":"5","key":"10.1093\/ajcn\/nqab361_bib12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1541-4337.2010.00119.x","article-title":"Galacto-oligosaccharides: production, properties, applications, and significance as prebiotics","volume":"9","author":"Torres","year":"2010","journal-title":"Compr Rev Food Sci F."},{"key":"10.1093\/ajcn\/nqab361_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnut.2019.00078","article-title":"Technological aspects of the production of fructo- and galacto-oligosaccharides. Enzymatic synthesis and hydrolysis","volume":"6","author":"Martins","year":"2019","journal-title":"Front Nutr."},{"issue":"5","key":"10.1093\/ajcn\/nqab361_bib14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jn\/nxy327","article-title":"Consumption of galacto-oligosaccharides increases iron absorption from ferrous fumarate: a stable iron isotope study in iron-depleted young women","volume":"149","author":"Jeroense","year":"2019","journal-title":"J Nutr."},{"issue":"5","key":"10.1093\/ajcn\/nqab361_bib15","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1111\/j.1365-2621.2005.tb09984.x","article-title":"Prebiotics and iron bioavailability\u2013is there a connection?","volume":"70","author":"Yeung","year":"2005","journal-title":"J Food Sci."},{"key":"10.1093\/ajcn\/nqab361_bib16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1182\/blood.V24.5.577.577","article-title":"Iron absorption: effects of sugars and reducing agents","volume":"24","author":"Pollack","year":"1964","journal-title":"Blood."},{"key":"10.1093\/ajcn\/nqab361_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-3002(63)91264-2","article-title":"Chelation of iron by sugars","volume":"69","author":"Charley","year":"1963","journal-title":"Biochim Biophys Acta."},{"issue":"12","key":"10.1093\/ajcn\/nqab361_bib18","doi-asserted-by":"crossref","first-page":"e83031","DOI":"10.1371\/journal.pone.0083031","article-title":"Sugars increase non-heme iron bioavailability in human epithelial intestinal and liver cells","volume":"8","author":"Christides","year":"2013","journal-title":"PLoS One."},{"issue":"7484","key":"10.1093\/ajcn\/nqab361_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature."},{"issue":"2","key":"10.1093\/ajcn\/nqab361_bib20","doi-asserted-by":"crossref","first-page":"459s","DOI":"10.1093\/ajcn\/73.2.459s","article-title":"Effects of prebiotics on mineral metabolism","volume":"73","author":"Scholz-Ahrens","year":"2001","journal-title":"Am J Clin Nutr."},{"issue":"12","key":"10.1093\/ajcn\/nqab361_bib21","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1021\/jf900698x","article-title":"Dietary inulin supplementation does not promote colonic iron absorption in a porcine model","volume":"57","author":"Patterson","year":"2009","journal-title":"J Agric Food Chem."},{"issue":"S1","key":"10.1093\/ajcn\/nqab361_bib22","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.24.1_supplement.208.1","article-title":"Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin","volume":"24","author":"Troesch","year":"2010","journal-title":"FASEB J."},{"issue":"5","key":"10.1093\/ajcn\/nqab361_bib23","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3945\/jn.110.136127","article-title":"Fortification iron as ferrous sulfate plus ascorbic acid is more rapidly absorbed than as sodium iron EDTA but neither increases serum nontransferrin-bound iron in women","volume":"141","author":"Troesch","year":"2011","journal-title":"J Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqab361_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/cs0870091","article-title":"Comparison of stable isotopes and radioisotopes in the measurement of iron absorption in healthy women","volume":"87","author":"Barrett","year":"1994","journal-title":"Clin Sci."},{"issue":"10","key":"10.1093\/ajcn\/nqab361_bib25","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1093\/ajcn\/34.10.2248","article-title":"An in vitro method for estimation of iron availability from meals","volume":"34","author":"Miller","year":"1981","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqab361_bib26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/ajcn\/47.1.102","article-title":"Iron absorption in humans: bovine serum albumin compared with beef muscle and egg white","volume":"47","author":"Hurrell","year":"1988","journal-title":"Am J Clin Nutr."},{"issue":"11","key":"10.1093\/ajcn\/nqab361_bib27","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/jn\/134.11.3127","article-title":"Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique","volume":"134","author":"Erhardt","year":"2004","journal-title":"J Nutr."},{"key":"10.1093\/ajcn\/nqab361_bib28","unstructured":"WHO. Iron deficiency anemia: assessment, prevention and Control. Geneva; 2001."},{"issue":"2","key":"10.1093\/ajcn\/nqab361_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00775-011-0851-2","article-title":"Mobilization of storage iron is reflected in the iron isotopic composition of blood in humans","volume":"17","author":"Hotz","year":"2012","journal-title":"J Biol Inorg Chem."},{"issue":"4-5","key":"10.1093\/ajcn\/nqab361_bib30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s002160050608","article-title":"Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal","volume":"359","author":"Walczyk","year":"1997","journal-title":"Fresenius J Anal Chem."},{"issue":"12","key":"10.1093\/ajcn\/nqab361_bib31","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1172\/JCI104677","article-title":"Red cell, plasma, and blood volume in healthy women measured by radichromium cell-labeling and hematocrit","volume":"41","author":"Brown","year":"1962","journal-title":"J Clin Invest."},{"issue":"1","key":"10.1093\/ajcn\/nqab361_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0147-6513(03)00051-4","article-title":"Monitoring approaches to assess bioaccessibility and bioavailability of metals: matrix issues","volume":"56","author":"Peijnenburg","year":"2003","journal-title":"Ecotoxicol Environ Saf."},{"issue":"4","key":"10.1093\/ajcn\/nqab361_bib33","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1079\/BJN20051722","article-title":"Iron solubility compared with in vitro digestion-Caco-2 cell culture method for the assessment of iron bioavailability in a processed and unprocessed complementary food for Tanzanian infants (6\u201312 months)","volume":"95","author":"Pynaert","year":"2006","journal-title":"Br J Nutr."},{"issue":"9","key":"10.1093\/ajcn\/nqab361_bib34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1753-4887.2010.00312.x","article-title":"Use of ferrous fumarate to fortify foods for infants and young children","volume":"68","author":"Hurrell","year":"2010","journal-title":"Nutr Rev."},{"issue":"6","key":"10.1093\/ajcn\/nqab361_bib35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1024\/0300-9831.75.6.395","article-title":"Methods and options in vitro dialyzability; benefits and limitations","volume":"75","author":"Sandberg","year":"2005","journal-title":"Int J Vitam Nutr Res."},{"issue":"6","key":"10.1093\/ajcn\/nqab361_bib36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1024\/0300-9831.75.6.371","article-title":"The usefulness of in vitro models to predict the bioavailability of iron and zinc: a consensus statement from the HarvestPlus expert consultation","volume":"75","author":"Fairweather-Tait","year":"2005","journal-title":"Int J Vitam Nutr Res."},{"issue":"6","key":"10.1093\/ajcn\/nqab361_bib37","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3945\/ajcn.116.142976","article-title":"The effect of lipids, a lipid-rich ready-to-use therapeutic food, or a phytase on iron absorption from maize-based meals fortified with micronutrient powders","volume":"105","author":"Monnard","year":"2017","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/ajcn\/nqab361_bib38","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br J Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqab361_bib39","first-page":"25","article-title":"Effect of phlebotomy and pH on iron absorption from the colon","volume":"11","author":"Chernelch","year":"1970","journal-title":"J Nucl Med."},{"issue":"9","key":"10.1093\/ajcn\/nqab361_bib40","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/0271-5317(96)00166-2","article-title":"Role of the proximal colon in mineral absorption in rats with and without ferropenic anemia","volume":"16","author":"Campos","year":"1996","journal-title":"Nutr Res."},{"issue":"4","key":"10.1093\/ajcn\/nqab361_bib41","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3945\/ajcn.116.145060","article-title":"Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: a stable-isotope study in Kenyan infants","volume":"106","author":"Paganini","year":"2017","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/ajcn\/nqab361_bib42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0016-5085(63)80031-1","article-title":"The absorption of iron from the human large intestine","volume":"44","author":"Ohkawara","year":"1963","journal-title":"Gastroenterology."},{"key":"10.1093\/ajcn\/nqab361_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.0954-6820.1960.tb15571.x","article-title":"Absorption of a single dose of iron in man","volume":"358","author":"Hallberg","year":"1960","journal-title":"Acta Med Scand Suppl."},{"key":"10.1093\/ajcn\/nqab361_bib44","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1182\/blood.V22.4.416.416","article-title":"The gastrointestinal tract and iron absorption","volume":"22","author":"Wheby","year":"1963","journal-title":"Blood."},{"key":"10.1093\/ajcn\/nqab361_bib45","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jn\/nxab007","article-title":"Consumption of a single dose of prebiotic galacto-oligosaccharides does not enhance iron absorption from micronutrient powders in Kenyan infants: a stable iron isotope Study","volume":"151","author":"Mikulic","year":"2021","journal-title":"J Nutr."},{"issue":"4-5","key":"10.1093\/ajcn\/nqab361_bib46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1024\/0300-9831\/a000029","article-title":"Intestinal iron absorption: regulation by dietary & systemic factors","volume":"80","author":"Sharp","year":"2010","journal-title":"Int J Vitam Nutr Res."},{"issue":"3","key":"10.1093\/ajcn\/nqab361_bib47","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/gast.2002.35353","article-title":"Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats","volume":"123","author":"Frazer","year":"2002","journal-title":"Gastroenterology."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522002106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522002106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ajcn\/advance-article-pdf\/doi\/10.1093\/ajcn\/nqab361\/41528726\/nqab361.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/115\/3\/949\/42696533\/nqab361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/115\/3\/949\/42696533\/nqab361.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T23:20:11Z","timestamp":1726010411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522002106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0002916522002106"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/nqab361","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinetics of iron absorption from ferrous fumarate with and without galacto-oligosaccharides determined from stable isotope appearance curves in women","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/nqab361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}