{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:20:01Z","timestamp":1772814001692,"version":"3.50.1"},"reference-count":11,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1093\/ajcn\/nqac095","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:15:08Z","timestamp":1649934908000},"page":"5-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Muddy water: Additional observational data cannot aid in determining whether there is a physiological interaction between low vitamin B12 and high folate in cognitive health"],"prefix":"10.1016","volume":"116","author":[{"given":"Regan L","family":"Bailey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J","family":"Stover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/nqac095_bib1","series-title":"Guiding principles for developing dietary reference intakes based on chronic disease.","year":"2017"},{"issue":"5","key":"10.1093\/ajcn\/nqac095_bib2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/ajcn\/nqaa259","article-title":"Knowledge gaps in understanding the metabolic and clinical effects of excess folates\/folic acid: A summary, and perspectives, from an NIH workshop","volume":"112","author":"Maruvada","year":"2020","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqac095_bib3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/nqac065","article-title":"Vitamin B-12 malabsorption and renal function are critical considerations in studies of folate and vitamin B-12 interactions in cognitive performance: NHANES 2011-2014","volume":"116","author":"Samson","year":"2022","journal-title":"Am J Clin Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqac095_bib4","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3945\/ajcn.2009.28671","article-title":"Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in 77 American seniors","volume":"91","author":"Morris","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqac095_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/ajcn\/85.1.193","article-title":"Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid 80 fortification","volume":"85","author":"Morris","year":"2007","journal-title":"Am J Clin Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqac095_bib6","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/ajcn\/nqaa239","article-title":"High folic acid or folate combined with low vitamin B-12 status: Potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES","volume":"112","author":"Bailey","year":"2020","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqac095_bib7","doi-asserted-by":"crossref","first-page":"afab259","DOI":"10.1093\/ageing\/afab259","article-title":"Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study","volume":"51","author":"Singh-Manoux","year":"2022","journal-title":"Age Ageing."},{"issue":"7","key":"10.1093\/ajcn\/nqac095_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/nutrit\/nuw015","article-title":"Safe use of high intakes of folic acid: Research challenges and paths forward","volume":"74","author":"Boyles","year":"2016","journal-title":"Nutr Rev."},{"issue":"3","key":"10.1093\/ajcn\/nqac095_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/advances\/nmy111","article-title":"Best practices for conducting observational research to assess the relation between nutrition and bone: An international working group summary","volume":"10","author":"Bailey","year":"2019","journal-title":"Adv Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqac095_bib10","first-page":"57","article-title":"Effect of obesity, age and gender on glomerular filtration rate measured in normal adults","volume":"79","author":"Gallet","year":"2021","journal-title":"Ann Biol Clin (Paris)."},{"issue":"11","key":"10.1093\/ajcn\/nqac095_bib11","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1890\/02-3114","article-title":"Confronting multicollinearity in ecological multiple regression","volume":"84","author":"Graham","year":"2003","journal-title":"Ecology."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652200003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652200003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/116\/1\/5\/45051225\/nqac095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/116\/1\/5\/45051225\/nqac095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T01:27:26Z","timestamp":1688174846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291652200003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S000291652200003X"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/nqac095","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muddy water: Additional observational data cannot aid in determining whether there is a physiological interaction between low vitamin B12 and high folate in cognitive health","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/nqac095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}