{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:16:55Z","timestamp":1791994615909,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1093\/ajcn\/nqac109","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T11:13:56Z","timestamp":1650539636000},"page":"599-607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Folate intake and incident chronic kidney disease: a 30-year follow-up study from young adulthood to midlife"],"prefix":"10.1016","volume":"116","author":[{"given":"Mengyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan Fan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7812-7982","authenticated-orcid":false,"given":"Xianhui","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10225","key":"10.1093\/ajcn\/nqac109_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet."},{"issue":"13","key":"10.1093\/ajcn\/nqac109_bib2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N Engl J Med."},{"issue":"5","key":"10.1093\/ajcn\/nqac109_bib3","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2015.230","article-title":"A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010","volume":"88","author":"Mills","year":"2015","journal-title":"Kidney Int."},{"issue":"3 Suppl 1","key":"10.1093\/ajcn\/nqac109_bib4","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2019.01.001","article-title":"US Renal Data System 2018 annual data report: epidemiology of kidney disease in the United States","volume":"73","author":"Saran","year":"2019","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"10.1093\/ajcn\/nqac109_bib5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0272-6386(04)00813-3","article-title":"Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study","volume":"44","author":"Ninomiya","year":"2004","journal-title":"Am J Kidney Dis."},{"issue":"1","key":"10.1093\/ajcn\/nqac109_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1161\/01.ATV.21.1.74","article-title":"Serum homocysteine levels are associated with the development of (micro)albuminuria: the Hoorn study","volume":"21","author":"Jager","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"10","key":"10.1093\/ajcn\/nqac109_bib7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.ejim.2014.10.014","article-title":"Elevated serum homocysteine is a predictor of accelerated decline in renal function and chronic kidney disease: a historical prospective study","volume":"25","author":"Levi","year":"2014","journal-title":"Eur J Intern Med."},{"issue":"1","key":"10.1093\/ajcn\/nqac109_bib8","doi-asserted-by":"crossref","first-page":"16268","DOI":"10.1038\/srep16268","article-title":"Hyperhomocysteinemia predicts renal function decline: a prospective study in hypertensive adults","volume":"5","author":"Xie","year":"2015","journal-title":"Sci Rep."},{"issue":"10","key":"10.1093\/ajcn\/nqac109_bib9","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1001\/jamainternmed.2016.4687","article-title":"Efficacy of folic acid therapy on the progression of chronic kidney disease","volume":"176","author":"Xu","year":"2016","journal-title":"JAMA Intern Med."},{"issue":"16","key":"10.1093\/ajcn\/nqac109_bib10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.2010.490","article-title":"Effect of B-vitamin therapy on progression of diabetic nephropathy","volume":"303","author":"House","year":"2010","journal-title":"JAMA."},{"issue":"10","key":"10.1093\/ajcn\/nqac109_bib11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA."},{"issue":"5","key":"10.1093\/ajcn\/nqac109_bib12","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3390\/nu13051517","article-title":"Dietary micronutrients and risk of chronic kidney disease: a cohort study with 12 year follow-up","volume":"13","author":"Lee","year":"2021","journal-title":"Nutrients."},{"issue":"4","key":"10.1093\/ajcn\/nqac109_bib13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/nu8040217","article-title":"Micronutrient intakes and incidence of chronic kidney disease in adults: Tehran Lipid and Glucose Study","volume":"8","author":"Farhadnejad","year":"2016","journal-title":"Nutrients."},{"issue":"11","key":"10.1093\/ajcn\/nqac109_bib14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0895-4356(88)90080-7","article-title":"CARDIA: study design, recruitment, and some characteristics of the examined subjects","volume":"41","author":"Friedman","year":"1988","journal-title":"J Clin Epidemiol."},{"issue":"9","key":"10.1093\/ajcn\/nqac109_bib15","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0002-8223(21)01299-2","article-title":"The CARDIA dietary history: development, implementation, and evaluation","volume":"91","author":"McDonald","year":"1991","journal-title":"J Am Diet Assoc."},{"issue":"1","key":"10.1093\/ajcn\/nqac109_bib16","first-page":"15","article-title":"A study of the reliability and comparative validity of the cardia dietary history","volume":"4","author":"Liu","year":"1994","journal-title":"Ethn Dis."},{"issue":"9","key":"10.1093\/ajcn\/nqac109_bib17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med."},{"issue":"7","key":"10.1093\/ajcn\/nqac109_bib18","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1017\/S0007114521001665","article-title":"Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011\u20132018","volume":"127","author":"Liu","year":"2022","journal-title":"Br J Nutr."},{"issue":"2","key":"10.1093\/ajcn\/nqac109_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/nu11020383","article-title":"Folic acid and vitamin B12 administration in CKD, why not?","volume":"11","author":"Capelli","year":"2019","journal-title":"Nutrients."},{"issue":"4","key":"10.1093\/ajcn\/nqac109_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1525-139X.2009.00579.x","article-title":"Hyperhomocysteinemia in uremia\u2014a red flag in a disrupted circuit","volume":"22","author":"Perna","year":"2009","journal-title":"Semin Dial."},{"issue":"8","key":"10.1093\/ajcn\/nqac109_bib21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/sj.ijo.0803265","article-title":"Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects","volume":"30","author":"Solini","year":"2006","journal-title":"Int J Obes (Lond)."},{"issue":"4","key":"10.1093\/ajcn\/nqac109_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10557-008-6109-8","article-title":"Effects of folic acid on cardiac myocyte apoptosis in rats with streptozotocin-induced diabetes mellitus","volume":"22","author":"Wu","year":"2008","journal-title":"Cardiovasc Drugs Ther."},{"issue":"3","key":"10.1093\/ajcn\/nqac109_bib23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/13880209.2015.1043561","article-title":"Synergistic protective effect of folic acid and vitamin B12 against nicotine-induced oxidative stress and apoptosis in pancreatic islets of the rat","volume":"54","author":"Bhattacharjee","year":"2016","journal-title":"Pharm Biol."},{"issue":"1\u20133","key":"10.1093\/ajcn\/nqac109_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2013.05.026","article-title":"Folic acid modulates eNOS activity via effects on posttranslational modifications and protein\u2013protein interactions","volume":"714","author":"Taylor","year":"2013","journal-title":"Eur J Pharmacol."},{"issue":"11","key":"10.1093\/ajcn\/nqac109_bib25","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.RES.86.11.1129","article-title":"Folic acid reverts dysfunction of endothelial nitric oxide synthase","volume":"86","author":"Stroes","year":"2000","journal-title":"Circ Res."},{"issue":"6","key":"10.1093\/ajcn\/nqac109_bib26","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.yjmcc.2009.07.025","article-title":"Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity","volume":"47","author":"Gao","year":"2009","journal-title":"J Mol Cell Cardiol."},{"issue":"9","key":"10.1093\/ajcn\/nqac109_bib27","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1093\/jn\/nxab155","article-title":"A plant-centered diet and markers of early chronic kidney disease during young to middle adulthood: findings from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort","volume":"151","author":"Choi","year":"2021","journal-title":"J Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqac109_bib28","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/oxfordjournals.aje.a009849","article-title":"Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements","volume":"149","author":"Hu","year":"1999","journal-title":"Am J Epidemiol."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522000648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522000648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ajcn\/advance-article-pdf\/doi\/10.1093\/ajcn\/nqac109\/43434814\/nqac109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/116\/2\/599\/45226132\/nqac109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcn\/article-pdf\/116\/2\/599\/45226132\/nqac109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T03:11:17Z","timestamp":1690859477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522000648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0002916522000648"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/nqac109","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folate intake and incident chronic kidney disease: a 30-year follow-up study from young adulthood to midlife","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/nqac109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}