{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:31:01Z","timestamp":1792729861634,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":1467,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA133595:MVG"],"award-info":[{"award-number":["R01 CA133595:MVG"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30 ES009089"],"award-info":[{"award-number":["P30 ES009089"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["T32 ES007322"],"award-info":[{"award-number":["T32 ES007322"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES010349"],"award-info":[{"award-number":["P42 ES010349"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01 ES017875:MVG"],"award-info":[{"award-number":["R01 ES017875:MVG"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["F31 ES029019:AKB"],"award-info":[{"award-number":["F31 ES029019:AKB"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1 TR001875"],"award-info":[{"award-number":["TL1 TR001875"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1093\/ajcn\/nqy148","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T15:14:46Z","timestamp":1529421286000},"page":"380-391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh"],"prefix":"10.1016","volume":"109","author":[{"given":"Anne K","family":"Bozack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan N","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Ilievski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Lomax-Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruque","family":"Parvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu B","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Shahriar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad N","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariqul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H","family":"Graziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V","family":"Gamble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/ajcn\/nqy148_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1289\/ehp.1205875","article-title":"The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem","volume":"121","author":"Naujokas","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib2","article-title":"Arsenic contamination of groundwater in Bangladesh. Vol. 1: Summary","author":"Kinniburgh","year":"2001","journal-title":"Arsenic contamination of groundwater in Bangladesh. Vol. 1: Summary"},{"key":"10.1093\/ajcn\/nqy148_bib3","unstructured":"World Health Organization. Arsenic [Internet]. WHO fact sheets.2012[cited 2016 May 16]. Available from: www.who.int\/mediacentre\/factsheets\/fs372\/en\/."},{"key":"10.1093\/ajcn\/nqy148_bib4","first-page":"3","article-title":"Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals","volume":"232","author":"Thomas","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1093\/ajcn\/nqy148_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/cr60115a003","article-title":"Biological methylation","volume":"36","author":"Challenger","year":"1945","journal-title":"Chem Rev"},{"key":"10.1093\/ajcn\/nqy148_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0013-9351(02)00081-6","article-title":"Variability in human metabolism of arsenic","volume":"92","author":"Loffredo","year":"2003","journal-title":"Environ Res"},{"key":"10.1093\/ajcn\/nqy148_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1999.8872","article-title":"Monomethylarsonous acid (MMAIII) is more toxic than arsenite in Chang human hepatocytes","volume":"163","author":"Petrick","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1093\/ajcn\/nqy148_bib8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jes.2016.10.004","article-title":"Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing","volume":"49","author":"Moe","year":"2016","journal-title":"J Environ Sci"},{"key":"10.1093\/ajcn\/nqy148_bib9","doi-asserted-by":"crossref","first-page":"7319","DOI":"10.3390\/ijerph110707319","article-title":"Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, northern China","volume":"11","author":"Zhang","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"10.1093\/ajcn\/nqy148_bib10","first-page":"1259","article-title":"Arsenic methylation capacity and skin cancer","volume":"9","author":"Yu","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/nqy148_bib11","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/ije\/dyt182","article-title":"Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction","volume":"42","author":"Pierce","year":"2013","journal-title":"Int J Epidemiol"},{"key":"10.1093\/ajcn\/nqy148_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.taap.2010.06.006","article-title":"Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina","volume":"247","author":"Steinmaus","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1093\/ajcn\/nqy148_bib13","first-page":"595307","article-title":"Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity","author":"Hall","year":"2012","journal-title":"J Toxicol"},{"key":"10.1093\/ajcn\/nqy148_bib14","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00726-011-0853-y","article-title":"The metabolic burden of creatine synthesis","volume":"40","author":"Brosnan","year":"2011","journal-title":"Amino Acids"},{"key":"10.1093\/ajcn\/nqy148_bib15","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1289\/ehp.8084","article-title":"Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh","volume":"113","author":"Gamble","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ajcn\/84.5.1093","article-title":"Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid\u2013supplementation trial in Bangladesh","volume":"84","author":"Gamble","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/nqy148_bib17","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/ajcn\/86.4.1202","article-title":"Folic acid supplementation lowers blood arsenic","volume":"86","author":"Gamble","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/nqy148_bib18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1289\/ehp.1409396","article-title":"Folic acid and creatine as therapeutic approaches to lower blood arsenic: a randomized controlled trial","volume":"12","author":"Peters","year":"2015","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib19","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1158\/1055-9965.EPI-06-0676","article-title":"Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh","volume":"16","author":"Ahsan","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/nqy148_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1289\/ehp.0800164","article-title":"Folate, cobalamin, cysteine, homocysteine, and arsenic metabolism among children in Bangladesh","volume":"117","author":"Hall","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib21","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1289\/ehp.1003393","article-title":"Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India","volume":"119","author":"Basu","year":"2011","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib22","doi-asserted-by":"crossref","first-page":"e113760","DOI":"10.1371\/journal.pone.0113760","article-title":"Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh","volume":"9","author":"Peters","year":"2014","journal-title":"PLoS One"},{"key":"10.1093\/ajcn\/nqy148_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/sj.jea.7500449","article-title":"Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation","volume":"16","author":"Ahsan","year":"2006","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"10.1093\/ajcn\/nqy148_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.scitotenv.2016.04.112","article-title":"Provision of well-water treatment units to 600 households in Bangladesh: a longitudinal analysis of urinary arsenic indicates fading utility","volume":"563","author":"Sanchez","year":"2016","journal-title":"Sci Total Environ"},{"key":"10.1093\/ajcn\/nqy148_bib25","unstructured":"Reuter W, Davidowski L, Neubauer K. Speciation of five arsenic compounds in urine by HPLC\/ICP-MS, PerkinElmer SCIEX. PerkinElmer Life and Analytical Sciences. Shelton, CT. 2003, www.perkinelmer.com\/PDFs\/Downloads\/app_speciationfivearseniccompounds.pdf."},{"key":"10.1093\/ajcn\/nqy148_bib26","first-page":"236","article-title":"Arsenic exposure in pregnancy: a population-based study in Matlab, Bangladesh","volume":"24","author":"Vahter","year":"2006","journal-title":"J Health Popul Nutr"},{"key":"10.1093\/ajcn\/nqy148_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/003685049908200104","article-title":"Methylation of inorganic arsenic in different mammalian species and population groups","volume":"82","author":"Vahter","year":"1999","journal-title":"Sci Prog"},{"key":"10.1093\/ajcn\/nqy148_bib28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1373\/clinchem.2004.032292","article-title":"Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations","volume":"50","author":"Miller","year":"2004","journal-title":"Clin Chem"},{"key":"10.1093\/ajcn\/nqy148_bib29","unstructured":"Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services. Syracuse Research Corporation. Toxicological profile for arsenic (update). Atlanta, GA; 2007, www.atsdr.cdc.gov\/toxprofiles\/tp2.pdf"},{"key":"10.1093\/ajcn\/nqy148_bib30","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria; 2015, www.R-project.org\/."},{"key":"10.1093\/ajcn\/nqy148_bib31","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.3945\/jn.115.216739","article-title":"Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, placebo-controlled trial","volume":"145","author":"Peters","year":"2015","journal-title":"J Nutr"},{"key":"10.1093\/ajcn\/nqy148_bib32","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/S0021-9258(18)61530-3","article-title":"Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium","volume":"262","author":"Jencks","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/nqy148_bib33","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0006-291X(85)80006-1","article-title":"Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism","volume":"127","author":"Wagner","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/ajcn\/nqy148_bib34","doi-asserted-by":"crossref","first-page":"22507","DOI":"10.1074\/jbc.R109.019273","article-title":"Glycine N-methyltransferase and regulation of S-adenosylmethionine levels","volume":"284","author":"Luka","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1093\/ajcn\/nqy148_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12918-015-0215-6","article-title":"Mathematical analysis of the regulation of competing methyltransferases","volume":"9","author":"Reed","year":"2015","journal-title":"BMC Syst Biol"},{"key":"10.1093\/ajcn\/nqy148_bib36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10545-010-9088-4","article-title":"Choline and betaine in health and disease","volume":"34","author":"Ueland","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"10.1093\/ajcn\/nqy148_bib37","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1289\/ehp.99107593","article-title":"Arsenic: health effects, mechanisms of actions, and research issues","volume":"107","author":"Abernathy","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1753-4887.2008.00043.x","article-title":"Can folate intake reduce arsenic toxicity?","volume":"66","author":"Kile","year":"2008","journal-title":"Nutr Rev"},{"key":"10.1093\/ajcn\/nqy148_bib39","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1158\/1055-9965.EPI-14-0059","article-title":"Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure","volume":"23","author":"Steinmaus","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/nqy148_bib40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1158\/1055-9965.EPI-12-1190","article-title":"Drinking water arsenic in northern Chile: high cancer risks 40 years after exposure cessation","volume":"22","author":"Steinmaus","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1093\/ajcn\/nqy148_bib41","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1289\/ehp.11872","article-title":"Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions","volume":"117","author":"Pilsner","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1093\/ajcn\/nqy148_bib42","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3945\/ajcn.113.059683","article-title":"Near-elimination of folate-deficiency anemia by mandatory folic acid fortification in older US adults: Reasons for Geographic and Racial Differences in Stroke study 2003\u20132007","volume":"98","author":"Odewole","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1093\/ajcn\/nqy148_bib43","first-page":"19","article-title":"Folate, vitamin B12 and homocysteine status in the post-folic acid fortification era in different subgroups of the Brazilian population attended to at a public health care center","volume":"14","author":"Barnab\u00e9","year":"2015","journal-title":"Nutr J BioMed Central"},{"key":"10.1093\/ajcn\/nqy148_bib44","unstructured":"Food Fortification Initiative. Defeating Anemia. 2015 Year In Review. Atlanta, USA; 2016, www.ffinetwork.org\/about\/stay_informed\/publications\/documents\/FFI2015Review.pdf."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652203101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000291652203101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/109\/2\/380\/28887501\/nqy148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T19:45:56Z","timestamp":1733946356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000291652203101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S000291652203101X"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/nqy148","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/nqy148","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}