{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:03:04Z","timestamp":1794002584358,"version":"4.8.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K020218\/1"],"award-info":[{"award-number":["MR\/K020218\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Clinical Nutrition"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1093\/ajcn\/nqz344","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T20:08:41Z","timestamp":1578600521000},"page":"739-748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study"],"prefix":"10.1016","volume":"111","author":[{"given":"Dafni","family":"Vasilopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-7354","authenticated-orcid":false,"given":"Oonagh","family":"Markey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty E","family":"Kliem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette C","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair S","family":"Grandison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim G","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I","family":"Givens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-9455","authenticated-orcid":false,"given":"Julie A","family":"Lovegrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/ajcn\/77.5.1146","article-title":"Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials","volume":"77","author":"Mensink","year":"2003","journal-title":"Am J Clin Nutr."},{"issue":"7","key":"10.1093\/ajcn\/nqz344_bib2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11883-016-0597-y","article-title":"Role of cis-monounsaturated fatty acids in the prevention of coronary heart disease","volume":"18","author":"Joris","year":"2016","journal-title":"Curr Atheroscler Rep."},{"key":"10.1093\/ajcn\/nqz344_bib3","series-title":"National Diet and Nutrition Survey. Results from Years 7\u20138 (combined) of the Rolling Programme (2014\/2015 to 2015\/2016).","author":"Roberts","year":"2018"},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S0954422416000160","article-title":"Dairy food products: good or bad for cardiometabolic disease?","volume":"29","author":"Lovegrove","year":"2016","journal-title":"Nutr Res Rev."},{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.116.151548","article-title":"Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps","volume":"105","author":"Thorning","year":"2017","journal-title":"Am J Clin Nutr."},{"issue":"4","key":"10.1093\/ajcn\/nqz344_bib6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/ajcn\/nqy146","article-title":"Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix\u2014a randomized controlled trial","volume":"108","author":"Feeney","year":"2018","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"10.1093\/ajcn\/nqz344_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3945\/ajcn.2009.27725","article-title":"Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease","volume":"91","author":"Siri-Tarino","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.7326\/M13-1788","article-title":"Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis","volume":"160","author":"Chowdhury","year":"2014","journal-title":"Ann Intern Med."},{"key":"10.1093\/ajcn\/nqz344_bib9","series-title":"Saturated fats and health: draft SACN report. [Internet].","year":"2018"},{"key":"10.1093\/ajcn\/nqz344_bib10","series-title":"Draft Guidelines on Saturated Fatty Acid and trans-fatty Acid Intake for Adults and Children [Internet].","year":"2018"},{"issue":"1","key":"10.1093\/ajcn\/nqz344_bib11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3945\/ajcn.114.097089","article-title":"Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure: results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study","volume":"102","author":"Vafeiadou","year":"2015","journal-title":"Am J Clin Nutr."},{"key":"10.1093\/ajcn\/nqz344_bib12","doi-asserted-by":"crossref","first-page":"h3978","DOI":"10.1136\/bmj.h3978","article-title":"Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies","volume":"351","author":"de Souza","year":"2015","journal-title":"BMJ."},{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib13","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3945\/ajcn.2008.27124","article-title":"Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies","volume":"89","author":"Jakobsen","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib14","first-page":"CD011737","article-title":"Reduction in saturated fat intake for cardiovascular disease","author":"Hooper","year":"2015","journal-title":"Cochrane Database Syst Rev."},{"key":"10.1093\/ajcn\/nqz344_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/1471-0307.12564","article-title":"Food chain approach to lowering the saturated fat of milk and dairy products","volume":"72","author":"Kliem","year":"2019","journal-title":"Int J Dairy Technol."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/nbu.12086","article-title":"Dairy and cardiovascular health: friend or foe?","volume":"39","author":"Markey","year":"2014","journal-title":"Nutr Bull."},{"issue":"23","key":"10.1093\/ajcn\/nqz344_bib17","doi-asserted-by":"crossref","first-page":"e1025","DOI":"10.1161\/CIR.0000000000000686","article-title":"Innovation to create a healthy and sustainable food system: a Science Advisory from the American Heart Association","volume":"139","author":"Anderson","year":"2019","journal-title":"Circulation."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S095442241200011X","article-title":"The impact of substituting SFA in dairy products with MUFA or PUFA on CVD risk: evidence from human intervention studies","volume":"25","author":"Livingstone","year":"2012","journal-title":"Nutr Res Rev."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10554-010-9616-1","article-title":"Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis","volume":"26","author":"Inaba","year":"2010","journal-title":"Int J Cardiovasc Imaging."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1161\/01.ATV.0000051384.43104.FC","article-title":"Endothelial dysfunction: a marker of atherosclerotic risk","volume":"23","author":"Bonetti","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"1","key":"10.1093\/ajcn\/nqz344_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12937-017-0249-2","article-title":"Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial","volume":"16","author":"Markey","year":"2017","journal-title":"Nutr J."},{"issue":"18","key":"10.1093\/ajcn\/nqz344_bib22","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation."},{"issue":"10","key":"10.1093\/ajcn\/nqz344_bib23","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.3168\/jds.2016-12057","article-title":"Consumer acceptance of dairy products with a saturated fatty acid\u2013reduced, monounsaturated fatty acid\u2013enriched content","volume":"100","author":"Markey","year":"2017","journal-title":"J Dairy Sci."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.ijo.0802547","article-title":"Revised QUICKI provides a strong surrogate estimate of insulin sensitivity when compared with the minimal model","volume":"28","author":"Brady","year":"2004","journal-title":"Int J Obes Relat Metab Disord."},{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic Biol Med."},{"key":"10.1093\/ajcn\/nqz344_bib27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11745-001-0785-6","article-title":"Serum cholesterol predictive equations with special emphasis on trans and saturated fatty acids. An analysis from designed controlled studies","volume":"36","author":"M\u00fcller","year":"2001","journal-title":"Lipids."},{"issue":"1","key":"10.1093\/ajcn\/nqz344_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/CIRCGENETICS.114.000216","article-title":"Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics","volume":"8","author":"Soininen","year":"2015","journal-title":"Circ Cardiovasc Genet."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol."},{"issue":"4","key":"10.1093\/ajcn\/nqz344_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc Dis."},{"issue":"7","key":"10.1093\/ajcn\/nqz344_bib31","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0026-0495(65)90004-1","article-title":"Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet","volume":"14","author":"Keys","year":"1965","journal-title":"Metabolism."},{"issue":"3","key":"10.1093\/ajcn\/nqz344_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0301-5629(02)00709-3","article-title":"Within-subject variability of flow-mediated vasodilation of the brachial artery in healthy men and women: implications for experimental studies","volume":"29","author":"De Roos","year":"2003","journal-title":"Ultrasound Med Biol."},{"issue":"4","key":"10.1093\/ajcn\/nqz344_bib33","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3945\/ajcn.115.113548","article-title":"Best (but oft-forgotten) practices: the multiple problems of multiplicity\u2014whether and how to correct for many statistical tests","volume":"102","author":"Streiner","year":"2015","journal-title":"Am J Clin Nutr."},{"issue":"S2","key":"10.1093\/ajcn\/nqz344_bib34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1017\/S0007114511003606","article-title":"Guidelines for the design, conduct and reporting of human intervention studies to evaluate the health benefits of foods","volume":"106","author":"Welch","year":"2011","journal-title":"Br J Nutr."},{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/ajcn\/17.5.281","article-title":"Quantitative effects of dietary fat on serum cholesterol in man","volume":"17","author":"Hegsted","year":"1965","journal-title":"Am J Clin Nutr."},{"issue":"8","key":"10.1093\/ajcn\/nqz344_bib36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.ATV.12.8.911","article-title":"Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials","volume":"12","author":"Mensink","year":"1992","journal-title":"Arterioscler Thromb."},{"issue":"7074","key":"10.1093\/ajcn\/nqz344_bib37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/bmj.314.7074.112","article-title":"Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies","volume":"314","author":"Clarke","year":"1997","journal-title":"BMJ."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib38","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/ajcn\/65.6.1747","article-title":"Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis","volume":"65","author":"Howell","year":"1997","journal-title":"Am J Clin Nutr."},{"issue":"9","key":"10.1093\/ajcn\/nqz344_bib39","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/jn\/135.9.2075","article-title":"Mechanisms by which dietary fatty acids modulate plasma lipids","volume":"135","author":"Fernandez","year":"2005","journal-title":"J Nutr."},{"issue":"1","key":"10.1093\/ajcn\/nqz344_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0021-9150(02)00306-4","article-title":"Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids","volume":"166","author":"Silva","year":"2003","journal-title":"Atherosclerosis."},{"issue":"2","key":"10.1093\/ajcn\/nqz344_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1194\/jlr.M500382-JLR200","article-title":"Saturated fat-induced changes in Sf 60\u2013400 particle composition reduces uptake of LDL by HepG2 cells","volume":"47","author":"Jackson","year":"2006","journal-title":"J Lipid Res."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib42","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11883-004-0086-6","article-title":"Diet and low-density lipoprotein particle size","volume":"6","author":"Desroches","year":"2004","journal-title":"Curr Atheroscler Rep."},{"issue":"12","key":"10.1093\/ajcn\/nqz344_bib43","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1017\/S0007114514002578","article-title":"Is there a linear relationship between the dose of ruminant trans-fatty acids and cardiovascular risk markers in healthy subjects: results from a systematic review and meta-regression of randomised clinical trials","volume":"112","author":"Gayet-Boyer","year":"2014","journal-title":"Br J Nutr."},{"issue":"6","key":"10.1093\/ajcn\/nqz344_bib44","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.ATV.0000163185.28245.a1","article-title":"Flow-mediated dilatation is impaired by a high\u2013saturated fat diet but not by a high-carbohydrate diet","volume":"25","author":"Keogh","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"12","key":"10.1093\/ajcn\/nqz344_bib45","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.7326\/0003-4819-134-12-200106190-00011","article-title":"Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men","volume":"134","author":"Fuentes","year":"2001","journal-title":"Ann Intern Med."},{"issue":"12","key":"10.1093\/ajcn\/nqz344_bib46","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.2337\/dc08-0924","article-title":"Differential effects of two isoenergetic meals rich in saturated or monounsaturated fat on endothelial function in subjects with type 2 diabetes","volume":"31","author":"Tentolouris","year":"2008","journal-title":"Diabetes Care."},{"issue":"12","key":"10.1093\/ajcn\/nqz344_bib47","first-page":"1299","article-title":"Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension","volume":"25","author":"Moreno-Luna","year":"2012","journal-title":"Am J Hypertens."},{"issue":"5","key":"10.1093\/ajcn\/nqz344_bib48","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.ATV.0000161048.72004.c2","article-title":"NO generation from nitrite and its role in vascular control","volume":"25","author":"Lundberg","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"1","key":"10.1093\/ajcn\/nqz344_bib49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S0007114508888708","article-title":"Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with \u03b1-linolenic acid on postprandial endothelial function in healthy men","volume":"100","author":"Fuentes","year":"2008","journal-title":"Br J Nutr."},{"key":"10.1093\/ajcn\/nqz344_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.appet.2017.04.015","article-title":"Convenience food with environmentally-sustainable attributes: a consumer perspective","volume":"116","author":"Stranieri","year":"2017","journal-title":"Appetite."}],"container-title":["The American Journal of Clinical Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522010607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002916522010607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/111\/4\/739\/32993855\/nqz344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ajcn\/article-pdf\/111\/4\/739\/32993855\/nqz344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:07:25Z","timestamp":1685362045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002916522010607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0002916522010607"],"URL":"https:\/\/doi.org\/10.1093\/ajcn\/nqz344","relation":{},"ISSN":["0002-9165"],"issn-type":[{"value":"0002-9165","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Clinical Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/ajcn\/nqz344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 American Society for Nutrition. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}