{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:00:02Z","timestamp":1781661602092,"version":"3.54.5"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Seattle Children\u2019s Mark Alan Bomgardner Endowment","award":["R24 DK099808"],"award-info":[{"award-number":["R24 DK099808"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Compare the morphologic, laboratory, and clinical features of asymptomatic and symptomatic Castleman disease in the pediatric population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed clinical records and histopathology of patients with Castleman disease from 2 pediatric institutions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 39 patients with pediatric Castleman disease, 37 had unicentric disease, all classified with the hyaline vascular variant of Castleman disease, 8 of which were clinically symptomatic. These 8 patients demonstrated abnormal laboratory findings, including microcytic anemia, elevated erythrocyte sedimentation rate and C-reactive protein, and hypoalbuminemia. In addition, histopathologic evaluation showed that the 8 symptomatic cases had more hyperplastic germinal centers, fewer atrophic or regressed germinal centers, fewer mantle zones containing multiple germinal centers, reduced \u201conion skinning\u201d of mantle zones, and fewer \u201clollipop\u201d formations compared with the asymptomatic cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This series of pediatric Castleman disease showed that lymph nodes from asymptomatic patients generally demonstrated the more classic hyaline vascular histology, whereas those with symptoms could lack or have only focal classic findings. As such, reactive lymph nodes with subtle Castleman-like features should prompt clinical correlation to ensure proper diagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa011","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T04:22:37Z","timestamp":1579148557000},"page":"821-832","source":"Crossref","is-referenced-by-count":13,"title":["Histologic and Laboratory Characteristics of Symptomatic and Asymptomatic Castleman Disease in the Pediatric Population"],"prefix":"10.1093","volume":"153","author":[{"given":"Karen M","family":"Chisholm","sequence":"first","affiliation":[{"name":"Department of Laboratories, Seattle Children\u2019s Hospital, Seattle, WA"},{"name":"Department of Laboratory Medicine, University of Washington, Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Fleming","sequence":"additional","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"2020082802120462600_CIT0001","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.blre.2017.11.005","article-title":"Clinical, laboratory and imaging findings in Castleman\u2019s disease\u2014the subtype decides","volume":"32","author":"Haap","year":"2018","journal-title":"Blood Rev."},{"key":"2020082802120462600_CIT0002","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s004310051166","article-title":"Paediatric Castleman disease: report of seven cases and review of the literature","volume":"158","author":"Parez","year":"1999","journal-title":"Eur J Pediatr."},{"key":"2020082802120462600_CIT0003","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/0194599813479931","article-title":"Castleman disease in the pediatric neck: a literature 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