{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:28:23Z","timestamp":1781098103801,"version":"3.54.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Oral Pathology of Federal University of Rio Grande do Norte"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-three published articles were included in our systematic review, corresponding to a total of 154 cases. SFT showed a slight female predilection (53.2%), and the cheek mucosa\/cheek, tongue, and palate were the most affected anatomical sites. The mean size of SFT in the oral cavity and maxillofacial region at diagnosis was 1.4 cm. Histologic features of malignancy by morphologic analysis (P\u2005&amp;lt;\u2005.001) were significantly associated with a larger tumor size. Surgical excision was the most frequent therapeutic modality. Recurrence and metastasis were uncommon findings in our sample.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Histologic features of malignancy can be important parameters of tumor behavior. Adequate surgical treatment and long-term follow-up are required for these cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa027","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T12:09:26Z","timestamp":1580904566000},"page":"15-22","source":"Crossref","is-referenced-by-count":13,"title":["Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor"],"prefix":"10.1093","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-7672","authenticated-orcid":false,"given":"Everton Freitas","family":"de Morais","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lder Domiciano Dantas","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katianne Soares","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-6601","authenticated-orcid":false,"given":"Gl\u00f3ria Maria","family":"de Fran\u00e7a","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ricka Janine Dantas","family":"da Silveira","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseana de Almeida","family":"Freitas","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"2020060811143030800_CIT0001","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","author":"Fletcher","year":"2013","edition":"4"},{"key":"2020060811143030800_CIT0002","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.oraloncology.2018.12.013","article-title":"Malignant extrapleural solitary fibrous tumor arising in the sublingual gland: a case report and review of literature","volume":"90","author":"Iorio","year":"2019","journal-title":"Oral Oncol"},{"key":"2020060811143030800_CIT0003","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.oooo.2015.11.001","article-title":"Clinicopathologic and immunohistochemical features of five new cases of solitary fibrous tumor of the oral cavity","volume":"121","author":"Carlos","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2020060811143030800_CIT0004","first-page":"4395049","article-title":"An unusual clinical presentation of solitary fibrous tumor in the oral cavity","volume":"2017","author":"de Morais","year":"2017","journal-title":"Case Rep Pathol"},{"key":"2020060811143030800_CIT0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/1066896915627485","article-title":"The current status of solitary fibrous tumor: diagnostic features, variants, and genetics","volume":"24","author":"Thway","year":"2016","journal-title":"Int J Surg Pathol."},{"key":"2020060811143030800_CIT0006","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12663-017-1053-4","article-title":"Solitary fibrous tumor of the tongue: an uncommon cause of obstructive sleep apnea","volume":"17","author":"Sorrenti","year":"2018","journal-title":"J Maxillofac Oral Surg"},{"key":"2020060811143030800_CIT0007","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.prp.2010.01.002","article-title":"Solitary fibrous tumor of the oral cavity with a predominant leiomyomatous-like pattern: a potential diagnostic pitfall","volume":"206","author":"Amico","year":"2010","journal-title":"Pathol Res Pract"},{"key":"2020060811143030800_CIT0008","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.anndiagpath.2018.01.004","article-title":"Extrapleural solitary fibrous tumor: a distinct entity from pleural solitary fibrous tumor. An update on clinical, molecular and diagnostic features","volume":"34","author":"Ronchi","year":"2018","journal-title":"Ann Diagn Pathol"},{"key":"2020060811143030800_CIT0009","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/modpathol.2013.164","article-title":"Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics","volume":"27","author":"Doyle","year":"2014","journal-title":"Mod Pathol"},{"key":"2020060811143030800_CIT0010","article-title":"Solitary fibrous tumors in the head and neck: comprehensive review and analysis","author":"Stanisce","journal-title":"Head Neck Pathol"},{"key":"2020060811143030800_CIT0011","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/his.12431","article-title":"Nuclear relocation of STAT6 reliably predicts NAB2-STAT6 fusion for the diagnosis of solitary fibrous tumour","volume":"65","author":"Koelsche","year":"2014","journal-title":"Histopathology"},{"key":"2020060811143030800_CIT0012","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12105-008-0073-2","article-title":"An aggressive solitary fibrous tumor with evidence of malignancy: a rare case report","volume":"2","author":"Vimi","year":"2008","journal-title":"Head Neck Pathol"},{"key":"2020060811143030800_CIT0013","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1245\/s10434-013-3242-9","article-title":"Prognosis of solitary fibrous tumors: a multicenter study","volume":"20","author":"van Houdt","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"2020060811143030800_CIT0014","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/S0046-8177(99)90169-7","article-title":"Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior","volume":"30","author":"Hasegawa","year":"1999","journal-title":"Hum Pathol"},{"key":"2020060811143030800_CIT0015","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/PAS.0000000000000940","article-title":"Solitary fibrous tumors of the head and neck: a multi-institutional clinicopathologic study","volume":"41","author":"Smith","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2020060811143030800_CIT0016","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tripleo.2010.01.023","article-title":"Solitary fibrous tumor of the head and neck","volume":"11","author":"Cox","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"2020060811143030800_CIT0017","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"2020060811143030800_CIT0018","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1177\/1043454209334415","article-title":"Diagnostic dilemma: solitary fibrous tumor or hemangiopericytoma of the submandibular region in a patient with multiple odontogenic keratocysts","volume":"26","author":"Garg","year":"2009","journal-title":"J Pediatr Oncol Nurs"},{"key":"2020060811143030800_CIT0019","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.joms.2007.08.019","article-title":"Solitary fibrous tumor of the oral cavity: case report and pathologic consideration","volume":"66","author":"Fusconi","year":"2008","journal-title":"J Oral Maxillofac Surg."},{"key":"2020060811143030800_CIT0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1440-1827.2003.01425.x","article-title":"Solitary fibrous tumor with malignant potential arising in sublingual gland","volume":"53","author":"Ogawa","year":"2003","journal-title":"Pathol Int"},{"key":"2020060811143030800_CIT0021","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0196-0709(03)00007-3","article-title":"Malignant solitary fibrous tumor of the tongue","volume":"24","author":"Shnayder","year":"2003","journal-title":"Am J Otolaryngol."},{"key":"2020060811143030800_CIT0022","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ajoms.2013.12.014","article-title":"Solitary fibrous tumor composing benign and malignant components in the floor of the mouth: a case report","volume":"27","author":"Nobusawa","year":"2015","journal-title":"J Oral Maxillofac Surg Med Pathol"},{"key":"2020060811143030800_CIT0023","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3892\/ol.2014.1977","article-title":"Solitary fibrous tumor of the soft palate: a report of two cases","volume":"7","author":"Li","year":"2014","journal-title":"Oncol Lett"},{"key":"2020060811143030800_CIT0024","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1007\/s11547-014-0409-9","article-title":"Solitary fibrous tumours in the extracranial head and neck region: correlation of CT and MR features with pathologic findings","volume":"119","author":"Liu","year":"2014","journal-title":"Radiol Med"},{"key":"2020060811143030800_CIT0025","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/his.12772","article-title":"Clinicopathological and genetic heterogeneity of the head and neck solitary fibrous tumours: a comparative histological, immunohistochemical and molecular study of 36 cases","volume":"68","author":"Kao","year":"2016","journal-title":"Histopathology."},{"key":"2020060811143030800_CIT0026","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.oraloncology.2008.10.013","article-title":"Malignant solitary fibrous tumors of the head and neck: a clinicopathological study of nine consecutive patients","volume":"45","author":"Yang","year":"2009","journal-title":"Oral Oncol"},{"key":"2020060811143030800_CIT0027","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/archotol.132.5.517","article-title":"Solitary fibrous tumors of the head and neck: a clinicopathologic and radiologic review","volume":"132","author":"Ganly","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2020060811143030800_CIT0028","first-page":"385","article-title":"Primary neoplasm of the pleura: a report of 5 cases","volume":"11","author":"Klemperer","year":"1931","journal-title":"Arch Pathol"},{"key":"2020060811143030800_CIT0029","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12105-009-0111-8","article-title":"Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases","volume":"3","author":"O\u2019Regan","year":"2009","journal-title":"Head Neck Pathol"},{"key":"2020060811143030800_CIT0030","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/00000478-200107000-00008","article-title":"Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases","volume":"25","author":"Alawi","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2020060811143030800_CIT0031","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1600-0714.2007.00568.x","article-title":"Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis","volume":"36","author":"Lo Muzio","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"2020060811143030800_CIT0032","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1017\/S0022215117001396","article-title":"Solitary fibrous tumour of the tongue: a series of four cases","volume":"131","author":"Dungarwalla","year":"2017","journal-title":"J Laryngol Otol"},{"key":"2020060811143030800_CIT0033","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1046\/j.1365-2559.1997.2400897.x","article-title":"Solitary fibrous tumour\u2014everywhere, and a diagnosis in vogue","volume":"31","author":"Chan","year":"1997","journal-title":"Histopathology"},{"key":"2020060811143030800_CIT0034","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1034\/j.1600-0714.2000.290407.x","article-title":"Solitary fibrous tumour of the oral cavity: clinicopathological and immunohistochemical characterization of three cases","volume":"29","author":"Lukinmaa","year":"2000","journal-title":"J Oral Pathol Med"},{"key":"2020060811143030800_CIT0035","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.joms.2003.08.038","article-title":"Solitary fibrous tumor of the palate: a case report and review of the literature","volume":"62","author":"Shimoyama","year":"2004","journal-title":"J Oral Maxillofac Surg."},{"key":"2020060811143030800_CIT0036","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/014556130608500713","article-title":"Solitary fibrous tumor of the floor of the mouth: case report and review of the literature","volume":"85","author":"Shine","year":"2006","journal-title":"Ear Nose Throat J."},{"key":"2020060811143030800_CIT0037","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.ajpath.2013.12.016","article-title":"Solitary fibrous tumors\/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features","volume":"184","author":"Barthelme\u00df","year":"2014","journal-title":"Am J Pathol."},{"key":"2020060811143030800_CIT0038","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jop.12953","article-title":"Solitary fibrous tumour of the oral cavity: an update","volume":"49","author":"Nunes","year":"2020","journal-title":"J Oral Pathol Med."},{"key":"2020060811143030800_CIT0039","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12105-015-0678-1","article-title":"Phosphaturic mesenchymal tumor involving the head and neck: a report of five cases with FGFR1 fluorescence in situ hybridization analysis","volume":"10","author":"Wasserman","year":"2016","journal-title":"Head Neck Pathol."},{"key":"2020060811143030800_CIT0040","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1245\/s10434-017-6092-z","article-title":"Size and location are the most important risk factors for malignant behavior in resected solitary fibrous tumors","volume":"24","author":"Gholami","year":"2017","journal-title":"Ann Surg Oncol."},{"key":"2020060811143030800_CIT0041","first-page":"100872","article-title":"A series of two cases of rare tumors: solitary fibrous tumor of the pleura","volume":"28","author":"Bukamur","year":"2019","journal-title":"Respir Med Case Rep."},{"key":"2020060811143030800_CIT0042","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1002\/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9","article-title":"Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature","volume":"47","author":"Briselli","year":"1981","journal-title":"Cancer."},{"key":"2020060811143030800_CIT0043","first-page":"169","article-title":"The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura","volume":"9","author":"Moran","year":"1992","journal-title":"Semin Diagn Pathol."},{"key":"2020060811143030800_CIT0044"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/154\/1\/15\/33368125\/aqaa027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/154\/1\/15\/33368125\/aqaa027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T15:16:23Z","timestamp":1591629383000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/154\/1\/15\/5782261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,5]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,3,5]]},"published-print":{"date-parts":[[2020,6,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqaa027","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,3,5]]}}}