{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:12:38Z","timestamp":1791850358261,"version":"4.3.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite\/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa062","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T11:09:08Z","timestamp":1586344148000},"page":"725-733","source":"Crossref","is-referenced-by-count":671,"title":["COVID-19 Autopsies, Oklahoma, USA"],"prefix":"10.1093","volume":"153","author":[{"given":"Lisa M","family":"Barton","sequence":"first","affiliation":[{"name":"Office of the Chief Medical Examiner, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J","family":"Duval","sequence":"first","affiliation":[{"name":"Office of the Chief Medical Examiner, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edana","family":"Stroberg","sequence":"first","affiliation":[{"name":"Office of the Chief Medical Examiner, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha","family":"Ghosh","sequence":"first","affiliation":[{"name":"Section of Thoracic Imaging, Imaging Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-2599","authenticated-orcid":false,"given":"Sanjay","family":"Mukhopadhyay","sequence":"first","affiliation":[{"name":"Department of Pathology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"2020050514075832600_CIT0001","author":"World Health Organization"},{"key":"2020050514075832600_CIT0002","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/ajcp\/aqaa029","article-title":"Three emerging coronaviruses in two decades","volume":"153","author":"Guarner","year":"2020","journal-title":"Am J Clin 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