{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:59:09Z","timestamp":1782255549795,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We report a rare case of B-lymphoblastic lymphoma (B-LBL) and low-grade follicular lymphoma (FL) identified concurrently in biopsies from different sites at the initial diagnosis in a 39-year-old man. The clonal relationship between the 2 histologic subtypes was investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A diagnosis of FL grade 1\/2 (low grade) was made by bone marrow (BM) biopsy. B-LBL was identified in biopsies from the testis and pancreas. Cytogenetic and molecular analyses were performed to investigate their clonal relationship.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Interphase fluorescence in situ hybridization analyses and G-banding karyotype analyses identified the BCL2-IGH and MYC-IGH translocation in tumor cells from both the BM and testis. The tumor cells from the BM and testis shared the same IGH VDJ usage and a high degree of somatic mutations. These findings suggest that acquisition of MYC gene rearrangement is a critical event for lymphoblastic transformation of FL. Of note, the presence of intraclonal diversity in the B-LBL sample further suggests an earlier or concurrent event of MYC translocation than the somatic IGH mutation in the germinal center and the dedifferentiation of lymphoma cells to a precursor stage of B-cell development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>B-lymphoblastic transformation of FL can occur with MYC gene rearrangement.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa126","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T11:09:40Z","timestamp":1593774580000},"page":"308-317","source":"Crossref","is-referenced-by-count":7,"title":["Simultaneous Discordant B-Lymphoblastic Lymphoma and Follicular Lymphoma"],"prefix":"10.1093","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5406-9300","authenticated-orcid":false,"given":"Ayumi","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyoshi","family":"Ikejiri","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumimasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riruke","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kurume University School of Medicine, Kurume, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Suzumiya","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-7614","authenticated-orcid":false,"given":"Ritsuro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shimane University Hospital, Izumo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"2021020409554027000_CIT0001","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin\u2019s lymphoma. 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