{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:33:40Z","timestamp":1780043620874,"version":"3.53.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Thyroid dysfunction in pregnancy is associated with increased risk of adverse outcomes to mother and child. Trimester-specific reference intervals for thyroid function tests are not routinely provided by clinical laboratories. In this study, we present first- and second-trimester-specific reference intervals in a US population for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total thyroxine (T4), and total triiodothyronine (T3) measured on Roche analyzers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used patient samples from first- and second-trimester prenatal screening. Samples were limited to singleton pregnancies and negative screening results for thyroid peroxidase and thyroglobulin antibodies. Analytes (TSH, FT4, T4, and T3) were measured on a Roche Modular e170 then verified on a Roche cobas e801.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The reference intervals established on the e170 and verified on the e801 for the first trimester were 0.16 to 2.82 mIU\/L for TSH, 12.0 to 18.5 pmol\/L for FT4, 62.8 to 177.9 nmol\/L for T4, and 1.5 to 3.4 nmol\/L for T3. The reference intervals for the second trimester were 0.40 to 3.62 mIU\/L for TSH, 10.2 to 16.6 pmol\/L for FT4, 66.6 to 176.0 nmol\/L for T4, and 1.56 to 3.6 nmol\/L for T3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first report of trimester-specific reference intervals for thyroid function tests on Roche analyzers in the United States, and it is consistent with worldwide reports.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa165","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T04:09:55Z","timestamp":1597291795000},"page":"776-780","source":"Crossref","is-referenced-by-count":10,"title":["First- and Second-Trimester Reference Intervals for Thyroid Function Testing in a US Population"],"prefix":"10.1093","volume":"155","author":[{"given":"Dustin R","family":"Bunch","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, CT"},{"name":"Yale School of Medicine, Yale University, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Firmender","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roa","family":"Harb","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, CT"},{"name":"Yale School of Medicine, Yale University, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe M","family":"El-Khoury","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale-New Haven Hospital, New Haven, CT"},{"name":"Yale School of Medicine, Yale University, New Haven, 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