{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:08:15Z","timestamp":1782742095576,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive thyroid fine-needle aspirates (patient age, \u226418 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 194,364 thyroid aspirates, 0.6% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3% and 59.0%, respectively. Malignant nodules (n = 179) accounted for 59.7% of resected nodules and 21.6% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa182","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T11:23:46Z","timestamp":1598613826000},"page":"680-689","source":"Crossref","is-referenced-by-count":18,"title":["Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population"],"prefix":"10.1093","volume":"155","author":[{"given":"Huy Gia","family":"Vuong","sequence":"first","affiliation":[{"name":"Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City"},{"name":"Stephenson Cancer Center, Oklahoma University Health Sciences Center, Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, 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