{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:22:03Z","timestamp":1775694123516,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>B-acute lymphoblastic leukemia (B-ALL) is a neoplasm of precursor lymphoid cells committed to the B-lineage. Expression of CD5 is rare in B-ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied the clinicopathologic, immunophenotypic, and molecular genetic features of 10 cases of B-ALL with aberrant CD5 expression, and compared with CD5\u2013B-ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B-ALL with aberrant CD5 expression is rare and predominantly affects men. Patients with CD5+ B-ALL had shorter median overall survival (21 vs 45 months, P = .0003). Expression of CD5 imposed a challenge in the differential diagnoses between B-ALL and other CD5+ B-cell lymphomas with blastic morphology. Dim CD20 and CD45, lack of surface immunoglobulin, expression of CD34 and TdT, negative immunostain for cyclin D1, and absence of t(11;14)(q13;q32) support a diagnosis of B-ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD5 expression is rare in B-ALL and associated with poor clinical outcome. CD5+ B-ALL represents a distinct entity that needs to be considered in the differential diagnoses of CD5+ B-cell lymphoproliferative disorders.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa269","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T12:09:34Z","timestamp":1608552574000},"page":"586-595","source":"Crossref","is-referenced-by-count":2,"title":["B-Lymphoblastic Leukemia With Aberrant CD5 Expression"],"prefix":"10.1093","volume":"156","author":[{"given":"Matthew T","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"},{"name":"Department of Pediatric Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David X","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"},{"name":"Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, and Tianjin\u2019s Clinical Research Center for Cancer , Tianjin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"},{"name":"Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, and Tianjin\u2019s Clinical Research Center for Cancer , Tianjin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"},{"name":"Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, and Tianjin\u2019s Clinical Research Center for Cancer , Tianjin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"},{"name":"Department of Pediatric Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine , Guangzhou , China"},{"name":"Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, and Tianjin\u2019s Clinical Research Center for Cancer , Tianjin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M James","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"2023021215113133300_CIT0001","first-page":"200","article-title":"B-lymphoblastic leukaemia\/lymphoma, not otherwise specified (NOS)","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Rev 4th ed","author":"Borowitz","year":"2017"},{"key":"2023021215113133300_CIT0002","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0167-5699(99)01476-0","article-title":"CD5 expression in human B-cell populations","volume":"20","author":"Youinou","year":"1999","journal-title":"Immunol Today."},{"key":"2023021215113133300_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00129039-200003000-00001","article-title":"Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel","volume":"8","author":"Chen","year":"2000","journal-title":"Appl Immunohistochem Mol Morphol."},{"key":"2023021215113133300_CIT0004","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/(SICI)1096-911X(199812)31:6<551::AID-MPO23>3.0.CO;2-E","article-title":"Brief report. CD19\/CD5 acute lymphoblastic leukemia","volume":"31","author":"Subir\u00e1","year":"1998","journal-title":"Med Pediatr Oncol."},{"key":"2023021215113133300_CIT0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2350\/06-03-0057.1","article-title":"CD5-positive B-cell acute lymphoblastic leukemia","volume":"10","author":"Peterson","year":"2007","journal-title":"Pediatr Dev Pathol."},{"key":"2023021215113133300_CIT0006","first-page":"310","article-title":"CD5-postive acute lymphoblastic leukemia","volume":"18","author":"Ahmed","year":"2008","journal-title":"J Col Phy Surg Pakistan."},{"key":"2023021215113133300_CIT0007","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1007\/s12288-014-0332-1","article-title":"Aberrant immunophenotypic expression of CD5 in a case of B acute lymphoblastic leukemia: a case report","volume":"39","author":"Mutreja","year":"2014","journal-title":"Indian J Hematol Blood Transfus."},{"key":"2023021215113133300_CIT0008","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s12288-014-0485-y","article-title":"CD5 positive B lymphoblastic leukemia: report of a case with review of literature","volume":"32","author":"Sreedharanunni","year":"2016","journal-title":"Indian J Hematol Blood Transfus."},{"key":"2023021215113133300_CIT0009","doi-asserted-by":"crossref","first-page":"e27484","DOI":"10.1002\/pbc.27484","article-title":"CD5 positive B-ALL, a uniquely aggressive subcategory of B-ALL? A case report and brief review of the literature","volume":"66","author":"Staley","year":"2019","journal-title":"Pediatr Blood Cancer."},{"key":"2023021215113133300_CIT0010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2141.2011.08870.x","article-title":"Aberrant T-cell antigen expression in B lymphoblastic leukaemia","volume":"155","author":"Hussein","year":"2011","journal-title":"Br J Haematol."},{"key":"2023021215113133300_CIT0011","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1309\/AJCP8G5RMTWUEMUU","article-title":"Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia","volume":"132","author":"Seegmiller","year":"2009","journal-title":"Am J Clin Pathol."},{"key":"2023021215113133300_CIT0012","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1309\/FDGWB5C2MYRYXH2E","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma associated with IgM paraprotein","volume":"123","author":"Yin","year":"2005","journal-title":"Am J Clin Pathol."},{"key":"2023021215113133300_CIT0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/modpathol.3800716","article-title":"Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma","volume":"20","author":"Yin","year":"2007","journal-title":"Mod Pathol."},{"key":"2023021215113133300_CIT0014","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/modpathol.3800026","article-title":"TaqMan RT-PCR assay coupled with capillary electrophoresis for quantification and identification of bcr-abl transcript type","volume":"17","author":"Luthra","year":"2004","journal-title":"Mod Pathol."},{"key":"2023021215113133300_CIT0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1182\/blood.V97.1.89","article-title":"Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia","volume":"97","author":"Meshinchi","year":"2001","journal-title":"Blood."},{"key":"2023021215113133300_CIT0016","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1182\/blood.V97.8.2434","article-title":"Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies","volume":"97","author":"Yamamoto","year":"2001","journal-title":"Blood."},{"key":"2023021215113133300_CIT0017","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jmoldx.2018.08.002","article-title":"Ultra-Rapid Reporting of GENomic Targets (URGENTseq): clinical next-generation sequencing results within 48 hours of sample collection","volume":"21","author":"Patel","year":"2019","journal-title":"J Mold Diagn."},{"key":"2023021215113133300_CIT0018","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/gcc.20732","article-title":"Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias","volume":"49","author":"Jones","year":"2010","journal-title":"Genes Chromosomes Cancer."},{"key":"2023021215113133300_CIT0019","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1074\/jbc.275.1.548","article-title":"The pseudo-immunoreceptor tyrosine-based activation motif of CD5 mediates its inhibitory action on B-cell receptor signaling","volume":"275","author":"Gary-Gouy","year":"2000","journal-title":"J Biol Chem."},{"key":"2023021215113133300_CIT0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.immuni.2016.04.003","article-title":"CD5 binds to interleukin-6 and induces a feed-forward loop with the transcription factor STAT3 in B cells to promote cancer","volume":"44","author":"Zhang","year":"2016","journal-title":"Immunity."},{"key":"2023021215113133300_CIT0021","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.humpath.2011.11.004","article-title":"CD5-positive mucosa-associated lymphoid tissue (MALT) lymphoma: a clinicopathologic study of 14 cases","volume":"43","author":"Jaso","year":"2012","journal-title":"Hum Pathol."},{"key":"2023021215113133300_CIT0022","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1309\/AJCPEMVXES72DUIF","article-title":"Clinicopathologic features of CD5-positive nodal marginal zone lymphoma","volume":"140","author":"Jaso","year":"2013","journal-title":"Am J Clin Pathol."},{"key":"2023021215113133300_CIT0023","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1309\/3G1XDX0DVHBNVKB4","article-title":"Immunophenotypic profile of lymphoplasmacytic lymphoma\/Waldenstr\u00f6m macroglobulinemia","volume":"124","author":"Konoplev","year":"2005","journal-title":"Am J Clin Pathol."},{"key":"2023021215113133300_CIT0024","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/modpathol.2015.42","article-title":"CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases","volume":"28","author":"Li","year":"2015","journal-title":"Mod Pathol."},{"key":"2023021215113133300_CIT0025","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3324\/haematol.12810","article-title":"De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients","volume":"93","author":"Yamaguchi","year":"2008","journal-title":"Haematologica."},{"key":"2023021215113133300_CIT0026","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3324\/haematol.2009.008474","article-title":"Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt\u2019s lymphoma","volume":"94","author":"Dictor","year":"2009","journal-title":"Haematologica."},{"key":"2023021215113133300_CIT0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0065-230X(08)60765-4","article-title":"Signal transduction through MAP kinase cascades","volume":"74","author":"Lewis","year":"1998","journal-title":"Adv Cancer Res."},{"key":"2023021215113133300_CIT0028","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MMBR.68.2.320-344.2004","article-title":"ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions","volume":"68","author":"Roux","year":"2004","journal-title":"Microbiol Mol Biol Rev."},{"key":"2023021215113133300_CIT0029","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jmoldx.2012.10.002","article-title":"Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma","volume":"15","author":"Greaves","year":"2013","journal-title":"J Mol Diagn."},{"key":"2023021215113133300_CIT0030","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1056\/NEJMoa1014209","article-title":"BRAF mutations in hairy-cell leukemia","volume":"364","author":"Tiacci","year":"2011","journal-title":"N Engl J Med."},{"key":"2023021215113133300_CIT0031","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.humpath.2015.12.029","article-title":"BRAF and MAP2K1 mutations in Langerhans cell histiocytosis: a study of 50 cases","volume":"52","author":"Alayed","year":"2016","journal-title":"Hum Pathol."},{"key":"2023021215113133300_CIT0032","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/modpathol.2017.55","article-title":"Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease","volume":"30","author":"Garces","year":"2017","journal-title":"Mod Pathol."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/4\/586\/49162296\/aqaa269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/4\/586\/49162296\/aqaa269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T09:30:43Z","timestamp":1698485443000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/156\/4\/586\/6210495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,5]]},"published-print":{"date-parts":[[2021,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqaa269","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,4,5]]}}}