{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:14:59Z","timestamp":1793502899414,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To review the new current diagnostic criteria of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) from the literature while highlighting distinguishing features. We provide comprehensive understanding of the importance of hemovigilance and its role in appropriately identifying and reporting these potentially fatal transfusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review of the English language literature was performed to analyze TACO and TRALI while providing further understanding of the rationale behind the historical underrecognition and underreporting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our review demonstrates the new 2018 and 2019 case definitions for TACO and TRALI, respectively. With more comprehensive diagnostic strategies, adverse transfusion events can be better recognized from mimicking events and underlying disease. In addition, there are mitigation strategies in place to help prevent complications of blood product transfusion, with emphasis on the prevention of TACO and TRALI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TACO and TRALI are potentially fatal adverse complications of blood transfusion. Both have been historically underrecognized and underreported due to poor defining criteria and overlapping symptomatology. Developing a thorough clinical understanding between these two entities can improve hemovigilance reporting and can contribute to risk factor identification and preventative measures.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqaa279","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T20:41:40Z","timestamp":1608583300000},"page":"529-539","source":"Crossref","is-referenced-by-count":40,"title":["Transfusion-Associated Circulatory Overload and Transfusion-Related Acute Lung Injury"],"prefix":"10.1093","volume":"156","author":[{"given":"Tayler A","family":"van den Akker","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Long Island School of Medicine , Mineola, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"2022092012442401000_CIT0001","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/vox.12447","article-title":"The International Haemovigilance Network Database for the Surveillance of Adverse Reactions and Events in Donors and Recipients of Blood Components: technical issues and results","volume":"111","author":"Politis","year":"2016","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0002","article-title":"Technical Manual. Bethesda, MD: AABB; 2020.","author":"CS"},{"key":"2022092012442401000_CIT0003","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/MOH.0b013e3282ef195a","article-title":"Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload","volume":"14","author":"Skeate","year":"2007","journal-title":"Curr Opin Hematol."},{"key":"2022092012442401000_CIT0004","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1182\/asheducation-2018.1.585","article-title":"TACO and TRALI: biology, risk factors, and prevention strategies","volume":"2018","author":"Roubinian","year":"2018","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"2022092012442401000_CIT0005","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1001\/jama.287.15.1968","article-title":"Transfusion-related acute lung injury: report of a clinical look-back investigation","volume":"287","author":"Kopko","year":"2002","journal-title":"JAMA."},{"key":"2022092012442401000_CIT0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.htct.2019.09.006","article-title":"Determining the true incidence of acute transfusion reactions: active surveillance at a specialized liver center","author":"Sahu","year":"2020;42:326-332","journal-title":"Hematol Transfus Cell Ther."},{"key":"2022092012442401000_CIT0007","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/trf.14359","article-title":"Analysis of pediatric adverse reactions to transfusions","volume":"58","author":"Vossoughi","year":"2018","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0008","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/trf.12827","article-title":"Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products","volume":"55","author":"Oakley","year":"2015","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0009","year":"2016"},{"key":"2022092012442401000_CIT0010","author":"Centers for Disease Control and Prevention.","year":"2018"},{"key":"2022092012442401000_CIT0011","author":"International Society of Blood Transfusion Working Party on Haemovigilance.","year":"2018"},{"key":"2022092012442401000_CIT0012","doi-asserted-by":"crossref","first-page":"e350","DOI":"10.1016\/S2352-3026(19)30080-8","article-title":"Revised international surveillance case definition of transfusion-associated circulatory overload: a classification agreement validation study","volume":"6","author":"Wiersum-Osselton","year":"2019","journal-title":"Lancet Haematol."},{"key":"2022092012442401000_CIT0013","author":"Popovsky","year":"2013"},{"key":"2022092012442401000_CIT0014","author":"Kevin","year":"2016"},{"key":"2022092012442401000_CIT0015","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood-2018-10-860809","article-title":"Transfusion-associated circulatory overload and transfusion-related acute lung injury","volume":"133","author":"Semple","year":"2019","journal-title":"Blood."},{"key":"2022092012442401000_CIT0016","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1111\/trf.15311","article-title":"A consensus redefinition of transfusion-related acute lung injury","volume":"59","author":"Vlaar","year":"2019","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0017","volume-title":"Robbins & Cotran Pathologic Basis of Disease.","author":"Kumar","edition":"9"},{"key":"2022092012442401000_CIT0018","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/vox.12473","article-title":"The association of fever with transfusion-associated circulatory overload","volume":"112","author":"Parmar","year":"2017","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0019","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1111\/j.1537-2995.2010.02748.x","article-title":"An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions","volume":"50","author":"Blumberg","year":"2010","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0020","first-page":"193","article-title":"Cardiogenic causes of fever","volume":"115","author":"Smid","year":"2018","journal-title":"Dtsch Arztebl Int."},{"key":"2022092012442401000_CIT0021","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/trf.13021","article-title":"Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions","volume":"55","author":"Roubinian","year":"2015","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0022","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/vox.12070","article-title":"Transfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during 2011","volume":"106","author":"Menis","year":"2014","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0023","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/CCM.0000000000003743","article-title":"Transfusion-associated circulatory overload in ICUs: a scoping review of incidence, risk factors, and outcomes","volume":"47","author":"De Cloedt","year":"2019","journal-title":"Crit Care Med."},{"key":"2022092012442401000_CIT0024","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.tmrv.2013.07.002","article-title":"A retrospective review of patient factors, transfusion practices, and outcomes in patients with transfusion-associated circulatory overload","volume":"27","author":"Lieberman","year":"2013","journal-title":"Transfus Med Rev."},{"key":"2022092012442401000_CIT0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/vox.12234","article-title":"Passive reporting greatly underestimates the rate of transfusion-associated circulatory overload after platelet transfusion","volume":"108","author":"Raval","year":"2015","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0026","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/CCM.0000000000002948","article-title":"Contemporary risk factors and outcomes of transfusion-associated circulatory overload","volume":"46","author":"Roubinian","year":"2018","journal-title":"Crit Care Med."},{"key":"2022092012442401000_CIT0027","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1111\/trf.13730","article-title":"Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication","volume":"56","author":"Hendrickson","year":"2016","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0028","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1182\/blood-2018-10-833988","article-title":"Noninfectious transfusion-associated adverse events and their mitigation strategies","volume":"133","author":"Goel","year":"2019","journal-title":"Blood."},{"key":"2022092012442401000_CIT0029","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmrv.2019.01.003","article-title":"Transfusion-associated circulatory overload: a clinical perspective","volume":"33","author":"Bosboom","year":"2019","journal-title":"Transfus Med Rev."},{"key":"2022092012442401000_CIT0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tmrv.2013.02.001","article-title":"The prevention of transfusion-associated circulatory overload","volume":"27","author":"Alam","year":"2013","journal-title":"Transfus Med Rev."},{"key":"2022092012442401000_CIT0031","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1111\/trf.15478","article-title":"Transfusion-associated circulatory overload risk mitigation: survey on hospital policies for compliance with AABB Standard 5.9.17","volume":"59","author":"Yazer","year":"2019","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0032","volume-title":"Standards for Blood Banks and Transfusion Services.","author":"AABB","year":"2018","edition":"31"},{"key":"2022092012442401000_CIT0033","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/000331978203300509","article-title":"Left ventricular filling pressures after rapid blood transfusion in cases of chronic severe anemia","volume":"33","author":"Gupta","year":"1982","journal-title":"Angiology."},{"key":"2022092012442401000_CIT0034","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/000331978303401102","article-title":"Haemodynamic changes following blood transfusion in cases of chronic severe anemia: increased safety with simultaneous furosemide administration","volume":"34","author":"Gupta","year":"1983","journal-title":"Angiology."},{"key":"2022092012442401000_CIT0035","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jpeds.2011.05.022","article-title":"Furosemide for packed red cell transfusion in preterm infants: a randomized controlled trial","volume":"159","author":"Balegar V","year":"2011","journal-title":"J Pediatr."},{"key":"2022092012442401000_CIT0036","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/trf.15270","article-title":"Can furosemide prevent transfusion-associated circulatory overload? Results of a pilot, double-blind, randomized controlled trial","volume":"59","author":"Pendergrast","year":"2019","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0037","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tmrv.2004.10.001","article-title":"Proceedings of a consensus conference: towards an understanding of TRALI","volume":"19","author":"Goldman","year":"2005","journal-title":"Transfus Med Rev."},{"key":"2022092012442401000_CIT0038","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/j.0041-1132.2004.04347.x","article-title":"Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel","volume":"44","author":"Kleinman","year":"2004","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0039","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin definition","volume":"307","author":"Ranieri","year":"2012","journal-title":"JAMA."},{"key":"2022092012442401000_CIT0040","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1537-2995.1985.25686071434.x","article-title":"Diagnostic and pathogenetic considerations in transfusion-related acute lung injury","volume":"25","author":"Popovsky","year":"1985","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1423-0410.2005.00648.x","article-title":"Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion","volume":"89","author":"Bux","year":"2005","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0042","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1097\/01.CCM.0000214287.58444.2D","article-title":"Animal models of transfusion-related acute lung injury","volume":"34","author":"Looney","year":"2006","journal-title":"Crit Care Med."},{"key":"2022092012442401000_CIT0043","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2005-04-1744","article-title":"Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model","volume":"107","author":"Sachs","year":"2006","journal-title":"Blood."},{"key":"2022092012442401000_CIT0044","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood-2008-09-177857","article-title":"Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model","volume":"113","author":"Kelher","year":"2009","journal-title":"Blood."},{"key":"2022092012442401000_CIT0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tmrv.2010.08.002","article-title":"Experimental models of transfusion-related acute lung injury","volume":"25","author":"Gilliss","year":"2011","journal-title":"Transfus Med Rev."},{"key":"2022092012442401000_CIT0046","first-page":"585","article-title":"TACO and TRALI: biology, risk factors, and prevention studies. Hematology Am Soc Hematol Educ Program","author":"Roubinian","year":"2018"},{"key":"2022092012442401000_CIT0047","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1182\/blood-2015-09-672592","article-title":"C-reactive protein enhances murine antibody-mediated transfusion-related acute lung injury","volume":"126","author":"Kapur","year":"2015","journal-title":"Blood."},{"key":"2022092012442401000_CIT0048","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1378\/chest.126.1.249","article-title":"Transfusion-related acute lung injury: a review","volume":"126","author":"Looney","year":"2004","journal-title":"Chest."},{"key":"2022092012442401000_CIT0049","doi-asserted-by":"crossref","first-page":"C1592","DOI":"10.1152\/ajpcell.00540.2001","article-title":"A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release","volume":"283","author":"Wyman","year":"2002","journal-title":"Am J Physiol Cell Physiol."},{"key":"2022092012442401000_CIT0050","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/vox.12573","article-title":"Transfusion-related acute lung injury risk mitigation: an update","volume":"112","author":"Otrock","year":"2017","journal-title":"Vox Sang."},{"key":"2022092012442401000_CIT0051","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CCM.0000000000000675","article-title":"Male-predominant plasma transfusion strategy for preventing transfusion-related acute lung injury: a systematic review","volume":"43","author":"Schmickl","year":"2015","journal-title":"Crit Care Med."},{"key":"2022092012442401000_CIT0052","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/trf.12816","article-title":"Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis","volume":"55","author":"M\u00fcller","year":"2015","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0053","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1537-2995.2005.00587.x","article-title":"White blood cell-reactive antibodies are undetectable in solvent\/detergent plasma","volume":"45","author":"Sachs","year":"2005","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0054","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2370.2004.00481.x","article-title":"Presence of HLA antibodies in single-donor-derived fresh frozen plasma compared with pooled, solvent detergent-treated plasma (Octaplas)","volume":"31","author":"Sinnott","year":"2004","journal-title":"Eur J Immunogenet."},{"key":"2022092012442401000_CIT0055","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000487513","article-title":"Platelet additive solutions: a review of the latest developments and their clinical implications","volume":"45","author":"van der Meer","year":"2018","journal-title":"Transfus Med Hemother."},{"key":"2022092012442401000_CIT0056","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood-2002-03-0958","article-title":"Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors","volume":"101","author":"Silliman","year":"2003","journal-title":"Blood."},{"key":"2022092012442401000_CIT0057","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/trf.15068","article-title":"Transfusion-associated circulatory overload\u2014a systematic review of diagnostic biomarkers","volume":"59","author":"Klanderman","year":"2019","journal-title":"Transfusion."},{"key":"2022092012442401000_CIT0058","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1537-2995.2008.01941.x","article-title":"The accuracy of natriuretic peptides (BNP and NTproBNP) in the differentiation between transfusion related acute lung injury (TRALI) and transfusion related circulatory overload (TACO) in the critically ill","volume":"49","journal-title":"Transfusion."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/4\/529\/45937616\/aqaa279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/4\/529\/45937616\/aqaa279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:12:12Z","timestamp":1697404332000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/156\/4\/529\/6210494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,5]]},"published-print":{"date-parts":[[2021,9,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqaa279","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,4,5]]}}}