{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:25:11Z","timestamp":1785684311045,"version":"3.56.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate SATB2 expression and prognostic implications in a large cohort of thoracic neuroendocrine tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Surgical pathology files (1995-2017) and an institutional thymic epithelial tumor database (2010-2020) were searched for resected neuroendocrine tumors. Cases were stained with SATB2 (clone EP281). Percent SATB2-positive tumor cells and expression intensity were scored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the lung, SATB2 was expressed in 5% or more of tumor cells in 29 (74.4%) of 39 small cell carcinomas and 9 (22.5%) of 40 atypical and 26 (40.6%) of 64 typical carcinoid tumors. SATB2 percent tumor cell expression and intensity were higher in small cell carcinomas than in carcinoid tumors (both P\u2005&amp;lt;\u2005.001, respectively). After adjusting for tumor subtype, SATB2 expression did not correlate with outcome. In the thymus, four (100%) of four atypical carcinoid tumors and one large cell neuroendocrine carcinoma but no small cell carcinoma (n\u2005=\u20052) expressed SATB2 in 5% or more of tumor cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SATB2 (clone EP281) is expressed in a large subset of pulmonary and thymic neuroendocrine tumors and therefore does not appear to be a useful marker to identify the origin of neuroendocrine tumors. Validation studies are needed, specifically including thymic neuroendocrine tumors, as the expression pattern might be different in those tumors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab038","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T12:10:56Z","timestamp":1613823056000},"page":"853-865","source":"Crossref","is-referenced-by-count":5,"title":["SATB2 Is Expressed in a Subset of Pulmonary and Thymic Neuroendocrine Tumors"],"prefix":"10.1093","volume":"156","author":[{"given":"Julie A","family":"Vrana","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Boland","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7560-2346","authenticated-orcid":false,"given":"Simone B S P","family":"Terra","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research , Rochester, MN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9483-6903","authenticated-orcid":false,"given":"Aaron S","family":"Mansfield","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology , Rochester, MN , 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