{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:50:44Z","timestamp":1760043044412,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Follicular hyperplasias (FHs) with light chain\u2013restricted (LCR) plasmacytoid\/plasma cells (PCs) within germinal centers (GCs) based on immunohistochemistry (IHC)\/in situ hybridization (ISH) can potentially lead to diagnostic error. This study aims to better characterize such cases, including their clinical implications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>LC expression by IHC\/ISH was quantitatively assessed in GCs of 17 FHs with LCRGCs. BCL2, CD10, BCL6, BCL2, immunoglobulin (Ig) heavy chains, IgG4, and Epstein-Barr encoding region stains were performed. In total, 8 cases had polymerase chain reaction (PCR)\u2013based clonality studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All cases showed FH, including 4 with progressively transformed GCs (PTGCs); 0.8% to 52% (median, 21%) of the GCs were LCR; 13 of 17 had both \u03ba- and \u03bb-LCRGCs, and 4 of 17 had only \u03ba-LCRGCs; 7 of 16 had prominent intrafollicular IgG4-positive cells. One case demonstrated BCL2-positive cells in focal LCRGCs but lacked BCL2 rearrangement. B-cell monoclonality was demonstrated in 3 of 8 cases (only after microdissection). Seven patients had autoimmune disorders, and 1 had had a transplant. Three patients had a history of lymphoma, 1 developed lymphoma, and 1 developed lymphomatoid granulomatosis subsequently.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FHs with LCRGC by IHC\/ISH are typically not associated with the development of lymphoma, even though they can express BCL2 and show monoclonality by PCR. They may be associated with increased intrafollicular IgG4-positive cells, PTGC, and autoimmunity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab043","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:14:08Z","timestamp":1614773648000},"page":"871-885","source":"Crossref","is-referenced-by-count":6,"title":["Light Chain\u2013Restricted Plasmacytoid Cells in Hyperplastic Germinal CentersA Clinicopathologic Investigation"],"prefix":"10.1093","volume":"156","author":[{"given":"Xuan J","family":"Wang","sequence":"first","affiliation":[{"name":"Divisions of Hematopathology, University of Pittsburgh Medical Center , Pittsburgh, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-2409","authenticated-orcid":false,"given":"Erika M","family":"Moore","sequence":"additional","affiliation":[{"name":"Divisions of Hematopathology, University of Pittsburgh Medical Center , Pittsburgh, PA , USA"},{"name":"Department of Pathology, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-3329","authenticated-orcid":false,"given":"Steven H","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"Divisions of Hematopathology, University of Pittsburgh Medical Center , Pittsburgh, PA , USA"},{"name":"Department of Pathology, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-0132","authenticated-orcid":false,"given":"Nidhi","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Divisions of Hematopathology, University of Pittsburgh Medical Center , Pittsburgh, PA , USA"},{"name":"Department of Pathology, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA"},{"name":"Molecular and Genomics Pathology, University of Pittsburgh Medical Center , Pittsburgh, PA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"2023021116312428300_CIT0001","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1182\/blood-2018-11-852442","article-title":"Kaposi sarcoma-associated herpesvirus\/human herpesvirus 8-associated lymphoproliferative disorders","volume":"133","author":"Oksenhendler","year":"2019","journal-title":"Blood."},{"key":"2023021116312428300_CIT0002","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood-2004-01-0385","article-title":"Atypical marginal zone hyperplasia of mucosa-associated lymphoid tissue: a reactive condition of childhood showing immunoglobulin lambda light-chain restriction","volume":"104","author":"Attygalle","year":"2004","journal-title":"Blood."},{"key":"2023021116312428300_CIT0003","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/his.12511","article-title":"Childhood florid follicular hyperplasia with immunoglobulin light-chain restriction in the gastrointestinal tract","volume":"65","author":"Martinez-Lopez","year":"2014","journal-title":"Histopathology."},{"key":"2023021116312428300_CIT0004","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/path.4524","article-title":"Paediatric nodal marginal zone B-cell lymphadenopathy of the neck: a Haemophilus influenzae-driven immune disorder?","volume":"236","author":"Kluin","year":"2015","journal-title":"J Pathol."},{"key":"2023021116312428300_CIT0005","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1365-2559.2008.02965.x","article-title":"Light-chain-restricted germinal centres in reactive lymphadenitis: report of eight cases","volume":"52","author":"Nam-Cha","year":"2008","journal-title":"Histopathology."},{"key":"2023021116312428300_CIT0006","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/AJCP\/AQX067","article-title":"Atypical IgG4+ plasmacytic proliferations and lymphomas: characterization of 11 cases","volume":"148","author":"Bledsoe","year":"2017","journal-title":"Am J Clin Pathol."},{"key":"2023021116312428300_CIT0007","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/PAS.0000000000000269","article-title":"Plasma cell (Zoon) balanitis: another inflammatory disorder that can be rich in IgG4+ plasma cells","volume":"38","author":"Aggarwal","year":"2014","journal-title":"Am J Surg Pathol."},{"key":"2023021116312428300_CIT0008","first-page":"658","article-title":"Cytogenetic studies in neoplastic hematologic disorders","volume-title":"Clinical Laboratory Medicine. 2nd ed. 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