{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:27:28Z","timestamp":1777973248824,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Pathologic evaluation of nonneoplastic renal parenchyma in nephrectomy specimens is important for identifying chronic kidney disease and diabetic nephropathy, but increasing utilization of partial nephrectomies has led to less-sampled nonneoplastic parenchyma. The sampled tissue is often composed predominantly of the peritumoral atrophic band (PAB) directly adjacent to the tumor. We sought to determine the characteristics of the PAB and whether it could be used to reliably assess kidney pathology, including diabetic nephropathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated 59 radical nephrectomies to determine the PAB characteristics, whether the PAB is representative of distant nonneoplastic parenchyma, and if diabetic nephropathy could be reliably detected in the PAB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mesangial sclerosis was detected within the PAB in 100% of cases with mesangial sclerosis in the distant parenchyma. Eighty percent had a history of diabetes. The PAB exhibited increased glomerular sclerosis (51% vs 13%, P\u2005&amp;lt;\u2005.001) and interstitial fibrosis and tubular atrophy (83% vs 13%, P\u2005&amp;lt;\u2005.001) compared with distant parenchyma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Diabetic nephropathy can be reliably detected in the PAB, which is important in partial nephrectomies or renal mass biopsies without ample distant renal parenchyma. The degree of glomerular and tubulointerstitial scarring within the PAB does not reflect the overall degree of chronic kidney disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab048","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T12:09:33Z","timestamp":1615032573000},"page":"913-919","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of the Peritumoral Atrophic Band and Nonneoplastic Renal Parenchyma in Radical Nephrectomy Specimens"],"prefix":"10.1093","volume":"156","author":[{"given":"Carl","family":"Dernell","sequence":"first","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavna","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Medical College of Wisconsin , Milwaukee, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A","family":"Iczkowski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-6133","authenticated-orcid":false,"given":"Alexander J","family":"Gallan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College of Wisconsin , Milwaukee, WI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"2023021116312578300_CIT0001","author":"American Cancer Society."},{"key":"2023021116312578300_CIT0002","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.4065\/75.12.1236","article-title":"Matched comparison of radical nephrectomy vs nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney","volume":"75","author":"Lau","year":"2000","journal-title":"Mayo Clin Proc."},{"key":"2023021116312578300_CIT0003","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/PAS.0b013e31804ca63e","article-title":"Non-neoplastic renal diseases are often unrecognized in adult tumor nephrectomy specimens: a review of 246 cases","volume":"31","author":"Henriksen","year":"2007","journal-title":"Am J Surg Pathol."},{"key":"2023021116312578300_CIT0004","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.5858\/133.7.1012","article-title":"Nonneoplastic kidney diseases in adult tumor nephrectomy and nephroureterectomy specimens: common, harmful, yet underappreciated","volume":"133","author":"Henriksen","year":"2009","journal-title":"Arch Pathol Lab Med."},{"key":"2023021116312578300_CIT0005","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.pas.0000194296.74097.87","article-title":"Evaluation of the nonneoplastic pathology in tumor nephrectomy specimens: predicting the risk of progressive renal failure","volume":"30","author":"Bijol","year":"2006","journal-title":"Am J Surg Pathol."},{"key":"2023021116312578300_CIT0006","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00345-011-0720-1","article-title":"Pathologic evaluation of non-neoplastic renal parenchyma in partial nephrectomy specimens","volume":"31","author":"Garcia-Roig","year":"2013","journal-title":"World J Urol."},{"key":"2023021116312578300_CIT0007","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/PAP.0b013e3181e3c02d","article-title":"The non-neoplastic kidney in tumor nephrectomy specimens: what can it show and what is important?","volume":"17","author":"Bonsib","year":"2010","journal-title":"Adv Anat Pathol."},{"key":"2023021116312578300_CIT0008","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1186\/s12885-017-3849-5","article-title":"Pathologic analysis of non-neoplastic parenchyma in renal cell carcinoma: a comprehensive observation in radical nephrectomy specimens","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Cancer."},{"key":"2023021116312578300_CIT0009","first-page":"49","article-title":"Diagnosis of non-neoplastic renal diseases in renal mass biopsies","volume":"3","author":"Tjota","year":"2019","journal-title":"J Onconephrol."},{"key":"2023021116312578300_CIT0010","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N Engl J Med."},{"key":"2023021116312578300_CIT0011","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N Engl J Med."},{"key":"2023021116312578300_CIT0012","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa011303","article-title":"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes","volume":"345","author":"Lewis","year":"2001","journal-title":"N Engl J Med."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/5\/913\/49161211\/aqab048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/5\/913\/49161211\/aqab048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T16:32:13Z","timestamp":1676133133000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/156\/5\/913\/6291036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,6,2]]},"published-print":{"date-parts":[[2021,10,13]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqab048","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,6,2]]}}}