{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:09:26Z","timestamp":1787832566690,"version":"build-2784847793"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to test the hypothesis that in retroperitoneal dedifferentiated liposarcoma (DDLS) the presence of the dedifferentiated (DD) component at the resection margin is associated with adverse outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively searched the archive for primary resections of retroperitoneal DDLS performed at our institution between 1990 and 2017. Slides were rereviewed for diagnosis, F\u00e9d\u00e9ration Nationale des Centres de Lutte Contre le Cancer grade, myogenic differentiation, and the presence of the well-differentiated (WD) or DD component at the resection margin. The medical records were reviewed for patient age, sex, tumor size, tumor focality, adjuvant\/neoadjuvant therapy, local recurrence, distant metastases, local recurrence-free survival (LRFS), overall survival (OS), and follow-up duration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The presence of the DD component at the resection margin was associated with worse LRFS compared with cases without the DD component at the margin (P = .002). However, OS was not significantly affected (P = .11).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LRFS is significantly shorter in cases with the DD component at the margin compared with cases without DD tumor at the margin, while there is no association with OS. We recommend reporting the presence or absence of DD tumor at the margin in retroperitoneal DDLS, as it adds meaningful prognostic information.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab051","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T04:13:25Z","timestamp":1615436005000},"page":"920-925","source":"Crossref","is-referenced-by-count":20,"title":["Retroperitoneal Dedifferentiated Liposarcoma"],"prefix":"10.1093","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5214-4813","authenticated-orcid":false,"given":"Carina A","family":"Dehner","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University , St Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S","family":"Hagemann","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University , St Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S A","family":"Chrisinger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University , St Louis, MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"2023021116313385800_CIT0001","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00000478-197912000-00004","article-title":"Liposarcoma: a study of 55 cases with a reassessment of its classification","volume":"3","author":"Evans","year":"1979","journal-title":"Am J Surg Pathol."},{"key":"2023021116313385800_CIT0002","article-title":"Dedifferentiated liposarcoma. In:","volume-title":"WHO Classification of Soft Tissue and Bone Tumours.","author":"Dei Tos","year":"2019"},{"key":"2023021116313385800_CIT0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.pas.0000213406.95440.7a","article-title":"Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years","volume":"31","author":"Evans","year":"2007","journal-title":"Am J Surg Pathol."},{"key":"2023021116313385800_CIT0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.path.2018.11.001","article-title":"Update on lipomatous tumors with emphasis on emerging entities, unusual anatomic sites, and variant histologic patterns","volume":"12","author":"Chrisinger","year":"2019","journal-title":"Surg Pathol Clin."},{"key":"2023021116313385800_CIT0005","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/01.MP.0000056983.78547.77","article-title":"Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma","volume":"16","author":"Coindre","year":"2003","journal-title":"Mod Pathol."},{"key":"2023021116313385800_CIT0006","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00428-009-0815-x","article-title":"Well-differentiated and dedifferentiated liposarcomas","volume":"456","author":"Coindre","year":"2010","journal-title":"Virchows Arch."},{"key":"2023021116313385800_CIT0007","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.cell.2017.10.014","article-title":"Comprehensive and integrated genomic characterization of adult soft tissue sarcomas","volume":"171","year":"2017","journal-title":"Cell"},{"key":"2023021116313385800_CIT0008","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41379-018-0171-y","article-title":"Amplification of DNA damage-inducible transcript 3 (DDIT3) is associated with myxoid liposarcoma-like morphology and homologous lipoblastic differentiation in dedifferentiated liposarcoma","volume":"32","author":"Mantilla","year":"2019","journal-title":"Mod Pathol."},{"key":"2023021116313385800_CIT0009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00000478-199703000-00002","article-title":"Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation","volume":"21","author":"Henricks","year":"1997","journal-title":"Am J Surg Pathol."},{"key":"2023021116313385800_CIT0010","first-page":"113","article-title":"Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation","volume":"10","author":"Elgar","year":"1997","journal-title":"Mod Pathol."},{"key":"2023021116313385800_CIT0011","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/1097-0142(19860715)58:2<306::AID-CNCR2820580216>3.0.CO;2-7","article-title":"Reproducibility of a histopathologic grading system for adult soft tissue sarcoma","volume":"58","author":"Coindre","year":"1986","journal-title":"Cancer."},{"key":"2023021116313385800_CIT0012","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1200\/JCO.1997.15.1.350","article-title":"Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma","volume":"15","author":"Guillou","year":"1997","journal-title":"J Clin Oncol."},{"key":"2023021116313385800_CIT0013","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.5858\/2006-130-1448-GOSTSR","article-title":"Grading of soft tissue sarcomas: review and update","volume":"130","author":"Coindre","year":"2006","journal-title":"Arch Pathol Lab Med."},{"key":"2023021116313385800_CIT0014","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1200\/JCO.2012.44.3747","article-title":"Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets","volume":"31","author":"Gronchi","year":"2013","journal-title":"J Clin Oncol."},{"key":"2023021116313385800_CIT0015","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/cncr.29931","article-title":"External validation of a multi-institutional retroperitoneal sarcoma nomogram","volume":"122","author":"Raut","year":"2016","journal-title":"Cancer."},{"key":"2023021116313385800_CIT0016","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jamcollsurg.2013.10.009","article-title":"Predictors of outcomes in patients with primary retroperitoneal dedifferentiated liposarcoma undergoing surgery","volume":"218","author":"Keung","year":"2014","journal-title":"J Am Coll Surg."},{"key":"2023021116313385800_CIT0017","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/PAS.0000000000000366","article-title":"Myogenic differentiation and histologic grading are major prognostic determinants in retroperitoneal liposarcoma","volume":"39","author":"Gronchi","year":"2015","journal-title":"Am J Surg Pathol."},{"key":"2023021116313385800_CIT0018","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2559.2012.04348.x","article-title":"Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases","volume":"62","author":"Sioletic","year":"2013","journal-title":"Histopathology."},{"key":"2023021116313385800_CIT0019","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/PAS.0b013e3181e5dc49","article-title":"Dedifferentiated liposarcoma with \u201chomologous\u201d lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria","volume":"34","author":"Mari\u00f1o-Enr\u00edquez","year":"2010","journal-title":"Am J Surg Pathol."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/5\/920\/49161228\/aqab051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/156\/5\/920\/49161228\/aqab051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T16:32:41Z","timestamp":1676133161000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/156\/5\/920\/6298557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,6,14]]},"published-print":{"date-parts":[[2021,10,13]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqab051","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,6,14]]}}}