{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:20:31Z","timestamp":1790252431300,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) differs from classic Hodgkin lymphoma (CHL) in terms of clinicopathologic features, including Epstein-Barr virus (EBV) association. CHL geographic variability is well known, with higher frequencies of mixed-cellularity subtype and EBV positivity in low\/middle-income countries (LMICs), but there are few well-characterized series of NLPHL from LMICs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We detail clinicopathologic findings of 21 NLPHL cases received in consultation from Kenya and summarize reports of NLPHL with EBV testing published since 2000.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Median age of consultation cases was 36 years, and male\/female ratio was 3.2. All cases involved peripheral lymph nodes and showed at least some B-cell\u2013rich nodular immunoarchitecture, with prominent extranodular lymphocyte-predominant (LP) cells and T-cell\u2013rich variant patterns most commonly seen. LP cells expressed pan\u2013B-cell markers, including strong OCT2; lacked CD30 and CD15 expression in most cases; and were in a background of expanded\/disrupted follicular dendritic cell meshworks and increased T-follicular helper cells. LP cells were EBV negative in 18 cases. Historical cases showed a low rate of EBV positivity with no significant difference between LMICs and high-income countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Unlike CHL, NLPHL shows few geographic differences in terms of clinicopathologic features and EBV association. These findings have implications for diagnosis, prognostication, and treatment of patients with NLPHL in LMICs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab113","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:25:19Z","timestamp":1622114719000},"page":"231-243","source":"Crossref","is-referenced-by-count":10,"title":["Geographic Variability of Nodular Lymphocyte-Predominant Hodgkin Lymphoma"],"prefix":"10.1093","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-0577","authenticated-orcid":false,"given":"Daniel","family":"Xia","sequence":"first","affiliation":[{"name":"Division of Hematopathology and Transfusion Medicine, University Health Network , Toronto , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Sayed","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahir","family":"Moloo","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel M","family":"Gakinya","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Mutuiri","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wawire","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-3979","authenticated-orcid":false,"given":"Patricia","family":"Okiro","sequence":"additional","affiliation":[{"name":"Aga Khan University Hospital , Nairobi , Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"Courville","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Virginia , Charlottesville, VA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P","family":"Hasserjian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School , Boston, MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6307-4854","authenticated-orcid":false,"given":"Aliyah R","family":"Sohani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School , Boston, MA , 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