{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:05:40Z","timestamp":1770282340406,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA006973"],"award-info":[{"award-number":["P30 CA006973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Ocular amyloidoma is a rare disorder characterized by deposition of insoluble proteinaceous fibrils in the extracellular space of the ocular adnexa. This study details the clinicopathologic features and proteomic characteristics of periocular amyloid deposition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Specimens (1991-2020) were retrieved and reviewed. All available H&amp;E slides and special stains were reviewed. Proteomic analysis was performed using immunohistochemistry (IHC) for IgG, IgG4, IgA, IgD, IgM, CD20, CD3, CD138, and \u03ba\/\u03bb, as well as chromatography-electrospray tandem mass spectrometry on formalin-fixed, paraffin-embedded tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 14 patients (7 men, 7 women). The depositions involved eyelid (n = 3), conjunctiva (n = 8), and orbit (n = 3). All patients were adults with a median age at diagnosis of 56 (range, 39-88) years. The deposits were predominantly \u03bb light chain restricted (n = 6) and mixed light chains (n = 2), and one case was \u03ba predominant. Two of the cases with a mixture of \u03ba and \u03bb light chains had an excess of transthyretin by mass spectrometry. Four of the cases did not have adequate material for proteomic subtyping.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Amyloidomas involving ocular adnexa contain a variety of amyloid-related and immunoglobulin-associated peptides. The \u03bb light chain predominates as in other body sites, but mixed patterns and rarely \u03ba light chain restriction may be encountered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqab161","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:21:22Z","timestamp":1631100082000},"page":"620-627","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathologic and Proteomic Analysis of Amyloidomas Involving the Ocular Surface and Adnexa"],"prefix":"10.1093","volume":"157","author":[{"given":"Pouya","family":"Jamshidi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Northshore University Health System , Evanston, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Levi","sequence":"additional","affiliation":[{"name":"National Institutes of Health , Bethesda, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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