{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:11:09Z","timestamp":1782393069763,"version":"3.54.5"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Tissue carryovers are contaminants of surgical pathology cases in which extraneous tissue is incorporated into tissue blocks. Carryovers occur most frequently at the grossing or embedding stations, but little is published about them. We sought to analyze their transmission during transit to the histology lab.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cassettes of friable donor tissue were mixed with cassettes of spongy recipient tissue in formalin-filled containers and agitated by shipment via pneumatic tube. The tissue cassettes were processed, embedded as blocks, and cut as usual. Liquid samples were prepared from the submission containers as well as from workstation submission containers and histology tissue processor waste.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A high rate of contamination (14.9%) was observed under these artificial conditions. Friable donor tissue, including urothelium and colorectal adenocarcinoma, were promiscuous contaminants, as were placental villi. Fluid from submission containers showed viable tumor cells and fragments, which were also present in workstation submission containers and in tissue processor waste fluid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study implicates liquid transport media as a possible avenue of contamination during submission and transportation of tissue cassettes for histologic processing. Attention should be given to the friability of submitted tissue and physical agitation of the cassettes in transit. Such contaminants may be present in the fluid in tissue submission bins and in tissue processor fluid.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqac014","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T20:10:10Z","timestamp":1642191010000},"page":"96-104","source":"Crossref","is-referenced-by-count":9,"title":["Tissue Contamination During Transportation of Formalin-Fixed, Paraffin-Embedded Blocks"],"prefix":"10.1093","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-2158","authenticated-orcid":false,"given":"Timothy","family":"Carll","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fuja","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Antic","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Lastra","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"McGary","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-4709","authenticated-orcid":false,"given":"Peter","family":"Pytel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"2023060113160777900_CIT0001","first-page":"1009","article-title":"Extraneous tissue in surgical pathology: a College of American Pathologists Q-Probes study of 275 laboratories","volume":"120","author":"Gephardt","year":"1996","journal-title":"Arch Pathol Lab Med."},{"key":"2023060113160777900_CIT0002","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1177\/1066896920913110","article-title":"A practical approach to investigating cross contaminants in the anatomical pathology laboratory","volume":"28","author":"Hodgson","year":"2020","journal-title":"Int J Surg Pathol."},{"key":"2023060113160777900_CIT0003","doi-asserted-by":"crossref","first-page":"973","DOI":"10.5858\/133.6.973","article-title":"Tissue floaters and contaminants in the histology laboratory","volume":"133","author":"Platt","year":"2009","journal-title":"Arch Pathol Lab Med."},{"key":"2023060113160777900_CIT0004","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1179\/2046023612Y.0000000013","article-title":"Measurement of stainer bath contamination and evaluation of common mitigation strategies","volume":"35","author":"Cahill","year":"2012","journal-title":"J Histotechnol."},{"key":"2023060113160777900_CIT0005","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.humpath.2006.08.015","article-title":"Diagnosis of ectopic tissue versus contamination by genetic fingerprinting in a routine surgical pathology specimen","volume":"38","author":"Venditti","year":"2007","journal-title":"Hum Pathol."},{"key":"2023060113160777900_CIT0006","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1309\/AJCPLNO4PFVZVA4P","article-title":"The changing spectrum of DNA-based specimen provenance testing in surgical pathology","volume":"135","author":"Pfeifer","year":"2011","journal-title":"Am J Clin Pathol."},{"key":"2023060113160777900_CIT0007","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/PAS.0b013e31826247a2","article-title":"Identification of tissue contamination by polymorphic deletion probe fluorescence in situ hybridization","volume":"36","author":"Chiang","year":"2012","journal-title":"Am J Surg Pathol."},{"key":"2023060113160777900_CIT0008","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PAP.0b013e31817bf596","article-title":"Identifying cross contaminants and specimen mix-ups in surgical pathology","volume":"15","author":"Hunt","year":"2008","journal-title":"Adv Anat Pathol."},{"key":"2023060113160777900_CIT0009","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1309\/AJCP4FFSBPHAU8IU","article-title":"Extraneous tissue: a potential source for diagnostic error in surgical pathology","volume":"136","author":"Layfield","year":"2011","journal-title":"Am J Clin Pathol."}],"container-title":["American Journal of Clinical 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