{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:37:41Z","timestamp":1791005861016,"version":"4.1.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006732","name":"New York University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institutional Review Board","award":["s21-00733"],"award-info":[{"award-number":["s21-00733"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Data on Papanicolaou (Pap) tests with atypical glandular cells (AGCs) with concurrent squamous cell abnormalities (AGC + Sq) are limited. We evaluated histologic outcomes and the role of high-risk human papillomavirus (HR-HPV) testing in this setting compared with AGCs without concurrent squamous cell abnormalities (AGC-alone).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used a retrospective cohort of patients with Pap test diagnoses of AGC + Sq and AGC-alone between October 2013 and August 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 287 Pap tests from 278 patients. The HR-HPV test was positive in 55% of AGC + Sq cases and 14% of AGC-alone cases (P &amp;lt; .0001). Most AGC + Sq cases displayed squamous lesions (41.5%) or were benign (41.5%) on histology, whereas AGC-alone cases were predominantly benign (72%) or extracervical neoplasms (18%). AGC + Sq cases showed higher rates of significant histologic lesions (P = .0001), which were associated with positive HR-HPV status (P = .0012). In AGC-alone cases, HR-HPV status was associated with significant histology only in patients 50 years of age or younger. In both groups, 20% or more of HR-HPV\u2013negative patients harbored significant lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AGC + Sq represents a distinct group of patients. HR-HPV testing and patient age provide useful information in the evaluation of AGC, but triage based on HR-HPV testing is not recommended because of the potential for missing significant lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqac097","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T13:50:23Z","timestamp":1661349023000},"page":"626-631","source":"Crossref","is-referenced-by-count":6,"title":["Role of High-Risk HPV Testing in Papanicolaou Tests With Atypical Glandular Cells With and Without Concurrent Squamous Cell Abnormalities"],"prefix":"10.1093","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-9783","authenticated-orcid":false,"given":"Lawrence H","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology, NYU Langone Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam N","family":"Koloori","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Langone Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar C","family":"Brandler","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Langone Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Simsir","sequence":"additional","affiliation":[{"name":"Department of Pathology, NYU Langone Medical Center , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"2022110309064778700_CIT0001","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/cncy.21724","article-title":"Clinical significance of atypical glandular cells in Pap tests: an analysis of more than 3000 cases at a large academic women\u2019s center","volume":"124","author":"Pradhan","year":"2016","journal-title":"Cancer Cytopathol."},{"key":"2022110309064778700_CIT0002","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejogrb.2019.06.006","article-title":"Glandular cell abnormalities in cervical cytology: what has changed in this decade and what has not?","volume":"240","author":"Kumar","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"2022110309064778700_CIT0003","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/cncr.11826","article-title":"Glandular cell atypia on Papanicolaou smears: interobserver variability in the diagnosis and prediction of cell of origin","volume":"99","author":"Simsir","year":"2003","journal-title":"Cancer."},{"key":"2022110309064778700_CIT0004","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/dc.24268","article-title":"Can we predict histological outcome of distinctive cohorts of patients with glandular cell abnormalities on ThinPrep Papanicolaou testing based on human papillomavirus status, age, and associated squamous abnormalities?","volume":"47","author":"Harbhajanka","year":"2019","journal-title":"Diagn Cytopathol."},{"key":"2022110309064778700_CIT0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000330872","article-title":"ThinPrep pap test. Accuracy for glandular disease","volume":"43","author":"Ashfaq","year":"1999","journal-title":"Acta Cytol."},{"key":"2022110309064778700_CIT0006","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/LGT.0000000000000525","article-title":"2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors","volume":"24","author":"Perkins","year":"2020","journal-title":"J Low Genit Tract Dis."},{"key":"2022110309064778700_CIT0007","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5858\/2008-0755-OAR1.1","article-title":"Clinical utility of adjunctive high-risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells","volume":"134","author":"Zhao","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"2022110309064778700_CIT0008","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/ajcp\/aqaa265","article-title":"High-risk human papillomavirus testing, genotyping, and histopathologic follow-up in women with abnormal glandular cells on Papanicolaou tests","volume":"156","author":"Zuo","year":"2021","journal-title":"Am J Clin Pathol."},{"key":"2022110309064778700_CIT0009","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000490230","article-title":"Significance of high-risk human papillomavirus testing for atypical glandular cells on cervical cytology","volume":"62","author":"Komatsu","year":"2018","journal-title":"Acta Cytol."},{"key":"2022110309064778700_CIT0010","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/cncy.21448","article-title":"Papanicolaou tests with coexisting squamous and glandular abnormalities","volume":"122","author":"Khor","year":"2014","journal-title":"Cancer Cytopathol."},{"key":"2022110309064778700_CIT0011","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-11074-5","volume-title":"The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory 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histopathologic diagnoses of cervical glandular neoplasia","volume":"140","author":"Zhao","year":"2013","journal-title":"Am J Clin Pathol."},{"key":"2022110309064778700_CIT0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/dc.20999","article-title":"Differentiating between endocervical glandular neoplasia and high grade squamous intraepithelial lesions in endocervical crypts: cytological features in ThinPrep and SurePath cervical cytology samples","volume":"37","author":"Thiryayi","year":"2009","journal-title":"Diagn Cytopathol."},{"key":"2022110309064778700_CIT0016","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ijc.29424","article-title":"High-risk HPV testing in the management of atypical glandular cells: a systematic review and meta-analysis","volume":"138","author":"Verdoodt","year":"2016","journal-title":"Int J Cancer."}],"container-title":["American Journal of Clinical 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