{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T18:19:57Z","timestamp":1784744397953,"version":"3.55.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Epstein-Barr virus (EBV)\u2013associated lymphoproliferative disorders (LPDs) encompass a group of well-defined entities of B-, T-, and natural killer (NK)\u2013cell derivation. The diagnosis of these disorders is challenging because of clinical and morphologic features that may overlap with other benign and malignant EBV+\u2005lymphoproliferations. This review describes our approach to the diagnosis of EBV-associated LPDs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two cases are presented that illustrate how we diagnose EBV-associated LPDs. The first case represents a systemic EBV+\u2005T-cell lymphoma of childhood and the second case an EBV+\u2005mucocutaneous ulcer. The clinicopathologic features that help distinguish these entities from biological and morphologic mimickers are emphasized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The accurate diagnosis of EBV-associated LPDs requires the incorporation of histologic and immunophenotypic features, the assessment of the EBV latency program, and, most important, complete clinical findings. Clonality analysis is not helpful in distinguishing benign from malignant EBV+\u2005LPDs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The better understanding of EBV-associated LPDs has resulted in the recognition of well-defined entities of B-, T-, and NK-cell derivation and consequently improvement of their treatment with curative intent. It is critical to distinguish benign from malignant EBV+\u2005LPDs to avoid overtreatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqac105","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T19:39:46Z","timestamp":1665430786000},"page":"14-33","source":"Crossref","is-referenced-by-count":18,"title":["How I Diagnose EBV-Positive B- and T-Cell Lymphoproliferative Disorders"],"prefix":"10.1093","volume":"159","author":[{"given":"Stefan D","family":"Dojcinov","sequence":"first","affiliation":[{"name":"All Wales Lymphoma Panel, Swansea Bay University Health Board and Swansea University , Swansea, Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5365","authenticated-orcid":false,"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology and Comprehensive Cancer Center T\u00fcbingen, University Hospital T\u00fcbingen, Eberhard-Karls-University, T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"2023010721540066200_CIT0001","article-title":"EBV-positive lymphoproliferations of B- T- and NK-cell derivation in non-immunocompromised hosts","volume":"7:28","author":"Dojcinov","year":"2018","journal-title":"Pathogens."},{"key":"2023010721540066200_CIT0002","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41379-019-0415-5","article-title":"Mutational profile and EBV strains of extranodal NK\/T-cell lymphoma, nasal type in Latin America","volume":"33","author":"Montes-Mojarro","year":"2020","journal-title":"Mod Pathol."},{"key":"2023010721540066200_CIT0003","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/10428194.2019.1699080","article-title":"Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international 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