{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:57:21Z","timestamp":1775829441811,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXFH033"],"award-info":[{"award-number":["2019HXFH033"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2021HXFH027"],"award-info":[{"award-number":["2021HXFH027"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore the approach to the diagnosis of malignant serous effusion (SE) caused by angioimmunoblastic T-cell lymphoma (AITL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical, cytomorphologic, immunophenotypic, and molecular features of 6 patients were summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinically, SE caused by AITL was predominant in middle-aged and older male patients with multiple SEs and lymphadenopathy. Cytomorphology showed small to medium-sized, irregular lymphocytes with clear cytoplasm and mixed with various inflammatory cells and apoptosis. Hodgkin\/Reed-Sternberg\u2013like cells were detected in 2 of 6 cases. Furthermore, 2 patterns of cytomorphology were described for the first time. Flow cytometry revealed abnormal T-cell populations with loss of surface CD3 (3\/4 cases) and CD7 (3\/4 cases). In addition, B-cell populations lacking surface immunoglobulin (Ig) were identified in 2 of 4 cases. Immunocytochemical staining revealed expression of at least 2 T follicular helper markers. Epstein-Barr virus\u2013encoded RNA (EBER)\u2013positive cells were demonstrated in 4 of 5 cases. Clonal T-cell receptor \u03b3 chain rearrangement was detected in 6 cases, and 3 of them had concomitant clonal immunoglobulin gene rearrangement. Moreover, 2 cases revealed discrepant findings regarding IgH\/Ig\u03ba rearrangements in cytohistologic correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study broadens the morphologic spectrum of malignant SE caused by AITL and provides diagnostic criteria in routine practice.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqac170","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T13:59:15Z","timestamp":1678197555000},"page":"379-394","source":"Crossref","is-referenced-by-count":4,"title":["Angioimmunoblastic T-Cell Lymphoma Diagnosed From Serous Effusion by Integration of Cytologic Features and Ancillary Studies"],"prefix":"10.1093","volume":"159","author":[{"given":"Jinnan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Core Facilities of West China Hospital, Sichuan University , Chengdu , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, West China Hospital, Sichuan University , Chengdu , 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