{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:59:14Z","timestamp":1793656754032,"version":"4.5.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:00:00Z","timestamp":1679097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Amyloid light chain (AL)-\u03ba and AL-\u03bb share common histopathologic changes; however, the potential difference in clinical manifestations, histologic findings, and clinical significance between the 2 subtypes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective study, 94 kidney biopsies for AL amyloidosis were evaluated using the composite scarring injury score (CSIS) and amyloid score (AS). Results were then compared between AL-\u03ba and AL-\u03bb.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparing AS and CSIS between AL-\u03ba and AL-\u03bb, the AS was significantly higher in AL-\u03ba than in AL-\u03bb, with 2 components of AS (capillary wall and vascular amyloid) scoring higher in AL-\u03ba than in AL-\u03bb, while mesangial and interstitial ASs were similar in the 2 cohorts. In addition, the proportion of periodic acid\u2013Schiff strong-staining amyloid in AL-\u03ba was markedly higher than in AL-\u03bb. There was no significant difference in CSIS and its components between the 2 subtypes of AL amyloidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, AL-\u03ba presents with higher serum creatinine and a higher AS score than AL-\u03bb at biopsy, which may indicate a worse prognosis and be an important reference for clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad017","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T15:55:05Z","timestamp":1675007705000},"page":"144-149","source":"Crossref","is-referenced-by-count":12,"title":["Differences between \u03ba and \u03bb light chain amyloidosis analyzed by a pathologic scoring system"],"prefix":"10.1093","volume":"160","author":[{"given":"Huijuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences, Fudan University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"L\u2019Imperio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca , Monza , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Renal Unit, University and Hospital of Verona Piazzale Stefani , Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan E","family":"Kapp","sequence":"additional","affiliation":[{"name":"Department of Pathology, Case Western Reserve University School of Medicine and University Hospitals , Cleveland, OH , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paisit","family":"Paueksakon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt 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